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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein metabolic process
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Accession:GO:0042982 term browser browse the term
Definition:The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP metabolic process;   APP metabolism;   amyloid precursor protein metabolism


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amyloid precursor protein metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1a aph-1 homolog A, gamma-secretase subunit ISO (PMID:25043039), (PMID:26280335) UniProtKB PMID:25043039, PMID:26280335 NCBI chrNW_004955413:506,297...509,787
Ensembl chrNW_004955413:506,297...509,787
JBrowse link
G Apoe apolipoprotein E ISO (PMID:21593558) UniProtKB PMID:21593558 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO (MGI:MGI:3699445|PMID:17301176) MGI PMID:17301176 MGI:MGI:3699445 NCBI chrNW_004955420:13,068,289...13,273,805
Ensembl chrNW_004955420:13,068,289...13,273,805
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 ISO (PMID:12805363) BHF-UCL PMID:12805363 NCBI chrNW_004955452:5,081,919...5,102,349
Ensembl chrNW_004955452:5,081,556...5,095,182
JBrowse link
G Ncstn nicastrin ISO (MGI:MGI:5293284|PMID:21597003)
(PMID:25043039), (PMID:26280335)
MGI
UniProtKB
PMID:21597003, PMID:25043039, PMID:26280335 MGI:MGI:5293284 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033
JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 ISO (MGI:MGI:4845784|PMID:21084623) UniProtKB PMID:21084623 MGI:MGI:4845784 NCBI chrNW_004955514:5,273,810...5,294,925
Ensembl chrNW_004955514:5,273,810...5,295,710
JBrowse link
G Prnp prion protein NOT ISO (MGI:MGI:4454612|PMID:20445063) ARUK-UCL PMID:20445063 MGI:MGI:4454612 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644
JBrowse link
G Psen1 presenilin 1 ISO (PMID:26280335) UniProtKB PMID:26280335 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit ISO (PMID:25043039), (PMID:26280335) UniProtKB PMID:25043039, PMID:26280335 NCBI chrNW_004955468:2,805,153...2,806,573
Ensembl chrNW_004955468:2,805,153...2,806,573
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 ISO (PMID:21593558) UniProtKB PMID:21593558 NCBI chrNW_004955406:40,985,771...41,025,929
Ensembl chrNW_004955406:40,985,478...41,025,955
JBrowse link
amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin ISO (MGI:MGI:3773571|PMID:18201567) MGI PMID:18201567 MGI:MGI:3773571 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033
JBrowse link
amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 ISO (PMID:17293612) BHF-UCL PMID:17293612 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004955450:15,853,372...15,927,966
Ensembl chrNW_004955450:15,853,366...15,928,200
JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit ISO (PMID:12297508) UniProtKB PMID:12297508 NCBI chrNW_004955413:506,297...509,787
Ensembl chrNW_004955413:506,297...509,787
JBrowse link
G Bace1 beta-secretase 1 ISO (MGI:MGI:6356260|PMID:20704561) ARUK-UCL PMID:20704561 MGI:MGI:6356260 NCBI chrNW_004955412:18,596,643...18,620,089
Ensembl chrNW_004955412:18,596,643...18,620,362
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin ISO (PMID:10924275) UniProtKB PMID:10924275 NCBI chrNW_004955493:6,696,520...6,707,849 JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO (MGI:MGI:3614236|PMID:16407971) MGI PMID:16407971 MGI:MGI:3614236 NCBI chrNW_004955464:4,533,928...4,557,893
Ensembl chrNW_004955464:4,533,928...4,558,133
JBrowse link
G Psen1 presenilin 1 ISO (MGI:MGI:1334955|PMID:10206645), (MGI:MGI:3057045|PMID:15452145)
(MGI:MGI:2150480|PMID:11567612)
MGI PMID:10206645, PMID:11567612, PMID:15452145 MGI:MGI:1334955, MGI:MGI:2150480, MGI:MGI:3057045 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISO (PMID:26260791)
(MGI:MGI:5694857|PMID:26260791)
UniProt PMID:26260791 MGI:MGI:5694857 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chrNW_004955450:15,853,372...15,927,966
Ensembl chrNW_004955450:15,853,366...15,928,200
JBrowse link
G Aph1a aph-1 homolog A, gamma-secretase subunit ISO (PMID:25043039), (PMID:26280335) UniProtKB PMID:25043039, PMID:26280335 NCBI chrNW_004955413:506,297...509,787
Ensembl chrNW_004955413:506,297...509,787
JBrowse link
G Bace1 beta-secretase 1 ISO (PMID:24352696) ARUK-UCL PMID:24352696 NCBI chrNW_004955412:18,596,643...18,620,089
