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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism



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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYCS cytochrome c, somatic acts_upstream_of_or_within ISO (PMID:16757556) MGI PMID:16757556 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYCTP cytochrome c, testis, pseudogene acts_upstream_of_or_within ISO (PMID:16757556) MGI PMID:16757556 NCBI chr 2:178,092,500...178,104,470
Ensembl chr 2:178,092,503...178,104,470
JBrowse link
G DUOXA1 dual oxidase maturation factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23770197) Ensembl
MGI
PMID:23770197 GO_REF:0000107 NCBI chr15:45,117,366...45,129,879
Ensembl chr15:45,117,366...45,129,938
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23770197) Ensembl
MGI
PMID:23770197 GO_REF:0000107 NCBI chr15:45,114,326...45,118,421
Ensembl chr15:45,114,326...45,118,421
JBrowse link
G EGFR epidermal growth factor receptor involved_in ISO
IEA
RGD
Ensembl
PMID:21258655 GO_REF:0000107 RGD:5131481 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G NOX1 NADPH oxidase 1 involved_in IDA (PMID:11331784) BHF-UCL PMID:11331784 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within
IEA
ISO
IDA
(PMID:17766438)
(PMID:24567322)
Ensembl
MGI
ParkinsonsUK-UCL
PMID:17766438 PMID:24567322 GO_REF:0000107 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15259009), (PMID:17325201) Ensembl
MGI
PMID:15259009 PMID:17325201 GO_REF:0000107 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G SOD2 superoxide dismutase 2 involved_in ISO
IEA
RGD
Ensembl
PMID:16716903 GO_REF:0000107 RGD:1580833 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase involved_in IDA (PMID:18379038) ComplexPortal PMID:18379038 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G TXN thioredoxin involved_in IGI (PMID:22492997) ParkinsonsUK-UCL PMID:22492997 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IDA (PMID:14749723) UniProt PMID:14749723 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IMP (PMID:32169171) FlyBase PMID:32169171 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G CYBA cytochrome b-245 alpha chain involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
JBrowse link
G CYBB cytochrome b-245 beta chain involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15258578) Ensembl
MGI
PMID:15258578 GO_REF:0000107 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14980704) Ensembl
MGI
PMID:14980704 GO_REF:0000107 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14980704) Ensembl
MGI
PMID:14980704 GO_REF:0000107 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G DUOX1 dual oxidase 1 involved_in IGI
NAS
(PMID:19339556), (PMID:22814254)
(PMID:10806195)
UniProt PMID:10806195 PMID:19339556 PMID:22814254 NCBI chr15:45,129,994...45,165,574
Ensembl chr15:45,129,933...45,165,576
JBrowse link
G DUOX2 dual oxidase 2 involved_in IGI (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172
JBrowse link
G MAOB monoamine oxidase B involved_in NAS (PMID:24252804) ParkinsonsUK-UCL PMID:24252804 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IDA
ISS
(PMID:14679182)
(PMID:15544046)
RGD
MGI
Ensembl
UniProt
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 GO_REF:0000024 GO_REF:0000107 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 involved_in ISO
IEA
RGD
Ensembl
PMID:15642720 GO_REF:0000107 RGD:2291946 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 involved_in IDA (PMID:16945374) HGNC-UCL PMID:16945374 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G CAT catalase acts_upstream_of_or_within
involved_in
ISO
IBA
IDA
IEA
(PMID:10617683), (PMID:17275685), (PMID:9600348)
(PMID:642030)
(PMID:15178682)
(PMID:18379038)
RGD
MGI
GO_Central
ComplexPortal
UniProt
Ensembl
InterPro
PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 RGD:1358492 RGD:2292202 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:45,129,994...45,165,574
Ensembl chr15:45,129,933...45,165,576
JBrowse link
G DUOX2 dual oxidase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172
JBrowse link
G EPX eosinophil peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174
JBrowse link
G GPX1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
IEA
(PMID:15203190)
(PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:9788901)
(PMID:10754271)
(PMID:15827346)
BHF-UCL
MGI
GO_Central
Ensembl
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... GO_REF:0000033 GO_REF:0000107 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GPX3 glutathione peroxidase 3 involved_in
acts_upstream_of_or_within
TAS
ISO
IBA
IEA
(PMID:2491950)
(PMID:10617683)
UniProt
MGI
GO_Central
Ensembl
PMID:2491950 PMID:10617683 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G HBA1 hemoglobin subunit alpha 1 involved_in IDA
IBA
(PMID:19740759) BHF-UCL
GO_Central
PMID:19740759 GO_REF:0000033 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
JBrowse link
G HBA2 hemoglobin subunit alpha 2 involved_in IDA
IBA
(PMID:19740759) BHF-UCL
GO_Central
PMID:19740759 GO_REF:0000033 NCBI chr16:172,876...173,710
Ensembl chr16:172,876...173,710
JBrowse link
G HBB hemoglobin subunit beta involved_in IDA
IBA
(PMID:19740759) BHF-UCL
GO_Central
PMID:19740759 GO_REF:0000033 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HBD hemoglobin subunit delta involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:5,232,838...5,234,483
Ensembl chr11:5,232,678...5,243,657
JBrowse link
G HBE1 hemoglobin subunit epsilon 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:5,268,345...5,269,945
Ensembl chr11:5,268,345...5,505,652
JBrowse link
G HBG1 hemoglobin subunit gamma 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:5,248,269...5,249,857
Ensembl chr11:5,248,269...5,249,857
JBrowse link
