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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism


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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYCS cytochrome c, somatic acts_upstream_of_or_within ISO (PMID:16757556) MGI PMID:16757556 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G DUOXA1 dual oxidase maturation factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23770197) Ensembl
MGI		 PMID:23770197 GO_REF:0000107 NCBI chr 1:126,605,142...126,615,736
Ensembl chr 1:126,605,142...126,615,719 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23770197) Ensembl
MGI		 PMID:23770197 GO_REF:0000107 NCBI chr 1:126,616,631...126,620,359
Ensembl chr 1:126,613,201...126,623,388 		JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:21258655 RGD:5131481 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G NOX1 NADPH oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:82,540,664...82,575,811
Ensembl chr  X:82,540,667...82,586,532 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17766438) Ensembl
MGI		 PMID:17766438 GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15259009), (PMID:17325201) Ensembl
MGI		 PMID:15259009 PMID:17325201 GO_REF:0000107 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:16716903 RGD:1580833 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G TXN thioredoxin involved_in ISO (PMID:22492997) ParkinsonsUK-UCL PMID:22492997 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988 		JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546 		JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14980704) Ensembl
MGI		 PMID:14980704 GO_REF:0000107 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14980704) Ensembl
MGI		 PMID:14980704 GO_REF:0000107 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,572,533...126,603,084
Ensembl chr 1:126,572,492...126,603,082 		JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G GP91-PHOX NADPH oxidase heavy chain subunit acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chr  X:33,654,656...33,678,346
Ensembl chr  X:33,643,648...33,680,580 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,266...11,839,354 		JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
ISS		 (PMID:14679182) RGD
MGI
Ensembl
UniProt		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15880490 GO_REF:0000024 GO_REF:0000107 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206 		JBrowse link
G CAT catalase acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:15178682)
(PMID:642030)
(PMID:10617683), (PMID:17275685), (PMID:9600348)		 RGD
MGI
TreeGrafter
GO_Central
UniProt
Ensembl
InterPro		 PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1358492 RGD:2292202 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:126,572,533...126,603,084
Ensembl chr 1:126,572,492...126,603,082 		JBrowse link
G DUOX2 dual oxidase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G EPX eosinophil peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr12:34,486,139...34,498,879
Ensembl chr12:34,486,144...34,498,875 		JBrowse link
G GPX1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:15827346)
(PMID:10754271)
(PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:9788901)		 Ensembl
MGI
TreeGrafter
GO_Central		 PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G GPX3 glutathione peroxidase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:10617683) TreeGrafter
MGI
GO_Central		 PMID:10617683 GO_REF:0000033 GO_REF:0000118 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026 		JBrowse link
G HBB hemoglobin, beta involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:4,800,683...4,801,941
Ensembl chr 9:4,800,293...4,802,364 		JBrowse link
G HBE1 hemoglobin subunit epsilon 1 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:4,818,206...4,820,243
Ensembl chr 9:4,817,748...4,820,243 		JBrowse link
G HBM hemoglobin subunit mu involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:41,489,312...41,490,110
Ensembl chr 3:41,489,313...41,490,264 		JBrowse link
G HBQ1 hemoglobin subunit theta 1 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:41,478,282...41,480,152
Ensembl chr 3:41,478,270...41,480,119 		JBrowse link
G HBZ hemoglobin subunit zeta involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:41,490,758...41,492,883
Ensembl chr 3:41,490,328...41,492,120 		JBrowse link
G LOC100515788 hemoglobin subunit beta-like involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:4,808,580...4,809,808 JBrowse link
G LOC100621288 hemoglobin subunit epsilon-2-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:4,812,945...4,814,337 JBrowse link
G LOC100737768 hemoglobin subunit alpha-like involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:41,486,699...41,487,559 JBrowse link
G LOC110259958 hemoglobin subunit alpha involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:41,482,353...41,483,564 JBrowse link
G MPO myeloperoxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11907569)
(PMID:10085024)		 MGI
Ensembl		 PMID:10085024 PMID:11907569 GO_REF:0000107 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G PRDX1 peroxiredoxin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:11986303) MGI
TreeGrafter
GO_Central
Ensembl		 PMID:11986303 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,395...165,861,442 		JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:15902258) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:15902258 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009 		JBrowse link
G PRDX3 peroxiredoxin 3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:7733872) MGI
TreeGrafter
GO_Central
Ensembl		 PMID:7733872 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:129,079,050...129,090,790
Ensembl chr14:129,079,051...129,090,830 		JBrowse link
G PRDX4 peroxiredoxin 4 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:19,800,153...19,819,575
Ensembl chr  X:19,797,550...19,819,571 		JBrowse link
G PRDX5 peroxiredoxin 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:7,798,672...7,801,955
Ensembl chr 2:7,798,670...7,802,952 		JBrowse link
G PRDX6 peroxiredoxin 6 ISO RGD PMID:8641418 RGD:729495 NCBI chr 9:115,857,629...115,868,898
Ensembl chr 9:115,857,644...115,868,892 		JBrowse link
G PXDN peroxidasin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:132,306,288...132,362,853
Ensembl chr 3:132,306,447...132,362,841 		JBrowse link
G TPO thyroid peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:10849437 RGD:634378 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,043 		JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581 		JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:7,423,083...7,441,583
Ensembl chr 3:7,427,395...7,441,567 		JBrowse link
G PRL prolactin involved_in IMP (PMID:24530842) AgBase PMID:24530842 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HP haptoglobin involved_in ISO (PMID:19740759) BHF-UCL PMID:19740759 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G MT3 metallothionein 3 ISO RGD PMID:12058024 RGD:625483 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131 		JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11991626 RGD:10003093 NCBI chr16:25,670,832...25,686,556
Ensembl chr16:25,670,862...25,686,552 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,605,142...126,615,736
Ensembl chr 1:126,605,142...126,615,719 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,616,631...126,620,359
Ensembl chr 1:126,613,201...126,623,388 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:39,091,439...39,105,633
Ensembl chr 3:39,091,443...39,106,615 		JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NNT nicotinamide nucleotide transhydrogenase ISO RGD PMID:24722990 RGD:13513981 NCBI chr16:28,157,192...28,248,732
Ensembl chr16:28,157,318...28,250,961 		JBrowse link
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,271,128 		JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSR insulin receptor ISO in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr 2:71,797,209...71,939,923
Ensembl chr 2:71,797,204...71,936,104 		JBrowse link
G NOXA1 NADPH oxidase activator 1 involved_in IEA Ensembl GO_REF:0000107
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:78,863,195...78,884,663
Ensembl chr 6:78,863,190...78,884,640 		JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17325201) Ensembl
MGI		 PMID:17325201 GO_REF:0000107 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    cellular process 16883
      cellular metabolic process 9044
        reactive oxygen species metabolic process 257
          hydrogen peroxide metabolic process 57
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 21
            hydrogen peroxide catabolic process + 30
            negative regulation of hydrogen peroxide metabolic process + 9
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 21
paths to the root