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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism



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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cycs cytochrome c, somatic acts_upstream_of_or_within IDA (MGI:3652666|PMID:16757556) MGI PMID:16757556 MGI:3652666 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyct cytochrome c, testis acts_upstream_of_or_within IDA (MGI:3652666|PMID:16757556) MGI PMID:16757556 MGI:3652666 NCBI chr 2:76,184,286...76,190,797
Ensembl chr 2:76,184,286...76,190,794
JBrowse link
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within IGI (MGI:5544173|PMID:23770197) MGI PMID:23770197 MGI:5544173 NCBI chr 2:122,134,012...122,144,255
Ensembl chr 2:122,132,672...122,144,211
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within IGI (MGI:5544173|PMID:23770197) MGI PMID:23770197 MGI:5544173 NCBI chr 2:122,129,381...122,133,366
Ensembl chr 2:122,129,381...122,133,366
JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:21258655 RGD:5131481 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Nox1 NADPH oxidase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 involved_in
acts_upstream_of_or_within
ISO
IMP
(MGI:3723371|PMID:17766438) MGI PMID:17766438 GO_REF:0000096 MGI:3723371 MGI:4834177 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within IMP (MGI:3050700|PMID:15259009), (MGI:3758374|PMID:17325201) MGI PMID:15259009 PMID:17325201 MGI:3050700 MGI:3758374 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial involved_in ISO RGD
MGI
PMID:16716903 GO_REF:0000096 MGI:4417868 RGD:1580833 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:116,062,709...116,089,871
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide acts_upstream_of_or_within IMP (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 acts_upstream_of_or_within IMP (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 acts_upstream_of_or_within IMP (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Duox1 dual oxidase 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,143,525...122,178,454
Ensembl chr 2:122,146,153...122,178,453
JBrowse link
G Duox2 dual oxidase 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,109,727...122,129,221
Ensembl chr 2:122,109,728...122,128,930
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within IMP (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Sod1 superoxide dismutase 1, soluble involved_in
acts_upstream_of_or_within
ISO
IMP
(MGI:2682495|PMID:14679182) MGI
RGD
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15880490 GO_REF:0000096 MGI:2682495 MGI:4417868 MGI:4834177 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial involved_in ISO RGD
MGI
PMID:15642720 GO_REF:0000096 MGI:4417868 RGD:2291946 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A-IV involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
JBrowse link
G Cat catalase involved_in
acts_upstream_of_or_within
IBA
ISO
IDA
IMP
(MGI:6201960|PMID:21873635)
(MGI:1203408|PMID:9600348), (MGI:1352605|PMID:10617683), (MGI:3698896|PMID:17275685)
(MGI:3050704|PMID:15178682)
(MGI:54448|PMID:642030)
GO_Central
MGI
RGD
PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... GO_REF:0000096 MGI:1203408 MGI:1352605 MGI:3050704 MGI:3698896 MGI:4417868 MGI:4834177 MGI:54448 MGI:6201960 RGD:1358492 RGD:2292202 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Epx eosinophil peroxidase acts_upstream_of_or_within IEA UniProt GO_REF:0000004 MGI:1354194 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362
JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within
ISO
IMP
IBA
(MGI:1314762|PMID:9788901), (MGI:3044494|PMID:15182862), (MGI:3664695|PMID:11545230), (MGI:3691391|PMID:10915565)
(MGI:3612610|PMID:15827346)
(MGI:6201960|PMID:21873635)
(MGI:1858834|PMID:10754271)
MGI
RGD
GO_Central
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000096 MGI:1314762 MGI:1858834 MGI:3044494 MGI:3612610 MGI:3664695 MGI:3691391 MGI:4417868 MGI:4834177 MGI:6201960 RGD:1624364 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx3 glutathione peroxidase 3 acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:1352605|PMID:10617683)
(MGI:6201960|PMID:21873635)
MGI
RGD
GO_Central
PMID:10617683 PMID:16140890 PMID:21873635 GO_REF:0000096 MGI:1352605 MGI:4417868 MGI:6201960 RGD:1624364 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465
JBrowse link
G Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:32,226,600...32,228,116
Ensembl chr11:32,226,400...32,228,116
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960
G Hbb-b2 hemoglobin, beta adult minor chain involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960
G Hbb-bh1 hemoglobin Z, beta-like embryonic chain involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:103,490,845...103,492,369
Ensembl chr 7:103,490,844...103,492,371
JBrowse link
G Hbb-bh2 hemoglobin beta, bh2 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:103,488,008...103,490,418
Ensembl chr 7:103,488,331...103,489,727
JBrowse link
G Hbb-bt hemoglobin, beta adult t chain involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:103,461,731...103,463,130
Ensembl chr 7:103,461,731...103,463,203
JBrowse link
G Hbb-y hemoglobin Y, beta-like embryonic chain involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:103,500,961...103,502,414
Ensembl chr 7:103,500,956...103,502,423
JBrowse link
G Hbq1a hemoglobin, theta 1A involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:32,250,069...32,250,873
Ensembl chr11:32,250,069...32,250,873
JBrowse link
