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ONTOLOGY REPORT - ANNOTATIONS

Term:activation of Janus kinase activity
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Accession:GO:0042976 term browser browse the term
Definition:The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
Synonyms:exact_synonym: activation of JAK protein;   activation of JAK protein by tyrosine phosphorylation
 narrow_synonym: activation of JAK1 kinase activity;   activation of JAK1 protein;   activation of JAK2 kinase activity;   activation of JAK2 protein;   tyrosine phosphorylation of JAK1 protein;   tyrosine phosphorylation of JAK2 protein
 broad_synonym: positive regulation of JAK protein activity by tyrosine phosphorylation
 related_synonym: tyrosine phosphorylation of JAK protein
 alt_id: GO:0010531;   GO:0042977


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activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:9314843 RGD:6478796 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ghr growth hormone receptor IDA RGD PMID:11244571 RGD:1624962 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (MGI:63384|PMID:8378315) RGD PMID:8378315 MGI:63384 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 UniProtKB:P08575 (PMID:12574355)
PMID:21873635		 RGD PMID:12574355 PMID:21873635 RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4457458|PMID:20304997)		 UniProt
RGD		 PMID:20304997 GO_REF:0000024 MGI:4457458 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:16393965) RGD PMID:16393965 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Prl3d4 prolactin family 3, subfamily D, member 4 IMP RGD PMID:8822264 RGD:1298822 NCBI chr17:37,325,804...37,332,641
Ensembl chr17:37,325,806...37,332,667 		JBrowse link
G Prlr prolactin receptor involved_in IEA
ISO		 GO_REF:0000107
(PMID:10585417)		 Ensembl
RGD		 PMID:10585417 GO_REF:0000107 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP
ISO		 (PMID:8670418) RGD PMID:8670418 PMID:11818507 RGD:633057 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
negative regulation of activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:16254138) RGD PMID:16254138 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IDA RGD PMID:16584384 RGD:1625011 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
positive regulation of activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:15153556) RGD PMID:15153556 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Gh1 growth hormone 1 involved_in ISO (PMID:12552091) RGD PMID:12552091 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:12023369) RGD PMID:12023369 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IBA		 (PMID:12023369)
PMID:21873635		 RGD PMID:12023369 PMID:21873635 RGD:13792537 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il6r interleukin 6 receptor involved_in IBA
ISO		 PMID:21873635
(PMID:12419823)		 RGD PMID:12419823 PMID:21873635 RGD:13792537 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
regulation of activation of Janus kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2656917 (MGI:5013875|PMID:21606371)		 Ensembl
RGD		 PMID:21606371 GO_REF:0000107 MGI:5013875 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    cellular process 17330
      signal transduction 7035
        positive regulation of signal transduction 1700
          positive regulation of receptor signaling pathway via STAT 81
            positive regulation of receptor signaling pathway via JAK-STAT 76
              activation of Janus kinase activity 17
                negative regulation of activation of Janus kinase activity 2
                positive regulation of activation of Janus kinase activity 5
                regulation of activation of Janus kinase activity + 8
Path 2
Term Annotations click to browse term
  biological_process 19738
    biological regulation 13436
      regulation of biological process 13021
        regulation of metabolic process 6823
          regulation of cellular metabolic process 3143
            regulation of phosphorus metabolic process 1413
              regulation of phosphate metabolic process 1412
                regulation of phosphorylation 1252
                  regulation of protein phosphorylation 1142
                    positive regulation of protein phosphorylation 760
                      positive regulation of protein kinase activity 365
                        activation of protein kinase activity 103
                          activation of Janus kinase activity 17
                            negative regulation of activation of Janus kinase activity 2
                            positive regulation of activation of Janus kinase activity 5
                            regulation of activation of Janus kinase activity + 8
paths to the root