G HBG2 hemoglobin subunit gamma 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:5,253,188...5,254,781
Ensembl chr11:5,253,188...5,505,605
JBrowse link
G HBM hemoglobin subunit mu involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:165,978...166,764
Ensembl chr16:153,892...166,764
JBrowse link
G HBQ1 hemoglobin subunit theta 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:180,459...181,179
Ensembl chr16:180,459...181,179
JBrowse link
G HBZ hemoglobin subunit zeta involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:152,644...154,503
Ensembl chr16:142,728...154,503
JBrowse link
G LPO lactoperoxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518
JBrowse link
G MPO myeloperoxidase acts_upstream_of_or_within
involved_in
IDA
IEA
(PMID:11907569)
(PMID:10772654)
MGI
Ensembl
UniProt
BHF-UCL
PMID:10772654 PMID:11907569 GO_REF:0000043 GO_REF:0000107 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G PRDX1 peroxiredoxin 1 acts_upstream_of_or_within
involved_in
IDA
IBA
(PMID:11986303)
(PMID:18606987)
MGI
GO_Central
BHF-UCL
PMID:11986303 PMID:18606987 GO_REF:0000033 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
TAS
ISO
IBA
IEA
(PMID:18606987)
(PMID:15902258)
BHF-UCL
MGI
GO_Central
Ensembl
PMID:15902258 PMID:18606987 GO_REF:0000033 GO_REF:0000107 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G PRDX3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within
IMP
IBA
IDA
(PMID:18195003)
(PMID:7733872)
UniProt
GO_Central
MGI
PMID:7733872 PMID:18195003 GO_REF:0000033 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRDX4 peroxiredoxin 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:23,667,493...23,686,397
Ensembl chr  X:23,664,262...23,686,397
JBrowse link
G PRDX5 peroxiredoxin 5 involved_in IDA
IBA
(PMID:10514471) UniProt
GO_Central
PMID:10514471 GO_REF:0000033 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
JBrowse link
G PRDX6 peroxiredoxin 6 ISO RGD PMID:8641418 RGD:729495 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PXDN peroxidasin involved_in IDA
IEA
(PMID:18929642) UniProt PMID:18929642 GO_REF:0000043 NCBI chr 2:1,631,887...1,744,901
Ensembl chr 2:1,631,887...1,744,852
JBrowse link
G PXDNL peroxidasin like involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:51,319,577...51,809,445
Ensembl chr 8:51,319,577...51,809,445
JBrowse link
G TPO thyroid peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:10849437 RGD:634378 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in ISO
IEA
RGD
Ensembl
PMID:26482480 GO_REF:0000107 RGD:12910938 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103
JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISS (PMID:27525436) ARUK-UCL PMID:27525436 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IDA (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr16:15,395,754...15,413,271
Ensembl chr16:15,395,754...15,413,271
JBrowse link
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HP haptoglobin involved_in IDA (PMID:19740759) BHF-UCL PMID:19740759 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055
JBrowse link
G MT3 metallothionein 3 involved_in ISO
IEA
RGD
Ensembl
PMID:12058024 GO_REF:0000107 RGD:625483 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IMP (PMID:18606987) BHF-UCL PMID:18606987 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in IMP (PMID:22814254) UniProt PMID:22814254 NCBI chr15:45,117,366...45,129,879
Ensembl chr15:45,117,366...45,129,938
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in IDA
IMP
(PMID:16651268)
(PMID:22814254)
UniProt PMID:16651268 PMID:22814254 NCBI chr15:45,114,326...45,118,421
Ensembl chr15:45,114,326...45,118,421
JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G SOD2 superoxide dismutase 2 involved_in ISO
IEA
RGD
Ensembl
PMID:20529999 GO_REF:0000107 RGD:27095884 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G ZNF205 zinc finger protein 205 involved_in IMP (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr16:3,112,586...3,120,517
Ensembl chr16:3,112,560...3,120,517
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NNT nicotinamide nucleotide transhydrogenase involved_in ISO
IEA
RGD
Ensembl
PMID:24722990 GO_REF:0000107 RGD:13513981 NCBI chr 5:43,602,675...43,707,396
Ensembl chr 5:43,602,692...43,707,405
JBrowse link
G SNCA synuclein alpha involved_in IDA (PMID:23507046) ParkinsonsUK-UCL PMID:23507046 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSR insulin receptor ISO in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G NOXA1 NADPH oxidase activator 1 involved_in IMP (PMID:16636067) BHF-UCL PMID:16636067 NCBI chr 9:137,423,393...137,434,406
Ensembl chr 9:137,423,350...137,434,406
JBrowse link
G NOXO1 NADPH oxidase organizer 1 involved_in TAS (PMID:16636067) BHF-UCL PMID:16636067 NCBI chr16:1,978,917...1,981,469
Ensembl chr16:1,978,917...1,984,192
JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17325201) Ensembl
MGI
PMID:17325201 GO_REF:0000107 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G RAC1 Rac family small GTPase 1 involved_in TAS (PMID:16636067) BHF-UCL PMID:16636067 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
JBrowse link
G RAC2 Rac family small GTPase 2 involved_in TAS (PMID:16636067) BHF-UCL PMID:16636067 NCBI chr22:37,225,270...37,244,269
Ensembl chr22:37,225,270...37,259,594
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20482
    cellular process 19724
      metabolic process 13551
        reactive oxygen species metabolic process 293
          hydrogen peroxide metabolic process 65
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 22
            hydrogen peroxide catabolic process + 33
            negative regulation of hydrogen peroxide metabolic process + 9
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 24
paths to the root