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ONTOLOGY REPORT - ANNOTATIONS

Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism

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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO (PMID:23770197) MGI PMID:23770197 NCBI chrNW_004624731:14,109,253...14,118,106
Ensembl chrNW_004624731:14,108,924...14,118,239 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23770197) Ensembl
MGI		 PMID:23770197 GO_REF:0000107 NCBI chrNW_004624731:14,118,526...14,121,811
Ensembl chrNW_004624731:14,118,426...14,121,928 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:21258655 RGD:5131481 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G LOC101718508 cytochrome c, somatic acts_upstream_of_or_within ISO (PMID:16757556) MGI PMID:16757556 NCBI chrNW_004624739:5,411,192...5,413,995
Ensembl chrNW_004624739:5,411,273...5,413,995 		JBrowse link
G Nox1 NADPH oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624902:1,741,921...1,754,932
Ensembl chrNW_004624902:1,736,704...1,755,504 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 ISO (PMID:24567322)
(PMID:17766438)		 ParkinsonsUK-UCL
MGI		 PMID:17766438 PMID:24567322 NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (PMID:15259009), (PMID:17325201) MGI PMID:15259009 PMID:17325201 NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866 		JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:16716903 RGD:1580833 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO (PMID:18379038) ComplexPortal PMID:18379038 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739 		JBrowse link
G Txn thioredoxin involved_in ISO (PMID:22492997) ParkinsonsUK-UCL PMID:22492997 NCBI chrNW_004624758:1,318,108...1,329,011
Ensembl chrNW_004624758:1,318,529...1,329,011 		JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:14749723) UniProt PMID:14749723 NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042 		JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in ISO (PMID:32169171) FlyBase PMID:32169171 NCBI chrNW_004624801:5,844,824...5,867,439
Ensembl chrNW_004624801:5,846,729...5,867,427 		JBrowse link
G Duox1 dual oxidase 1 involved_in ISO (PMID:19339556), (PMID:22814254) UniProt PMID:19339556 PMID:22814254 NCBI chrNW_004624731:14,080,670...14,107,532
Ensembl chrNW_004624731:14,081,245...14,107,104 		JBrowse link
G Duox2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chrNW_004624731:14,121,855...14,139,344
Ensembl chrNW_004624731:14,122,608...14,138,121 		JBrowse link
G LOC101707509 cytochrome P450 1A1 acts_upstream_of_or_within ISO (PMID:14980704) MGI PMID:14980704 NCBI chrNW_004627988:7...1,323 JBrowse link
G LOC101709509 cytochrome b-245 heavy chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15258578) Ensembl
MGI		 PMID:15258578 GO_REF:0000107 NCBI chrNW_004624762:17,759,625...17,793,434
Ensembl chrNW_004624762:17,757,404...17,793,467 		JBrowse link
G LOC101717043 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chrNW_004624746:911,852...919,361
Ensembl chrNW_004624746:911,842...919,362 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chrNW_004624740:13,428,375...13,439,915
Ensembl chrNW_004624740:13,429,476...13,439,807 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:14679182)
(PMID:15544046)		 MGI
UniProt
RGD		 PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 RGD:1581090 RGD:1601266 RGD:634854 NCBI chrNW_004624745:20,032,003...20,037,958
Ensembl chrNW_004624745:20,032,011...20,037,958 		JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:12,237,329...12,240,013
Ensembl chrNW_004624784:12,233,593...12,239,763 		JBrowse link
G Cat catalase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:642030)
(PMID:10617683), (PMID:17275685), (PMID:9600348)
(PMID:15178682)		 RGD
MGI
TreeGrafter
InterPro
UniProt		 PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 RGD:1358492 RGD:2292202 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739 		JBrowse link
G Duox1 dual oxidase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624731:14,080,670...14,107,532
Ensembl chrNW_004624731:14,081,245...14,107,104 		JBrowse link
G Duox2 dual oxidase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624731:14,121,855...14,139,344
Ensembl chrNW_004624731:14,122,608...14,138,121 		JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15827346)
(PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:9788901)
(PMID:10754271)		 MGI
TreeGrafter		 PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000118 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G Gpx3 glutathione peroxidase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10617683) Ensembl
MGI
TreeGrafter		 PMID:10617683 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993 		JBrowse link
G LOC101696428 hemoglobin subunit beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624817:6,691,101...6,691,222 JBrowse link
G LOC101704581 hemoglobin subunit alpha involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,043,431...1,044,234
Ensembl chrNW_004624913:1,043,341...1,044,342 		JBrowse link
G LOC101704937 hemoglobin subunit alpha involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,036,429...1,037,330 JBrowse link
G LOC101705305 hemoglobin subunit zeta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,024,216...1,030,716