Ensembl chrNW_004955412:18,596,643...18,620,362
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A ISO (PMID:25556849) ARUK-UCL PMID:25556849 NCBI chrNW_004955407:36,456,628...36,588,940
Ensembl chrNW_004955407:36,453,098...36,589,382
JBrowse link
G Ncstn nicastrin ISO (PMID:25043039), (PMID:26280335) UniProtKB PMID:25043039, PMID:26280335 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033
JBrowse link
G Psen1 presenilin 1 ISO (PMID:26280335)
(MGI:MGI:4437371|PMID:20130175)
UniProtKB
MGI
PMID:20130175, PMID:26280335 MGI:MGI:4437371 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
G Psenen presenilin enhancer, gamma-secretase subunit ISO (PMID:12660785), (PMID:25043039), (PMID:26280335) UniProt PMID:12660785, PMID:25043039, PMID:26280335 NCBI chrNW_004955468:2,805,153...2,806,573
Ensembl chrNW_004955468:2,805,153...2,806,573
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor ISO (MGI:MGI:3028747|PMID:14627703) MGI PMID:14627703 MGI:MGI:3028747 NCBI chrNW_004955451:929,278...1,033,665
Ensembl chrNW_004955451:929,510...1,033,492
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO (MGI:MGI:5553242|PMID:18429932) Alzheimers_University_of_Toronto PMID:18429932 MGI:MGI:5553242 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Ago2 argonaute RISC catalytic component 2 ISO PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861
JBrowse link
G Bace2 beta-secretase 2 ISO (PMID:12801932) UniProtKB PMID:12801932 NCBI chrNW_004955407:40,792,089...40,879,872
Ensembl chrNW_004955407:40,792,887...40,874,760
JBrowse link
G Itm2b integral membrane protein 2B ISO (PMID:16027166), (PMID:18524908) UniProtKB PMID:16027166, PMID:18524908 NCBI chrNW_004955431:1,928,706...1,935,010
Ensembl chrNW_004955431:1,928,706...1,937,238
JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 ISO (PMID:24612608) UniProtKB PMID:24612608 NCBI chrNW_004955481:4,276,847...4,298,523
Ensembl chrNW_004955481:4,276,860...4,298,523
JBrowse link
G Prnp prion protein ISO (MGI:MGI:3714552|PMID:17573534) ARUK-UCL PMID:17573534 MGI:MGI:3714552 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644
JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806, PMID:27853422 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISO (MGI:MGI:5553242|PMID:18429932)
(MGI:MGI:5487687|PMID:23467355), (MGI:MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
ARUK-UCL
PMID:18429932, PMID:23467355, PMID:27030769 MGI:MGI:5487687, MGI:MGI:5553242, MGI:MGI:5774886 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Apoe apolipoprotein E ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541, PMID:24259049 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Bin1 bridging integrator 1 ISO (PMID:27179792)
(MGI:MGI:5811968|PMID:27179792)
ARUK-UCL PMID:27179792 MGI:MGI:5811968 NCBI chrNW_004955459:3,376,149...3,423,157
Ensembl chrNW_004955459:3,399,611...3,422,621
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700
JBrowse link
G Clu clusterin ISO (PMID:12047389), (PMID:17412999) Alzheimers_University_of_Toronto PMID:12047389, PMID:17412999 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 ISO (PMID:17553422) UniProt PMID:17553422 NCBI chrNW_004955553:2,103,694...2,124,748
Ensembl chrNW_004955553:2,108,379...2,124,748
JBrowse link
G Igf1 insulin like growth factor 1 ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) MGI PMID:22992957 MGI:MGI:5444053 NCBI chrNW_004955733:6,189...30,455
Ensembl chrNW_004955733:6,189...30,455
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO (PMID:25576397)
(MGI:MGI:3620333|PMID:16554819)
UniProt PMID:16554819, PMID:25576397 MGI:MGI:3620333 NCBI chrNW_004955495:1,250,557...1,261,617
Ensembl chrNW_004955495:1,250,453...1,266,235
JBrowse link
G Prnp prion protein ISO (MGI:MGI:3714552|PMID:17573534) ARUK-UCL PMID:17573534 MGI:MGI:3714552 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644
JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806, PMID:27853422 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153), (MGI:MGI:3821635|PMID:19036982)
(PMID:16407538), (PMID:22621900)
(PMID:17855360), (PMID:21989385), (PMID:24001769), (PMID:24523320)
Alzheimers_University_of_Toronto PMID:16407538, PMID:17855360, PMID:18362153, PMID:19036982, PMID:21989385, PMID:22621900, PMID:24001769, PMID:24523320 MGI:MGI:3801250, MGI:MGI:3821635 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179
