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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid metabolic process
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Accession:GO:0042573 term browser browse the term
Definition:The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid metabolism;   vitamin A1 acid metabolic process;   vitamin A1 acid metabolism


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retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:2180099|MGI:2180100|MGI:97876 (MGI:1338643|PMID:10358022), (MGI:2675573|PMID:12851412), (MGI:3510590|PMID:15193143)		 Ensembl
RGD		 PMID:10358022 PMID:12851412 PMID:15193143 PMID:21873635 GO_REF:0000107 MGI:1338643 MGI:2675573 MGI:3510590, RGD:13792537 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh6a alcohol dehydrogenase 6A (class V) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:226,823,775...226,846,005
Ensembl chr 2:226,823,730...226,846,003 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 PMID:21873635
MGI:2180102 (MGI:1338643|PMID:10358022), (MGI:1340177|PMID:10402668)
GO_REF:0000107		 RGD
Ensembl		 PMID:10358022 PMID:10402668 PMID:21873635 GO_REF:0000107 MGI:1338643 MGI:1340177, RGD:13792537 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 acts_upstream_of_or_within ISO MGI:1861722|MGI:2667220|MGI:3609477 (MGI:1336449|PMID:10191271), (MGI:2664447|PMID:12808103), (MGI:2675573|PMID:12851412), (MGI:3608158|PMID:16207763) RGD PMID:10191271 PMID:12808103 PMID:12851412 PMID:16207763 MGI:1336449 MGI:2664447 MGI:2675573 MGI:3608158 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within TAS
ISO
IDA		 MGI:1857891|MGI:2180721 (MGI:2681052|PMID:14623241), (MGI:3612223|PMID:16368932), (MGI:83148|PMID:8797830) RGD PMID:8797830 PMID:14623241 PMID:16368932 PMID:15205379 PMID:12547725 MGI:2681052 MGI:3612223 MGI:83148, RGD:1576366, RGD:1576367 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 involved_in
acts_upstream_of_or_within		 ISO (PMID:11585737)
MGI:1353450|MGI:3043947|MGI:3512079 (MGI:3608158|PMID:16207763), (MGI:3701419|PMID:17207476)		 RGD PMID:11585737 PMID:16207763 PMID:17207476 MGI:3608158 MGI:3701419 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 involved_in ISO
IBA		 (PMID:11007799)
PMID:21873635		 RGD PMID:11007799 PMID:21873635 RGD:13792537 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 acts_upstream_of_or_within NAS
ISO		 (MGI:1313226|PMID:9826179) RGD PMID:9826179 PMID:7750498 MGI:1313226, RGD:61557 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:22020119), (PMID:9716180)
(MGI:1195386|PMID:9442090), (MGI:894533|PMID:9250660)
MGI:2183292 (MGI:3522528|PMID:15531370)		 RGD PMID:9250660 PMID:9442090 PMID:9716180 PMID:15531370 PMID:22020119 MGI:1195386 MGI:3522528 MGI:894533 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22020119)		 UniProt
RGD		 PMID:22020119 GO_REF:0000024 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 involved_in ISO (PMID:11093772) RGD PMID:11093772 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 involved_in ISO (PMID:11093772) RGD PMID:11093772
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 involved_in ISO (PMID:12711469) RGD PMID:12711469 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in ISO (PMID:11093772) RGD PMID:11093772 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 involved_in ISO (PMID:11093772) RGD PMID:11093772 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 NAS RGD PMID:12390888 RGD:633755 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rbp1 retinol binding protein 1 acts_upstream_of_or_within ISO MGI:2181412|MGI:87921 (MGI:3510590|PMID:15193143) RGD PMID:15193143 MGI:3510590 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Rdh16 retinol dehydrogenase 16 IDA RGD PMID:7499345 RGD:1299624 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
G Scpep1 serine carboxypeptidase 1 IEP RGD PMID:11447226 RGD:70518 NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO
ISS		 (PMID:11304534)
GO_REF:0000024		 RGD
UniProt		 PMID:11304534 GO_REF:0000024 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rdh16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
9-cis-retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IDA RGD PMID:17167544 RGD:2306320 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 involved_in ISO
ISS		 (PMID:33495566)
GO_REF:0000024		 RGD
UniProt		 PMID:33495566 GO_REF:0000024 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 involved_in IEP
ISO
ISS
IMP		 (PMID:29240402)
GO_REF:0000024		 RGD
UniProt		 PMID:29240402 PMID:15950969 PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 acts_upstream_of_or_within
involved_in		 IEP
ISO
ISS
IEA
IMP		 (MGI:1927016|PMID:11044606), (MGI:3055622|PMID:11013254), (MGI:3692370|PMID:16241904)
(MGI:3042765|PMID:14623956)
(PMID:27759097)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097 More... GO_REF:0000024 GO_REF:0000107 MGI:1927016 MGI:3042765 MGI:3055622 MGI:3692370, RGD:6771322, RGD:6771354 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA		 RGD PMID:15950969 PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
retinoic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crabp1 cellular retinoic acid binding protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 involved_in ISO (PMID:10823918)
(MGI:894533|PMID:9250660)		 RGD PMID:9250660 PMID:10823918 MGI:894533 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 involved_in IMP
ISO		 (PMID:10823918) RGD PMID:10823918 PMID:21138835 RGD:6771354 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 involved_in ISO (PMID:14532297) RGD PMID:14532297 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842 		JBrowse link
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 involved_in ISO (PMID:26936974) RGD PMID:26936974 NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      hormone metabolic process 248
        retinoic acid metabolic process 27
          9-cis-retinoic acid metabolic process + 6
          retinoic acid biosynthetic process + 12
          retinoic acid catabolic process 5
          retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
Path 2
Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      primary metabolic process 11118
        lipid metabolic process 1454
          cellular lipid metabolic process 1062
            isoprenoid metabolic process 126
              terpenoid metabolic process 97
                diterpenoid metabolic process 87
                  retinoid metabolic process 78
                    retinoic acid metabolic process 27
                      9-cis-retinoic acid metabolic process + 6
                      retinoic acid biosynthetic process + 12
                      retinoic acid catabolic process 5
                      retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
paths to the root