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ONTOLOGY REPORT - ANNOTATIONS


Term:MHC class I peptide loading complex
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Accession:GO:0042824 term browser browse the term
Definition:A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
Comment:Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
Synonyms:exact_synonym: peptide-loading complex
 related_synonym: PLC



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MHC class I peptide loading complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb9 ATP binding cassette subfamily B member 9 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:32,499,225...32,531,932
Ensembl chr12:32,499,225...32,531,931
JBrowse link
G B2m beta-2 microglobulin part_of ISO (PMID:21263072) RGD PMID:21263072 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Calr calreticulin part_of ISO (PMID:21263072)
(MGI:3813437|PMID:11825569)
RGD PMID:11825569 PMID:21263072 MGI:3813437 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 part_of IDA
IEA
ISO
PMID:17947644
GO_REF:0000107
(PMID:17947644), (PMID:21263072)
Ensembl
RGD
PMID:17947644 PMID:21263072 PMID:17947644 GO_REF:0000107, RGD:13792542 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member part_of IDA
ISO
IBA
PMID:17947644
(PMID:17947644)
PMID:21873635
RGD PMID:17947644 PMID:17947644 PMID:21873635 RGD:13792542, RGD:13792537 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member part_of IDA
IBA
ISO
PMID:21873635
(PMID:17947644)
RGD PMID:17947644 PMID:10508608 PMID:21873635 PMID:17947644 RGD:1601415, RGD:13792537, RGD:13792542 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link
G Tapbp TAP binding protein part_of IDA
ISO
(PMID:17947644), (PMID:21263072) RGD PMID:17947644 PMID:21263072 PMID:11294569 PMID:17947644 RGD:634074, RGD:13792542 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181
JBrowse link
TAP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdia3 protein disulfide isomerase family A, member 3 IDA RGD PMID:9637924 RGD:9999147 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member part_of IDA
IEA
ISO
GO_REF:0000107
(PMID:11133832), (PMID:15518576), (PMID:17947644)
Ensembl
RGD
PMID:11133832 PMID:15518576 PMID:17947644 PMID:14622282 PMID:17947644 More... GO_REF:0000107, RGD:1300480, RGD:13792542, RGD:2312377 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member part_of IDA
IEA
ISO
PMID:17947644
GO_REF:0000002
(PMID:15518576), (PMID:17947644)
InterPro
RGD
PMID:15518576 PMID:17947644 PMID:11595746 PMID:17947644 GO_REF:0000002, RGD:2312377, RGD:13792542 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19896
    protein-containing complex 5946
      endoplasmic reticulum protein-containing complex 138
        MHC class I peptide loading complex 7
          TAP complex 3
          Tapasin-ERp57 complex 0
Path 2
Term Annotations click to browse term
  cellular_component 19896
    cellular anatomical entity 19599
      organelle 13017
        intracellular organelle 12666
          intracellular membrane-bounded organelle 11161
            endoplasmic reticulum 1756
              endoplasmic reticulum subcompartment 959
                endoplasmic reticulum membrane 949
                  intrinsic component of endoplasmic reticulum membrane 151
                    integral component of endoplasmic reticulum membrane 143
                      MHC class I peptide loading complex 7
                        TAP complex 3
                        Tapasin-ERp57 complex 0
paths to the root