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ONTOLOGY REPORT - ANNOTATIONS

Term:fear response
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Accession:GO:0042596 term browser browse the term
Definition:The response of an organism to a perceived external threat.
Synonyms:exact_synonym: physiological fear response
 alt_id: GO:0001663


show annotations for term's descendants           Sort by:
fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A acts_upstream_of_or_within ISO (PMID:15105370) RGD PMID:15105370 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15066288)		 Ensembl
RGD		 PMID:15066288 GO_REF:0000107 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO MGI:6729893 (PMID:21731499) RGD PMID:21731499 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO MGI:4356167 (PMID:26463346), (PMID:26501181) RGD PMID:26463346 PMID:26501181 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Bdnf brain-derived neurotrophic factor acts_upstream_of_or_within ISO MGI:2176750 (PMID:15249684) RGD PMID:15249684 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO MGI:2179732 (PMID:10801976) RGD PMID:10801976 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:22192380), (PMID:24509724) RGD PMID:22192380 PMID:24509724 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO
IEA		 (MGI:1267130|PMID:9655498)
GO_REF:0000107		 RGD
Ensembl		 PMID:9655498 GO_REF:0000107 MGI:1267130 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857556 (PMID:15066288)		 Ensembl
RGD		 PMID:15066288 GO_REF:0000107 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Drd4 dopamine receptor D4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2178631 (PMID:11860516)		 Ensembl
RGD		 PMID:11860516 GO_REF:0000107 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (PMID:22411800) RGD PMID:22411800 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B acts_upstream_of_or_within ISO (PMID:16157280) RGD PMID:16157280 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:17641738 RGD:2325286 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3522476 (PMID:16107644)		 Ensembl
RGD		 PMID:16107644 GO_REF:0000107 NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737 		JBrowse link
G Ankfn1 ankyrin-repeat and fibronectin type III domain containing 1 acts_upstream_of_or_within ISO MGI:2183465 (PMID:26131556) RGD PMID:26131556 NCBI chr10:74,214,143...74,602,825
Ensembl chr10:74,218,915...74,663,295 		JBrowse link
G Asic1 acid sensing ion channel subunit 1 acts_upstream_of_or_within ISO (PMID:25828470) RGD PMID:25828470 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25828470)		 Ensembl
RGD		 PMID:25828470 GO_REF:0000107 NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO (MGI:2664023|PMID:12805306) RGD PMID:12805306 MGI:2664023 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857430 (PMID:16095731)		 Ensembl
RGD		 PMID:16095731 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor acts_upstream_of_or_within ISO MGI:2176750 (PMID:15249684) RGD PMID:15249684 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Brinp1 BMP/retinoic acid inducible neural specific 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5698819 (PMID:24528488)		 Ensembl
RGD		 PMID:24528488 GO_REF:0000107 NCBI chr 5:82,348,501...82,550,506
Ensembl chr 5:82,348,930...82,493,150 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO MGI:2451031 (PMID:11854466) RGD PMID:11854466 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO (PMID:31164811) RGD PMID:31164811 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Dbi diazepam binding inhibitor acts_upstream_of_or_within ISO (PMID:17150371) RGD PMID:17150371 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Deaf1 DEAF1 transcription factor involved_in ISO (MGI:5576037|PMID:24726472) RGD PMID:24726472 MGI:5576037 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 acts_upstream_of_or_within ISO MGI:2150161 (PMID:16712972) RGD PMID:16712972 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857158 (PMID:11172752)		 Ensembl
RGD		 PMID:11172752 GO_REF:0000107 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd4 dopamine receptor D4 IMP RGD PMID:16708027 RGD:1600974 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E acts_upstream_of_or_within ISO MGI:1270849|MGI:2384784 (PMID:24990923) RGD PMID:24990923 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 acts_upstream_of_or_within ISO MGI:1270849|MGI:95305 (PMID:24990923) RGD PMID:24990923 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:15514081 RGD:1582265 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fbxl20 F-box and leucine-rich repeat protein 20 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3765911 (PMID:21390313)		 Ensembl
RGD		 PMID:21390313 GO_REF:0000107 NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 acts_upstream_of_or_within ISO MGI:2183170 (PMID:12084936) RGD PMID:12084936 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917 		JBrowse link
G Gng7 G protein subunit gamma 7 acts_upstream_of_or_within ISO MGI:2451322 (PMID:12488442) RGD PMID:12488442 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 acts_upstream_of_or_within ISO MGI:1857979 (PMID:15673679) RGD PMID:15673679 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B acts_upstream_of_or_within IMP
ISO		 MGI:3701351 (PMID:16710293) RGD PMID:16710293 PMID:21285873 RGD:13210750 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grm7 glutamate metabotropic receptor 7 NOT|involved_in
acts_upstream_of_or_within		 ISO (PMID:17167337)
MGI:1857984 (PMID:9920659)		 RGD PMID:9920659 PMID:17167337 NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344 		JBrowse link
G Hcrt hypocretin neuropeptide precursor NAS RGD PMID:14614918 RGD:1358373 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A involved_in ISS
ISO		 GO_REF:0000024
(MGI:1314969|PMID:9826725)		 UniProt
RGD		 PMID:9826725 GO_REF:0000024 MGI:1314969 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:3798744|PMID:17451451)		 UniProt
