Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein biosynthetic process
go back to main search page
Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis


show annotations for term's descendants           Sort by:
 
amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:3773571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Itm2a integral membrane protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363
JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IBA
ISS
(PMID:16027166), (PMID:18524908)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16027166 PMID:18524908 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742
JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA
(PMID:20704561)
GO_REF:0000107
RGD
Ensembl
PMID:20704561 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:5569714 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3028747|PMID:14627703)
Ensembl
RGD
PMID:14627703 GO_REF:0000107 MGI:3028747 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA
(PMID:17412327)
GO_REF:0000107
RGD
Ensembl
PMID:17412327 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      biosynthetic process 6074
        organic substance biosynthetic process 5972
          organonitrogen compound biosynthetic process 1998
            amyloid precursor protein biosynthetic process 13
              negative regulation of amyloid precursor protein biosynthetic process 7
              positive regulation of amyloid precursor protein biosynthetic process 4
              regulation of amyloid precursor protein biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      nitrogen compound metabolic process 9983
        organonitrogen compound metabolic process 6802
          protein metabolic process 5891
            amyloid precursor protein metabolic process 73
              amyloid precursor protein biosynthetic process 13
                negative regulation of amyloid precursor protein biosynthetic process 7
                positive regulation of amyloid precursor protein biosynthetic process 4
                regulation of amyloid precursor protein biosynthetic process + 13
paths to the root