JBrowse link
G Spon1 spondin 1 ISO (MGI:MGI:3607023|PMID:16227578) MGI PMID:16227578 MGI:MGI:3607023 NCBI chrNW_004955414:29,180,246...29,475,547
Ensembl chrNW_004955414:29,179,928...29,475,547
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 ISO (PMID:27179792)
(MGI:MGI:5811968|PMID:27179792)
ARUK-UCL PMID:27179792 MGI:MGI:5811968 NCBI chrNW_004955459:3,376,149...3,423,157
Ensembl chrNW_004955459:3,399,611...3,422,621
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:16407538)
(PMID:17855360), (PMID:21989385)
Alzheimers_University_of_Toronto PMID:16407538, PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179
JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein ISO (MGI:MGI:5432454|PMID:22539346) Alzheimers_University_of_Toronto PMID:22539346 MGI:MGI:5432454 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:17855360), (PMID:21989385)
Alzheimers_University_of_Toronto PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179
JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO (PMID:20704561) ARUK-UCL PMID:20704561 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200
JBrowse link
G Ncstn nicastrin ISO (MGI:MGI:5569714|PMID:23826707) MGI PMID:23826707 MGI:MGI:5569714 NCBI chrNW_004955468:12,111,078...12,126,404
Ensembl chrNW_004955468:12,111,078...12,127,033
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO (MGI:MGI:3028747|PMID:14627703) MGI PMID:14627703 MGI:MGI:3028747 NCBI chrNW_004955405:18,434,711...18,540,710
Ensembl chrNW_004955405:18,434,711...18,540,710
JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO (PMID:17412327) BHF-UCL PMID:17412327 NCBI chrNW_004955406:18,644,351...18,708,666
Ensembl chrNW_004955406:18,655,894...18,706,891
JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO (PMID:22086926)
(PMID:20704561)
ARUK-UCL PMID:20704561, PMID:22086926 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200
JBrowse link
G Ranbp9 RAN binding protein 9 ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004955465:1,042,649...1,122,824
Ensembl chrNW_004955465:1,042,649...1,122,824
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 ISO (PMID:24305806)
(MGI:MGI:6114922|PMID:24305806)
ARUK-UCL PMID:24305806 MGI:MGI:6114922 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401
JBrowse link
G Spon1 spondin 1 ISO (MGI:MGI:3607023|PMID:16227578) MGI PMID:16227578 MGI:MGI:3607023 NCBI chrNW_004955414:29,180,246...29,475,547
Ensembl chrNW_004955414:29,179,928...29,475,547
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO PMID:22086926
(PMID:22086926)
ARUK-UCL PMID:22086926 RGD:14697726 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 ISO (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383
JBrowse link
G Apoe apolipoprotein E ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541, PMID:24259049 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G App amyloid beta precursor protein ISO (PMID:23640054) ARUK-UCL PMID:23640054 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Casp3 caspase 3 ISO (PMID:17553422) UniProt PMID:17553422 RGD:13825190 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO (MGI:MGI:4437154|PMID:20164328) ARUK-UCL PMID:20164328 MGI:MGI:4437154 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700
JBrowse link
G Clu clusterin ISO (MGI:MGI:2384259|PMID:12145324) Alzheimers_University_of_Toronto PMID:12145324 MGI:MGI:2384259 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876
JBrowse link
G Csnk1e casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chrNW_004955413:24,560,889...24,591,669 JBrowse link
G Efna1 ephrin A1 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217
Ensembl chrNW_004955545:1,610,929...1,617,460
JBrowse link
G Epha4 EPH receptor A4 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199
JBrowse link
G Gsap gamma-secretase activating protein ISO (PMID:20811458)
(MGI:MGI:4830390|PMID:20811458)
UniProtKB PMID:20811458 MGI:MGI:4830390 NCBI chrNW_004955410:7,740,548...7,810,563 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO (PMID:12761548) ARUK-UCL PMID:12761548 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:3697769|PMID:17255335)
(PMID:19808651)
