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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid precursor protein biosynthetic process
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Accession:GO:0042985 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta.
Synonyms:exact_synonym: down regulation of amyloid precursor protein biosynthetic process;   downregulation of amyloid precursor protein biosynthetic process;   negative regulation of APP biosynthesis;   negative regulation of APP biosynthetic process;   negative regulation of amyloid precursor protein anabolism;   negative regulation of amyloid precursor protein biosynthesis;   negative regulation of amyloid precursor protein formation;   negative regulation of amyloid precursor protein synthesis
 narrow_synonym: inhibition of amyloid precursor protein biosynthetic process


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negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:37,798,397...37,880,624
Ensembl chr11:37,798,370...37,880,821
JBrowse link
G Itm2a integral membrane protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IBA
ISS
(PMID:16027166), (PMID:18524908)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16027166 PMID:18524908, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:92,916,469...92,930,306
Ensembl chr 9:92,916,469...92,930,279
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    metabolic process 11878
      negative regulation of metabolic process 3198
        negative regulation of cellular metabolic process 2670
          negative regulation of glycoprotein metabolic process 18
            negative regulation of glycoprotein biosynthetic process 15
              negative regulation of amyloid precursor protein biosynthetic process 7
Path 2
Term Annotations click to browse term
  biological_process 19610
    biological regulation 13577
      regulation of biological process 12853
        regulation of metabolic process 6774
          regulation of macromolecule metabolic process 6282
            regulation of macromolecule biosynthetic process 3824
              negative regulation of macromolecule biosynthetic process 1590
                negative regulation of cellular macromolecule biosynthetic process 1574
                  negative regulation of glycoprotein biosynthetic process 15
                    negative regulation of amyloid precursor protein biosynthetic process 7
paths to the root