G Hbq1b hemoglobin, theta 1B involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:32,236,964...32,237,912
Ensembl chr11:32,236,965...32,237,784
JBrowse link
G Mpo myeloperoxidase acts_upstream_of_or_within
involved_in
ISO
IDA
IMP
(PMID:10772654)
(MGI:1333719|PMID:10085024)
MGI
BHF-UCL
PMID:10085024 PMID:10772654 GO_REF:0000008 MGI:1333719 MGI:2154458 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000008 MGI:2154458 MGI:6201960 NCBI chr 4:116,542,796...116,557,197
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in
IMP
IBA
(MGI:3578713|PMID:15902258)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:15902258 PMID:21873635 MGI:3578713 MGI:6201960 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link
G Prdx3 peroxiredoxin 3 acts_upstream_of_or_within
involved_in
ISO (MGI:73276|PMID:7751935) MGI PMID:7751935 GO_REF:0000096 MGI:4834177 MGI:73276 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Prdx4 peroxiredoxin 4 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:154,106,914...154,125,268
Ensembl chr  X:154,106,914...154,123,750
JBrowse link
G Prdx5 peroxiredoxin 5 involved_in IBA
ISS
ISO
(MGI:6201960|PMID:21873635)
(MGI:1346358|PMID:10514471)
GO_Central
UniProt
MGI
PMID:10514471 PMID:21873635 GO_REF:0000096 MGI:1346358 MGI:4834177 MGI:6201960 NCBI chr19:6,884,065...6,887,474
Ensembl chr19:6,884,065...6,887,474
JBrowse link
G Prdx6 peroxiredoxin 6 involved_in ISO RGD
MGI
PMID:8641418 GO_REF:0000096 MGI:4417868 RGD:729495 NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789
JBrowse link
G Prdx6b peroxiredoxin 6B involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 2:80,122,814...80,125,702
Ensembl chr 2:80,122,816...80,125,700
JBrowse link
G Pxdn peroxidasin involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:29,986,641...30,067,657
Ensembl chr12:29,987,607...30,067,657
JBrowse link
G Tpo thyroid peroxidase acts_upstream_of_or_within IEA UniProt GO_REF:0000004 MGI:1354194 NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623
JBrowse link
G Txnrd1 thioredoxin reductase 1 involved_in ISO RGD
MGI
PMID:10849437 GO_REF:0000096 MGI:4417868 RGD:634378 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosis, nephropathic involved_in ISO RGD
MGI
PMID:26482480 GO_REF:0000096 MGI:4417868 RGD:12910938 NCBI chr11:73,073,959...73,089,869
Ensembl chr11:73,074,422...73,089,868
JBrowse link
G Cycs cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Fyn Fyn proto-oncogene involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
JBrowse link
G Mpv17l Mpv17 transgene, kidney disease mutant-like involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:13,721,025...13,767,483
Ensembl chr16:13,721,025...13,767,483
JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO RGD
MGI
PMID:23590160 GO_REF:0000096 MGI:4417868 RGD:8694322 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hp haptoglobin involved_in ISO (PMID:19740759) BHF-UCL PMID:19740759 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804
JBrowse link
G Mt3 metallothionein 3 involved_in ISO RGD
MGI
PMID:12058024 GO_REF:0000096 MGI:4417868 RGD:625483 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp3 matrix metallopeptidase 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) involved_in ISO RGD
MGI
PMID:11991626 GO_REF:0000096 MGI:4417868 RGD:10003093 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,134,012...122,144,255
Ensembl chr 2:122,132,672...122,144,211
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:122,129,381...122,133,366
Ensembl chr 2:122,129,381...122,133,366
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO RGD
MGI
PMID:27997345 GO_REF:0000096 MGI:4417868 RGD:12910740 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
JBrowse link
G mt-Co2 cytochrome c oxidase II, mitochondrial involved_in ISO RGD
MGI
PMID:19306371 GO_REF:0000096 MGI:4417868 RGD:13506652 NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO RGD
MGI
PMID:27279484 GO_REF:0000096 MGI:4417868 RGD:151347625 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial involved_in ISO RGD
MGI
PMID:20529999 GO_REF:0000096 MGI:4417868 RGD:27095884 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:23,788,820...23,818,729
Ensembl chr17:23,794,818...23,818,461
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase involved_in ISO RGD
MGI
PMID:24722990 GO_REF:0000096 MGI:4417868 RGD:13513981 NCBI chr13:119,472,063...119,545,793
Ensembl chr13:119,471,984...119,545,533
Ensembl chr13:119,471,984...119,545,533
JBrowse link
G Snca synuclein, alpha involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor involved_in ISO in cerebellar granule neurons RGD
MGI
PMID:17919343 GO_REF:0000096 MGI:4417868 RGD:2290474 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:24,975,679...24,985,217
Ensembl chr 2:24,975,679...24,985,161
JBrowse link
G Pink1 PTEN induced putative kinase 1 involved_in IMP (MGI:5558956|PMID:24553947) ParkinsonsUK-UCL PMID:24553947 MGI:5558956 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within IMP (MGI:3758374|PMID:17325201) MGI PMID:17325201 MGI:3758374 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28735
    cellular process 17697
      cellular metabolic process 9709
        reactive oxygen species metabolic process 267
          hydrogen peroxide metabolic process 61
            detoxification of hydrogen peroxide + 1
            hydrogen peroxide biosynthetic process + 22
            hydrogen peroxide catabolic process + 30
            negative regulation of hydrogen peroxide metabolic process + 10
            positive regulation of hydrogen peroxide metabolic process + 9
            regulation of hydrogen peroxide metabolic process + 23
paths to the root