Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Community Projects Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid precursor protein biosynthetic process
go back to main search page
Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis


show annotations for term's descendants           Sort by:
amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:3773571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201 		JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5553242|PMID:18429932)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS		 (PMID:12801932)
GO_REF:0000024		 RGD
UniProt		 PMID:12801932 GO_REF:0000024 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Itm2a integral membrane protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363 		JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IEA
IBA
ISS		 (PMID:16027166), (PMID:18524908)
GO_REF:0000107
PMID:21873635
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16027166 PMID:18524908 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917 		JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742 		JBrowse link
G Mir106a microRNA 106a involved_in ISO (PMID:18684319) RGD PMID:18684319 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661 		JBrowse link
G Mir144 microRNA 144 involved_in ISO (PMID:27329039) RGD PMID:27329039 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir298 microRNA 298 involved_in ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir31 microRNA 31 involved_in ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir323 microRNA 323 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624 		JBrowse link
G Mir455 microRNA 455 involved_in ISO (PMID:31181293) RGD PMID:31181293 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA		 (PMID:20704561)
GO_REF:0000107		 RGD
Ensembl		 PMID:20704561 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:5569714 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA		 (PMID:17412327)
GO_REF:0000107		 RGD
Ensembl		 PMID:17412327 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 		JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      biosynthetic process 8072
        organic substance biosynthetic process 8014
          organonitrogen compound biosynthetic process 2065
            amyloid precursor protein biosynthetic process 22
              negative regulation of amyloid precursor protein biosynthetic process 16
              positive regulation of amyloid precursor protein biosynthetic process 4
              regulation of amyloid precursor protein biosynthetic process + 22
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      organic substance metabolic process 10895
        macromolecule metabolic process 9164
          protein metabolic process 4578
            amyloid precursor protein metabolic process 88
              amyloid precursor protein biosynthetic process 22
                negative regulation of amyloid precursor protein biosynthetic process 16
                positive regulation of amyloid precursor protein biosynthetic process 4
                regulation of amyloid precursor protein biosynthetic process + 22
paths to the root