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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid precursor protein biosynthetic process
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Accession:GO:0042985 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms:exact_synonym: down regulation of amyloid precursor protein biosynthetic process;   downregulation of amyloid precursor protein biosynthetic process;   negative regulation of APP biosynthesis;   negative regulation of APP biosynthetic process;   negative regulation of amyloid precursor protein anabolism;   negative regulation of amyloid precursor protein biosynthesis;   negative regulation of amyloid precursor protein formation;   negative regulation of amyloid precursor protein synthesis
 narrow_synonym: inhibition of amyloid precursor protein biosynthetic process



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negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AATF apoptosis antagonizing transcription factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3028747|PMID:14627703) Ensembl
MGI
Ensembl
PMID:14627703 GO_REF:0000107 MGI:3028747 NCBI chr17:36,948,954...37,056,871
Ensembl chr17:36,948,925...37,056,871
JBrowse link
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS Alzheimers_University_of_Toronto
Alzheimers_University_of_Toronto
GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572
JBrowse link
G AGO2 argonaute RISC catalytic component 2 involved_in ISS ARUK-UCL
ARUK-UCL
GO_REF:0000024 NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633
JBrowse link
G BACE2 beta-secretase 2 involved_in IMP (PMID:12801932) UniProt
UniProt
PMID:12801932 NCBI chr21:41,168,160...41,282,530
Ensembl chr21:41,167,801...41,282,530
JBrowse link
G ITM2A integral membrane protein 2A involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G ITM2B integral membrane protein 2B involved_in IDA
IBA
(PMID:16027166), (PMID:18524908)
(PMID:21873635)
UniProt
GO_Central
GO_Central
UniProt
PMID:16027166 PMID:18524908 PMID:21873635 NCBI chr13:48,233,206...48,270,357
Ensembl chr13:48,232,612...48,270,357
JBrowse link
G ITM2C integral membrane protein 2C involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 2:230,864,185...230,879,254
Ensembl chr 2:230,864,639...230,879,248
JBrowse link
G MIR101-1 microRNA 101-1 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 1:65,058,434...65,058,508
Ensembl chr 1:65,058,434...65,058,508
JBrowse link
G MIR101-2 microRNA 101-2 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 9:4,850,297...4,850,375
Ensembl chr 9:4,850,297...4,850,375
JBrowse link
G MIR106A microRNA 106a involved_in IDA (PMID:18684319) ARUK-UCL PMID:18684319 NCBI chr  X:134,170,198...134,170,278
Ensembl chr  X:134,170,198...134,170,278
JBrowse link
G MIR144 microRNA 144 involved_in IDA (PMID:27329039) ARUK-UCL PMID:27329039 NCBI chr17:28,861,533...28,861,618
Ensembl chr17:28,861,533...28,861,618
JBrowse link
G MIR147A microRNA 147a involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr 9:120,244,979...120,245,050
Ensembl chr 9:120,244,979...120,245,050
JBrowse link
G MIR153-1 microRNA 153-1 involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr 2:219,294,111...219,294,200
Ensembl chr 2:219,294,111...219,294,200
JBrowse link
G MIR153-2 microRNA 153-2 involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr 7:157,574,336...157,574,422
Ensembl chr 7:157,574,336...157,574,422
JBrowse link
G MIR17 microRNA 17 involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr13:91,350,605...91,350,688
Ensembl chr13:91,350,605...91,350,688
JBrowse link
G MIR20A microRNA 20a involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135
JBrowse link
G MIR298 microRNA 298 involved_in IDA (PMID:31942037) ARUK-UCL PMID:31942037 NCBI chr20:58,818,226...58,818,313
Ensembl chr20:58,818,226...58,818,313
JBrowse link
G MIR31 microRNA 31 involved_in IGI (PMID:32069773) ARUK-UCL PMID:32069773 NCBI chr 9:21,512,115...21,512,185
Ensembl chr 9:21,512,115...21,512,185
JBrowse link
G MIR323A microRNA 323a involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr14:101,025,732...101,025,817
Ensembl chr14:101,025,732...101,025,817
JBrowse link
G MIR455 microRNA 455 involved_in IDA (PMID:31181293) ARUK-UCL PMID:31181293 NCBI chr 9:114,209,434...114,209,529
Ensembl chr 9:114,209,434...114,209,529
JBrowse link
G MIR520C microRNA 520c involved_in IDA (PMID:18684319) ARUK-UCL PMID:18684319 NCBI chr19:53,707,453...53,707,539
Ensembl chr19:53,707,453...53,707,539
JBrowse link
G MIR644A microRNA 644a involved_in IDA (PMID:21982160) ARUK-UCL PMID:21982160 NCBI chr20:34,466,325...34,466,418
Ensembl chr20:34,466,325...34,466,418
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19733
    metabolic process 13149
      negative regulation of metabolic process 3962
        negative regulation of cellular metabolic process 2614
          negative regulation of glycoprotein metabolic process 31
            negative regulation of glycoprotein biosynthetic process 28
              negative regulation of amyloid precursor protein biosynthetic process 22
Path 2
Term Annotations click to browse term
  biological_process 19733
    biological regulation 13881
      regulation of biological process 13143
        regulation of metabolic process 7908
          regulation of macromolecule metabolic process 7333
            regulation of macromolecule biosynthetic process 4357
              negative regulation of macromolecule biosynthetic process 1791
                negative regulation of cellular macromolecule biosynthetic process 338
                  negative regulation of glycoprotein biosynthetic process 28
                    negative regulation of amyloid precursor protein biosynthetic process 22
paths to the root