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ONTOLOGY REPORT - ANNOTATIONS


Term:hydrogen peroxide metabolic process
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Accession:GO:0042743 term browser browse the term
Definition:The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
Synonyms:exact_synonym: H2O2 metabolic process;   hydrogen peroxide metabolism


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hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO (MGI:5544173|PMID:23770197) MGI PMID:23770197 MGI:5544173 NCBI chrNW_004955409:8,256,707...8,266,891
Ensembl chrNW_004955409:8,256,707...8,266,891
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 acts_upstream_of_or_within ISO (MGI:5544173|PMID:23770197) MGI PMID:23770197 MGI:5544173 NCBI chrNW_004955409:8,266,873...8,270,486
Ensembl chrNW_004955409:8,266,873...8,270,486
JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:21258655 RGD:5131481 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G LOC102023786 cytochrome c, somatic acts_upstream_of_or_within ISO (MGI:3652666|PMID:16757556) MGI PMID:16757556 MGI:3652666 NCBI chrNW_004955410:27,086,405...27,089,255
Ensembl chrNW_004955410:27,086,405...27,089,255
JBrowse link
G Nox1 NADPH oxidase 1 involved_in ISO (PMID:11331784) BHF-UCL PMID:11331784 NCBI chrNW_004955503:6,973,965...7,020,182
Ensembl chrNW_004955503:6,974,239...6,997,618
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within
ISO (PMID:20969476), (PMID:24567322)
(MGI:3723371|PMID:17766438)
ParkinsonsUK-UCL
MGI
PMID:17766438 PMID:20969476 PMID:24567322 MGI:3723371 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (MGI:3050700|PMID:15259009), (MGI:3758374|PMID:17325201) MGI PMID:15259009 PMID:17325201 MGI:3050700 MGI:3758374 NCBI chrNW_004955415:31,880,801...31,884,453
Ensembl chrNW_004955415:31,880,588...31,884,778
JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:16716903 RGD:1580833 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
cellular detoxification of hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase involved_in ISO (PMID:18379038) ComplexPortal PMID:18379038 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
JBrowse link
hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in ISO (PMID:32169171) FlyBase PMID:32169171 NCBI chrNW_004955506:6,286,824...6,309,764
Ensembl chrNW_004955506:6,286,648...6,312,716
JBrowse link
G Duox1 dual oxidase 1 involved_in ISO (PMID:19339556), (PMID:22814254) UniProt PMID:19339556 PMID:22814254 NCBI chrNW_004955409:8,228,754...8,256,575
Ensembl chrNW_004955409:8,229,199...8,255,003
JBrowse link
G Duox2 dual oxidase 2 involved_in ISO (PMID:16651268), (PMID:19339556), (PMID:22814254), (PMID:25761904) UniProt PMID:16651268 PMID:19339556 PMID:22814254 PMID:25761904 NCBI chrNW_004955409:8,270,657...8,288,201
Ensembl chrNW_004955409:8,271,164...8,287,096
JBrowse link
G LOC102004641 cytochrome b-245 light chain involved_in ISO PMID:8798532 BHF-UCL PMID:8798532 RGD:2317869 NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118
JBrowse link
G LOC102010322 cytochrome P450 1A2 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chrNW_004955450:3,165,107...3,171,894
Ensembl chrNW_004955450:3,165,106...3,171,942
JBrowse link
G LOC102010850 cytochrome P450 1A1 acts_upstream_of_or_within ISO (MGI:3037497|PMID:14980704) MGI PMID:14980704 MGI:3037497 NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
JBrowse link
G LOC102012042 cytochrome b-245 heavy chain acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chrNW_004955587:781,533...818,149
Ensembl chrNW_004955587:781,388...819,912
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within ISO (MGI:3050718|PMID:15258578) MGI PMID:15258578 MGI:3050718 NCBI chrNW_004955456:13,353,780...13,363,956
Ensembl chrNW_004955456:13,354,011...13,363,891
JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within
involved_in
ISO (MGI:2682495|PMID:14679182)
(PMID:15544046)
RGD
MGI
UniProt
PMID:10640619 PMID:12514262 PMID:14679182 PMID:15544046 PMID:15880490 MGI:2682495 RGD:1581090 RGD:1601266 RGD:634854 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:15642720 RGD:2291946 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 involved_in ISO (PMID:16945374) HGNC-UCL PMID:16945374 NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
JBrowse link
G Cat catalase acts_upstream_of_or_within
involved_in
ISO (MGI:54448|PMID:642030)
(MGI:1203408|PMID:9600348), (MGI:1352605|PMID:10617683), (MGI:3698896|PMID:17275685)
(MGI:3050704|PMID:15178682)
(PMID:18379038)
RGD
MGI
UniProt
PMID:642030 PMID:9600348 PMID:10617683 PMID:14713308 PMID:15178682 More... MGI:1203408 MGI:1352605 MGI:3050704 MGI:3698896 MGI:54448 RGD:1358492 RGD:2292202 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within
involved_in
ISO (MGI:1314762|PMID:9788901), (MGI:3044494|PMID:15182862), (MGI:3664695|PMID:11545230), (MGI:3691391|PMID:10915565)
(MGI:1858834|PMID:10754271)
(MGI:3612610|PMID:15827346)
(PMID:15203190)
RGD
MGI
BHF-UCL
PMID:9788901 PMID:10754271 PMID:10915565 PMID:11545230 PMID:15182862 More... MGI:1314762 MGI:1858834 MGI:3044494 MGI:3612610 MGI:3664695 MGI:3691391 RGD:1624364 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G Gpx3 glutathione peroxidase 3 acts_upstream_of_or_within ISO (MGI:1352605|PMID:10617683) RGD
MGI
