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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism


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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23770197) Ensembl
MGI
PMID:23770197 GO_REF:0000107 NCBI chr26:38,074,870...38,084,943
Ensembl chr26:38,074,775...38,086,340
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23770197) Ensembl
MGI
PMID:23770197 GO_REF:0000107 NCBI chr26:38,084,943...38,089,701
Ensembl chr26:38,086,092...38,089,420
JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:21258655 RGD:5131481 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239
JBrowse link
G LOC103226354 cytochrome c acts_upstream_of_or_within ISO (PMID:16757556) MGI PMID:16757556 NCBI chr21:33,251,825...33,253,298 JBrowse link
G NOX1 NADPH oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:89,182,636...89,210,176
Ensembl chr  X:89,183,264...89,209,298
JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17766438) Ensembl
MGI
PMID:17766438 GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434
JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15259009), (PMID:17325201) MGI
Ensembl
PMID:15259009 PMID:17325201 GO_REF:0000107 NCBI chr 6:11,484,452...11,489,067
Ensembl chr 6:11,481,784...11,489,051
JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:16716903 RGD:1580833 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
JBrowse link
G TXN thioredoxin involved_in ISO (PMID:22492997) ParkinsonsUK-UCL PMID:22492997 NCBI chr12:29,296,166...29,308,979 JBrowse link
detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:45,706,009...45,745,564
Ensembl chr16:45,706,360...45,740,247
JBrowse link
G CYBB cytochrome b-245 heavy chain acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14980704) Ensembl
MGI
PMID:14980704 GO_REF:0000107 NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 acts_upstream_of_or_within ISO (PMID:14980704) MGI PMID:14980704 NCBI chr26:8,727,996...8,733,254 JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:38,038,093...38,073,993
Ensembl chr26:38,038,771...38,072,023
JBrowse link
G DUOX2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chr26:38,090,053...38,110,781
Ensembl chr26:38,090,648...38,109,636
JBrowse link
G LOC103233451 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750
JBrowse link
G NCF1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (PMID:15258578) MGI PMID:15258578 NCBI chr28:8,334,172...8,349,828
Ensembl chr28:8,332,772...8,349,804
JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
ISO (PMID:14679182)
(PMID:15544046)
RGD
MGI
UniProt
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 RGD:1581090 RGD:1601266 RGD:634854 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA4 apolipoprotein A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698
JBrowse link
G CAT catalase involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:10617683), (PMID:17275685), (PMID:9600348)
(PMID:15178682)
(PMID:642030)
RGD
InterPro
UniProt
MGI
TreeGrafter
Ensembl
PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1358492 RGD:2292202 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr26:38,038,093...38,073,993
Ensembl chr26:38,038,771...38,072,023
JBrowse link
G DUOX2 dual oxidase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr26:38,090,053...38,110,781
Ensembl chr26:38,090,648...38,109,636
JBrowse link
G GPX1 glutathione peroxidase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:15203190)
(PMID:10754271)
(PMID:10915565), (PMID:11545230), (PMID:15182862), (PMID:9788901)
(PMID:15827346)
BHF-UCL
MGI
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... NCBI chr22:10,754,976...10,756,617 JBrowse link
G GPX1 glutathione peroxidase 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 Ensembl chr22:10,754,970...10,757,057 JBrowse link
G GPX3 glutathione peroxidase 3 acts_upstream_of_or_within ISO (PMID:10617683) MGI PMID:10617683 NCBI chr23:53,576,950...53,585,321 JBrowse link
G HBA hemoglobin subunit alpha involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:125,078...125,981 JBrowse link
G HBB hemoglobin subunit beta involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 1:61,494,327...61,496,015
Ensembl chr 1:61,494,400...61,496,073
JBrowse link
G HBD hemoglobin subunit delta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:61,487,042...61,488,628
Ensembl chr 1:61,487,042...61,488,505
JBrowse link
G HBE1 hemoglobin subunit epsilon 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:61,450,297...61,453,203
Ensembl chr 1:61,451,654...61,453,074
JBrowse link
G HBG hemoglobin subunit gamma involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:61,471,625...61,473,226 JBrowse link
G HBM hemoglobin subunit mu involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:110,077...110,876
Ensembl chr 5:110,114...110,822
JBrowse link
G HBQ1 hemoglobin subunit theta 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:133,766...134,752
Ensembl chr 5:134,059...134,681
JBrowse link