RGD		 PMID:17451451 GO_REF:0000024 MGI:3798744 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 acts_upstream_of_or_within ISO (PMID:29915039) RGD PMID:29915039 NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930 		JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 acts_upstream_of_or_within ISO MGI:3840549 (PMID:19246390) RGD PMID:19246390 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 involved_in ISO (MGI:4849330|PMID:21048139) RGD PMID:21048139 MGI:4849330 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982 		JBrowse link
G Mdk midkine involved_in ISO
IEA		 (MGI:2178952|PMID:10096022)
GO_REF:0000107		 RGD
Ensembl		 PMID:10096022 GO_REF:0000107 MGI:2178952 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mecp2 methyl CpG binding protein 2 acts_upstream_of_or_within ISO MGI:2158353|MGI:2176754|MGI:3800596 (PMID:16199017), (PMID:16467389) RGD PMID:16199017 PMID:16467389 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Morc1 MORC family CW-type zinc finger 1 acts_upstream_of_or_within ISO MGI:1857787 (PMID:26275923) RGD PMID:26275923 NCBI chr11:52,178,769...52,384,255
Ensembl chr11:52,178,769...52,384,255 		JBrowse link
G Neurod2 neuronal differentiation 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2385828 (PMID:16203979)		 Ensembl
RGD		 PMID:16203979 GO_REF:0000107 NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 IMP RGD PMID:11830176 RGD:633496 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Nr2e1 nuclear receptor subfamily 2, group E, member 1 acts_upstream_of_or_within ISO MGI:2151350 (PMID:12527005) RGD PMID:12527005 NCBI chr20:46,050,134...46,071,257
Ensembl chr20:46,050,414...46,073,949 		JBrowse link
G Pde8b phosphodiesterase 8B acts_upstream_of_or_within ISO (PMID:22925203) RGD PMID:22925203 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Penk proenkephalin acts_upstream_of_or_within ISO MGI:2388020 (PMID:11172058) RGD PMID:11172058 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 acts_upstream_of_or_within ISO MGI:2384784|MGI:95305 (PMID:24990923) RGD PMID:24990923 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 acts_upstream_of_or_within ISO MGI:2655190 (PMID:22221107), (PMID:22732503) RGD PMID:22221107 PMID:22732503 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Spire1 spire-type actin nucleation factor 1 acts_upstream_of_or_within ISO MGI:4310183 (PMID:24345451) RGD PMID:24345451 NCBI chr18:61,041,914...61,171,670
Ensembl chr18:61,041,290...61,171,899 		JBrowse link
G Taar4 trace amine-associated receptor 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:21,481,050...21,482,093
Ensembl chr 1:21,481,050...21,482,093 		JBrowse link
G Usp46 ubiquitin specific peptidase 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5438668 (PMID:22720038)		 Ensembl
RGD		 PMID:22720038 GO_REF:0000107 NCBI chr14:34,150,055...34,219,227
Ensembl chr14:34,150,004...34,219,227 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182154 (PMID:11907043)		 Ensembl
RGD		 PMID:11907043 GO_REF:0000107 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182182 (PMID:11907043)		 Ensembl
RGD		 PMID:11907043 GO_REF:0000107 NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471 		JBrowse link
negative regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin IMP RGD PMID:12450740 RGD:1626100 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
positive regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin IDA RGD PMID:12373548 RGD:1358453 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Cckbr cholecystokinin B receptor IMP RGD PMID:12373548 RGD:1358453 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:10366634 RGD:5508167 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Gja1 gap junction protein, alpha 1 IMP RGD PMID:22665389 RGD:7207267 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Grp gastrin releasing peptide involved_in ISS
ISO		 GO_REF:0000024
(MGI:6790352|PMID:34610277)		 UniProt
RGD		 PMID:34610277 GO_REF:0000024 MGI:6790352 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Grpr gastrin releasing peptide receptor involved_in ISS
ISO		 GO_REF:0000024
(MGI:6790352|PMID:34610277)		 UniProt
RGD		 PMID:34610277 GO_REF:0000024 MGI:6790352 NCBI chr  X:30,998,425...31,038,442
Ensembl chr  X:30,998,416...31,038,442 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:5284763|PMID:18579729)		 UniProt
RGD		 PMID:18579729 GO_REF:0000024 MGI:5284763 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Npas2 neuronal PAS domain protein 2 involved_in ISO (MGI:6282961|PMID:29163035) RGD PMID:29163035 MGI:6282961 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Penk proenkephalin IMP RGD PMID:23368426 RGD:10040949 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Ucn urocortin IDA RGD PMID:10366634 RGD:5508167 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
positive regulation of fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta IMP RGD PMID:33479380 RGD:150519900 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942 		JBrowse link
regulation of behavioral fear response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:24412220)
GO_REF:0000107		 RGD
Ensembl		 PMID:24412220 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Ephb2 Eph receptor B2 IMP RGD PMID:26354908 RGD:127285622 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Rag1 recombination activating 1 IMP RGD PMID:22964459 RGD:12907572 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:4948759|PMID:21423165)
GO_REF:0000107		 BHF-UCL
RGD
Ensembl		 PMID:21423165 GO_REF:0000024 GO_REF:0000107 MGI:4948759 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    multicellular organismal process 8921
      multicellular organismal response to stress 132
        fear response 66
          behavioral fear response + 59
          negative regulation of fear response + 1
          positive regulation of fear response + 11
          regulation of fear response + 15
Path 2
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to stress 4281
        multicellular organismal response to stress 132
          fear response 66
            behavioral fear response + 59
            negative regulation of fear response + 1
            positive regulation of fear response + 11
            regulation of fear response + 15
paths to the root