PMID:10617683 PMID:16140890 MGI:1352605 RGD:1624364 NCBI chrNW_004955408:2,622,162...2,629,088
Ensembl chrNW_004955408:2,622,741...2,629,032
JBrowse link
G Hbb hemoglobin subunit beta involved_in ISO (PMID:19740759) BHF-UCL PMID:19740759 NCBI chrNW_004955414:21,188,012...21,189,363 JBrowse link
G Mpo myeloperoxidase acts_upstream_of_or_within
involved_in
ISO (MGI:1333719|PMID:10085024)
(PMID:11907569)
(PMID:10772654)
MGI
BHF-UCL
PMID:10085024 PMID:10772654 PMID:11907569 MGI:1333719 NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
JBrowse link
G Prdx1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:18606987)
(PMID:11986303)
BHF-UCL
MGI
PMID:11986303 PMID:18606987 NCBI chrNW_004955464:12,761,390...12,773,413
Ensembl chrNW_004955464:12,761,401...12,773,146
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (MGI:3578713|PMID:15902258) MGI PMID:15902258 MGI:3578713 NCBI chrNW_004955415:31,880,801...31,884,453
Ensembl chrNW_004955415:31,880,588...31,884,778
JBrowse link
G Prdx3 peroxiredoxin 3 involved_in
acts_upstream_of_or_within
ISO (PMID:18195003)
(PMID:7733872)
UniProt
MGI
PMID:7733872 PMID:18195003 NCBI chrNW_004955431:23,640,775...23,651,738
Ensembl chrNW_004955431:23,638,765...23,652,191
JBrowse link
G Prdx5 peroxiredoxin 5 involved_in ISO (PMID:10514471) UniProt PMID:10514471 NCBI chrNW_004955422:20,763,822...20,766,976
Ensembl chrNW_004955422:20,761,495...20,766,976
JBrowse link
G Prdx6 peroxiredoxin 6 ISO RGD PMID:8641418 RGD:729495 NCBI chrNW_004955406:13,717,267...13,728,216
Ensembl chrNW_004955406:13,717,267...13,728,216
JBrowse link
G Pxdn peroxidasin involved_in ISO (PMID:18929642) UniProt PMID:18929642 NCBI chrNW_004955487:4,867,427...4,936,454
Ensembl chrNW_004955487:4,867,427...4,936,522
JBrowse link
G Txnrd1 thioredoxin reductase 1 ISO RGD PMID:10849437 RGD:634378 NCBI chrNW_004955405:38,863,762...38,928,615
Ensembl chrNW_004955405:38,903,918...38,927,410
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter ISO RGD PMID:26482480 RGD:12910938 NCBI chrNW_004955467:13,151,663...13,169,005
Ensembl chrNW_004955467:13,151,957...13,168,696
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in ISO PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chrNW_004955411:36,403,156...36,597,660
Ensembl chrNW_004955411:36,401,842...36,512,054
JBrowse link
G LOC102023786 cytochrome c, somatic ISO RGD PMID:21410437 RGD:7349317 NCBI chrNW_004955410:27,086,405...27,089,255
Ensembl chrNW_004955410:27,086,405...27,089,255
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:269,382...313,056 JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004955483:4,495,257...4,503,377 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687
JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:11991626 RGD:10003093 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) UniProt PMID:22814254 NCBI chrNW_004955409:8,256,707...8,266,891
Ensembl chrNW_004955409:8,256,707...8,266,891
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268)
(PMID:22814254)
UniProt PMID:16651268 PMID:22814254 NCBI chrNW_004955409:8,266,873...8,270,486
Ensembl chrNW_004955409:8,266,873...8,270,486
JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:27997345 RGD:12910740 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772
JBrowse link
G Nox4 NADPH oxidase 4 ISO RGD PMID:27279484 RGD:151347625 NCBI chrNW_004955414:4,062,337...4,220,032
Ensembl chrNW_004955414:4,062,081...4,212,746
JBrowse link
G Sod2 superoxide dismutase 2 ISO RGD PMID:20529999 RGD:27095884 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:14,242,239...14,249,276
Ensembl chrNW_004955442:14,242,423...14,249,309
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase ISO RGD PMID:24722990 RGD:13513981 NCBI chrNW_004955446:18,685,511...18,778,024
Ensembl chrNW_004955446:18,685,516...18,778,024
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:23507046) ParkinsonsUK-UCL PMID:23507046 NCBI chrNW_004955405:854,011...962,741
Ensembl chrNW_004955405:853,946...965,403
JBrowse link
regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO in cerebellar granule neurons RGD PMID:17919343 RGD:2290474 NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149
JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in ISO (PMID:16636067) BHF-UCL PMID:16636067 NCBI chrNW_004955513:5,345,521...5,352,879
Ensembl chrNW_004955513:5,345,619...5,352,834
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) ParkinsonsUK-UCL PMID:24553947 MGI:5558956 NCBI chrNW_004955452:1,171,115...1,186,338
Ensembl chrNW_004955452:1,171,205...1,185,125
JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (MGI:3758374|PMID:17325201) MGI PMID:17325201 MGI:3758374 NCBI chrNW_004955415:31,880,801...31,884,453
Ensembl chrNW_004955415:31,880,588...31,884,778
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12199
    cellular process 11340
      cellular metabolic process 6670
        reactive oxygen species metabolic process 214
          hydrogen peroxide metabolic process 43
            detoxification of hydrogen peroxide + 1
            hydrogen peroxide biosynthetic process + 21
            hydrogen peroxide catabolic process + 15
            negative regulation of hydrogen peroxide metabolic process + 7
            positive regulation of hydrogen peroxide metabolic process + 8
            regulation of hydrogen peroxide metabolic process + 19
paths to the root