G LOC119623545 hemoglobin subunit zeta involved_in IEA TreeGrafter GO_REF:0000118
G LOC119623710 hemoglobin subunit gamma-1 involved_in IEA TreeGrafter GO_REF:0000118
G MPO myeloperoxidase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11907569)
(PMID:10085024)
MGI
Ensembl
PMID:10085024 PMID:11907569 GO_REF:0000107 NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671
JBrowse link
G PRDX1 peroxiredoxin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11986303) MGI
Ensembl
TreeGrafter
PMID:11986303 GO_REF:0000107 GO_REF:0000118 NCBI chr20:87,267,026...87,277,634
Ensembl chr20:87,267,044...87,279,978
JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15902258) MGI
Ensembl
TreeGrafter
PMID:15902258 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:11,484,452...11,489,067
Ensembl chr 6:11,481,784...11,489,051
JBrowse link
G PRDX3 peroxiredoxin 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:7733872) MGI
TreeGrafter
Ensembl
PMID:7733872 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:111,957,865...111,968,514
Ensembl chr 9:111,955,952...111,968,475
JBrowse link
G PRDX4 peroxiredoxin 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:22,113,405...22,136,307
Ensembl chr  X:22,116,605...22,136,308
JBrowse link
G PRDX5 peroxiredoxin 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:9,912,947...9,917,439
Ensembl chr 1:9,912,898...9,917,361
JBrowse link
G PRDX6 peroxiredoxin 6 ISO RGD PMID:8641418 RGD:729495 NCBI chr25:55,706,920...55,719,196
Ensembl chr25:55,706,885...55,718,665
JBrowse link
G PXDN peroxidasin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:105,936,992...106,060,582
Ensembl chr14:105,937,198...106,060,584
JBrowse link
G TPO thyroid peroxidase involved_in IEA UniProt GO_REF:0000043 NCBI chr14:106,148,214...106,255,442
Ensembl chr14:106,146,946...106,255,298
JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO RGD PMID:10849437 RGD:634378 NCBI chr11:99,375,740...99,559,929
Ensembl chr11:99,490,597...99,560,267
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr13:61,988,265...62,218,756
Ensembl chr13:62,159,874...62,219,672
JBrowse link
G LOC103226354 cytochrome c ISO RGD PMID:21410437 RGD:7349317 NCBI chr21:33,251,825...33,253,298 JBrowse link
G LOC103242158 cystinosin ISO RGD PMID:26482480 RGD:12910938 NCBI chr16:3,138,716...3,164,512
Ensembl chr16:3,138,734...3,164,625
JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr 5:14,397,299...14,407,694 JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:14,397,543...14,408,144 JBrowse link
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr17:49,922,750...49,938,084
Ensembl chr17:49,928,321...49,938,631
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984
JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MT3 metallothionein 3 ISO RGD PMID:12058024 RGD:625483 NCBI chr 5:42,502,306...42,504,467 JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in ISO (PMID:18606987) BHF-UCL PMID:18606987 NCBI chr  X:45,927,625...45,951,636
Ensembl chr  X:45,928,092...45,952,929
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:38,074,870...38,084,943
Ensembl chr26:38,074,775...38,086,340
JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:38,084,943...38,089,701
Ensembl chr26:38,086,092...38,089,420
JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chr20:119,787,700...119,818,455
Ensembl chr20:119,787,370...119,816,693
JBrowse link
G NOX4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chr 1:80,470,418...80,642,513
Ensembl chr 1:80,470,826...80,642,722
JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:2,827,888...2,844,569
Ensembl chr 5:2,837,617...2,844,383
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NNT nicotinamide nucleotide transhydrogenase ISO RGD PMID:24722990 RGD:13513981 NCBI chr 4:42,377,979...42,476,247
Ensembl chr 4:42,384,435...42,477,002
JBrowse link
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,083,154...38,194,068
Ensembl chr 7:38,081,509...38,191,479
JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSR insulin receptor ISO in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592
JBrowse link
G NOXA1 NADPH oxidase activator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:758,107...769,252
Ensembl chr12:758,152...769,095
JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:111,902,135...111,919,082
Ensembl chr20:111,902,765...111,919,069
JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17325201) MGI
Ensembl
PMID:17325201 GO_REF:0000107 NCBI chr 6:11,484,452...11,489,067
Ensembl chr 6:11,481,784...11,489,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19801
    cellular process 19323
      metabolic process 13113
        reactive oxygen species metabolic process 271
          hydrogen peroxide metabolic process 57
            detoxification of hydrogen peroxide + 3
            hydrogen peroxide biosynthetic process + 22
            hydrogen peroxide catabolic process + 29
            negative regulation of hydrogen peroxide metabolic process + 9
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 21
paths to the root