Ensembl chrNW_004624913:1,023,624...1,030,734 		JBrowse link
G LOC101718185 hemoglobin subunit gamma involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624817:6,707,524...6,709,012 JBrowse link
G LOC101718529 hemoglobin subunit epsilon-1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624817:6,713,413...6,714,951 JBrowse link
G LOC101724100 hemoglobin subunit theta-1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,045,926...1,047,093
Ensembl chrNW_004624913:1,046,227...1,047,086 		JBrowse link
G LOC110343833 hemoglobin subunit beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004625105:7,455...8,819 JBrowse link
G Mpo myeloperoxidase acts_upstream_of_or_within
involved_in		 ISO (PMID:11907569)
(PMID:10085024)
(PMID:10772654)		 MGI
BHF-UCL		 PMID:10085024 PMID:10772654 PMID:11907569 NCBI chrNW_004624871:121,026...131,433
Ensembl chrNW_004624871:121,026...131,323 		JBrowse link
G Prdx1 peroxiredoxin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11986303) MGI
TreeGrafter		 PMID:11986303 GO_REF:0000118 NCBI chrNW_004624906:1,405,253...1,414,980
Ensembl chrNW_004624906:1,405,253...1,414,926 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15902258) MGI
TreeGrafter		 PMID:15902258 GO_REF:0000118 NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866 		JBrowse link
G Prdx3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7733872) TreeGrafter
MGI		 PMID:7733872 GO_REF:0000118 NCBI chrNW_004624737:27,625,120...27,635,221 JBrowse link
G Prdx4 peroxiredoxin 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624897:92,977...112,920
Ensembl chrNW_004624897:95,521...112,920 		JBrowse link
G Prdx5 peroxiredoxin 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624767:21,995,542...21,998,609
Ensembl chrNW_004624767:21,995,681...21,997,149 		JBrowse link
G Prdx6 peroxiredoxin 6 ISO RGD PMID:8641418 RGD:729495 NCBI chrNW_004624771:8,282,622...8,293,799
Ensembl chrNW_004624771:8,282,062...8,294,340 		JBrowse link
G Pxdn peroxidasin involved_in ISO (PMID:18929642) UniProt PMID:18929642 NCBI chrNW_004624846:6,259,807...6,329,849
Ensembl chrNW_004624846:6,259,765...6,331,100 		JBrowse link
G Tpo thyroid peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624846:1,934,084...1,962,637
Ensembl chrNW_004624846:1,934,469...1,961,291 		JBrowse link
G Txnrd1 thioredoxin reductase 1 ISO RGD PMID:10849437 RGD:634378 NCBI chrNW_004624750:4,444,318...4,536,384
Ensembl chrNW_004624750:4,443,915...4,510,380 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chrNW_004624786:6,296,975...6,318,266
Ensembl chrNW_004624786:6,298,243...6,317,743 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chrNW_004624933:248,298...456,933
Ensembl chrNW_004624933:389,627...456,520 		JBrowse link
G LOC101718508 cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chrNW_004624739:5,411,192...5,413,995
Ensembl chrNW_004624739:5,411,273...5,413,995 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004624824:8,707,104...8,723,649
Ensembl chrNW_004624824:8,707,145...8,722,613 		JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:18606987) BHF-UCL PMID:18606987 NCBI chrNW_004624893:608,744...627,600
Ensembl chrNW_004624893:608,540...628,580 		JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) UniProt PMID:22814254 NCBI chrNW_004624731:14,109,253...14,118,106
Ensembl chrNW_004624731:14,108,924...14,118,239 		JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:14,118,526...14,121,811
Ensembl chrNW_004624731:14,118,426...14,121,928 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chrNW_004624818:1,041,371...1,065,061
Ensembl chrNW_004624818:1,041,369...1,065,023 		JBrowse link
G Nox4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chrNW_004624845:669,880...829,471
Ensembl chrNW_004624845:669,902...827,834 		JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004624824:837,369...852,439
Ensembl chrNW_004624824:837,373...852,710 		JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase ISO RGD PMID:24722990 RGD:13513981 NCBI chrNW_004624759:11,520,793...11,628,003
Ensembl chrNW_004624759:11,521,778...11,628,716 		JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:23507046) ParkinsonsUK-UCL PMID:23507046 NCBI chrNW_004624757:17,393,046...17,528,783
Ensembl chrNW_004624757:17,392,998...17,528,320 		JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184 		JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO (PMID:16636067) BHF-UCL PMID:16636067 NCBI chrNW_004624760:602,403...610,775
Ensembl chrNW_004624760:603,528...610,942 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:24553947) ParkinsonsUK-UCL PMID:24553947 NCBI chrNW_004624764:5,656,207...5,671,260
Ensembl chrNW_004624764:5,656,229...5,671,260 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (PMID:17325201) MGI PMID:17325201 NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17637
    cellular process 17219
      metabolic process 11013
        reactive oxygen species metabolic process 245
          hydrogen peroxide metabolic process 52
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 20
            hydrogen peroxide catabolic process + 26
            negative regulation of hydrogen peroxide metabolic process + 7
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 19
paths to the root