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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein biosynthetic process
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Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis



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amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:3773571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Itm2a integral membrane protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363
JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IBA
ISS
(PMID:16027166), (PMID:18524908)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16027166 PMID:18524908 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742
JBrowse link
G Mir106a microRNA 106a involved_in ISO (PMID:18684319) RGD PMID:18684319 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661
JBrowse link
G Mir144 microRNA 144 involved_in ISO (PMID:27329039) RGD PMID:27329039 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681
JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Mir298 microRNA 298 involved_in ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372
JBrowse link
G Mir31 microRNA 31 involved_in ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir323 microRNA 323 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624
JBrowse link
G Mir455 microRNA 455 involved_in ISO (PMID:31181293) RGD PMID:31181293 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390
JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA
(PMID:20704561)
GO_REF:0000107
RGD
Ensembl
PMID:20704561 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Mir346 microRNA 346 involved_in ISO (PMID:30470799) RGD PMID:30470799 NCBI chr16:10,218,118...10,218,215
Ensembl chr16:10,218,118...10,218,215
JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:5569714 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA
(PMID:17412327)
GO_REF:0000107
RGD
Ensembl
PMID:17412327 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link
G Necab3 N-terminal EF-hand calcium binding protein 3 involved_in ISO (PMID:10833507) RGD PMID:10833507 NCBI chr 3:143,049,477...143,064,372
Ensembl chr 3:143,049,478...143,075,361
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      biosynthetic process 6279
        organic substance biosynthetic process 6174
          organonitrogen compound biosynthetic process 2174
            amyloid precursor protein biosynthetic process 24
              negative regulation of amyloid precursor protein biosynthetic process 16
              positive regulation of amyloid precursor protein biosynthetic process 5
              regulation of amyloid precursor protein biosynthetic process + 24
Path 2
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      nitrogen compound metabolic process 10416
        organonitrogen compound metabolic process 7133
          protein metabolic process 6102
            amyloid precursor protein metabolic process 93
              amyloid precursor protein biosynthetic process 24
                negative regulation of amyloid precursor protein biosynthetic process 16
                positive regulation of amyloid precursor protein biosynthetic process 5
                regulation of amyloid precursor protein biosynthetic process + 24
paths to the root