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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein biosynthetic process
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Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis


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amyloid precursor protein biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin ISO (MGI:MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:MGI:3773571 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor ISO (MGI:MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:MGI:3028747 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO
ISS
(MGI:MGI:5553242|PMID:18429932)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:18429932 GO_REF:0000024, MGI:MGI:5553242 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Ago2 argonaute RISC catalytic component 2 IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Bace2 beta-secretase 2 ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:37,798,397...37,880,624
Ensembl chr11:37,798,370...37,880,821
JBrowse link
G Itm2a integral membrane protein 2A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Itm2b integral membrane protein 2B ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:16027166), (PMID:18524908)
UniProt
RGD
PMID:16027166, PMID:18524908, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
JBrowse link
G Itm2c integral membrane protein 2C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:92,916,469...92,930,306
Ensembl chr 9:92,916,469...92,930,279
JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IEA
(PMID:20704561)
GO_REF:0000107
RGD
Ensembl
PMID:20704561 GO_REF:0000107 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Ncstn nicastrin ISO (MGI:MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:MGI:5569714 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
(MGI:MGI:3028747|PMID:14627703)
GO_REF:0000107
RGD
Ensembl
PMID:14627703 GO_REF:0000107, MGI:MGI:3028747 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO
IEA
(PMID:17412327)
GO_REF:0000107
RGD
Ensembl
PMID:17412327 GO_REF:0000107 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629
JBrowse link
G Necab3 N-terminal EF-hand calcium binding protein 3 ISO (PMID:10833507) RGD PMID:10833507 NCBI chr 3:150,047,826...150,062,806
Ensembl chr 3:150,047,826...150,073,721
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      biosynthetic process 6225
        organic substance biosynthetic process 6120
          organonitrogen compound biosynthetic process 2023
            amyloid precursor protein biosynthetic process 14
              negative regulation of amyloid precursor protein biosynthetic process 7
              positive regulation of amyloid precursor protein biosynthetic process 4
              regulation of amyloid precursor protein biosynthetic process + 14
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      nitrogen compound metabolic process 10390
        organonitrogen compound metabolic process 7186
          protein metabolic process 6264
            amyloid precursor protein metabolic process 66
              amyloid precursor protein biosynthetic process 14
                negative regulation of amyloid precursor protein biosynthetic process 7
                positive regulation of amyloid precursor protein biosynthetic process 4
                regulation of amyloid precursor protein biosynthetic process + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.