ARUK-UCL PMID:17255335, PMID:19808651 MGI:MGI:3697769 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO (MGI:MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:MGI:3697769 NCBI chrNW_004955436:22,183,318...22,199,013 JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 ISO (PMID:17098871)
(MGI:MGI:3695648|PMID:17098871)
MGI PMID:17098871 MGI:MGI:3695648 NCBI chrNW_004955425:19,480,944...19,657,178
Ensembl chrNW_004955425:19,480,907...19,654,804
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO (PMID:24577224)
(MGI:MGI:5432454|PMID:22539346), (MGI:MGI:5560380|PMID:24577224)
Alzheimers_University_of_Toronto PMID:22539346, PMID:24577224 MGI:MGI:5432454, MGI:MGI:5560380 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (MGI:MGI:6414694|PMID:21329555) ARUK-UCL PMID:21329555 MGI:MGI:6414694 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 ISO (PMID:24305806)
(MGI:MGI:6114922|PMID:24305806)
ARUK-UCL PMID:24305806 MGI:MGI:6114922 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401
JBrowse link
G Slc2a13 solute carrier family 2 member 13 ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004955505:395,380...664,272
Ensembl chrNW_004955505:396,744...662,738
JBrowse link
G Sp1 Sp1 transcription factor ISO (PMID:14701757) ARUK-UCL PMID:14701757 NCBI chrNW_004955458:644,435...677,360
Ensembl chrNW_004955458:644,378...677,441
JBrowse link
G Tnf tumor necrosis factor ISO (MGI:MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:MGI:3697769 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
JBrowse link
G App amyloid beta precursor protein ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Efna1 ephrin A1 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217
Ensembl chrNW_004955545:1,610,929...1,617,460
JBrowse link
G Efna3 ephrin A3 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,570,351...1,578,610
Ensembl chrNW_004955545:1,570,339...1,577,639
JBrowse link
G Epha4 EPH receptor A4 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955454:15,025,967...15,111,142
Ensembl chrNW_004955454:15,035,979...15,111,142
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO (MGI:MGI:5432454|PMID:22539346) Alzheimers_University_of_Toronto PMID:22539346 MGI:MGI:5432454 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 ISO (MGI:MGI:6114922|PMID:24305806)
(PMID:24305806)
ARUK-UCL PMID:24305806 MGI:MGI:6114922 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab3 N-terminal EF-hand calcium binding protein 3 ISO (PMID:10833507) UniProtKB PMID:10833507 NCBI chrNW_004955422:27,644,913...27,660,538
Ensembl chrNW_004955422:27,644,916...27,659,820
JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISO (PMID:26260791) UniProt PMID:26260791 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772
JBrowse link
G Apoe apolipoprotein E ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004955596:580,106...606,210 JBrowse link
G Unc13a unc-13 homolog A ISO (MGI:MGI:5795815|PMID:23070049) ParkinsonsUK-UCL PMID:23070049 MGI:MGI:5795815 NCBI chrNW_004955524:725,353...769,745 JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) MGI PMID:22992957 MGI:MGI:5444053 NCBI chrNW_004955733:6,189...30,455
Ensembl chrNW_004955733:6,189...30,455
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT ISO (MGI:MGI:5637941|PMID:26005850) ARUK-UCL PMID:26005850 MGI:MGI:5637941 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO (PMID:16641999) UniProtKB PMID:16641999 NCBI chrNW_004955523:393,632...438,114 JBrowse link
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein ISO (PMID:24577224) Alzheimers_University_of_Toronto PMID:24577224 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      primary metabolic process 6765
        protein metabolic process 3880
          amyloid precursor protein metabolic process 60
            amyloid precursor protein biosynthetic process + 10
            amyloid precursor protein catabolic process + 49
Path 2
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      organic substance metabolic process 7321
        macromolecule metabolic process 6351
          protein metabolic process 3880
            amyloid precursor protein metabolic process 60
              amyloid precursor protein biosynthetic process + 10
              amyloid precursor protein catabolic process + 49
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.