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ONTOLOGY REPORT - ANNOTATIONS


Term:retinoic acid metabolic process
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Accession:GO:0042573 term browser browse the term
Definition:The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid metabolism;   vitamin A1 acid metabolic process;   vitamin A1 acid metabolism


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retinoic acid metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) IBA
ISO
PMID:21873635
MGI:2180099|MGI:2180100|MGI:97876 (MGI:1338643|PMID:10358022), (MGI:2675573|PMID:12851412), (MGI:3510590|PMID:15193143)
RGD PMID:10358022, PMID:12851412, PMID:15193143, PMID:21873635 MGI:1338643, MGI:2675573, MGI:3510590, RGD:13792537 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:243,656,568...243,687,857
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh6a alcohol dehydrogenase 6A (class V) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:243,577,086...243,599,357
Ensembl chr 2:243,577,082...243,599,400
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide IEA
ISO
IBA
GO_REF:0000107
MGI:2180102 (MGI:1338643|PMID:10358022), (MGI:1340177|PMID:10402668)
PMID:21873635
Ensembl
RGD
PMID:10358022, PMID:10402668, PMID:21873635 GO_REF:0000107, MGI:1338643, MGI:1340177, RGD:13792537 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 ISO MGI:1861722|MGI:2667220|MGI:3609477 (MGI:1336449|PMID:10191271), (MGI:2664447|PMID:12808103), (MGI:2675573|PMID:12851412), (MGI:3608158|PMID:16207763) RGD PMID:10191271, PMID:12808103, PMID:12851412, PMID:16207763 MGI:1336449, MGI:2664447, MGI:2675573, MGI:3608158 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 TAS
ISO
IDA
MGI:1857891|MGI:2180721 (MGI:2681052|PMID:14623241), (MGI:3612223|PMID:16368932), (MGI:83148|PMID:8797830) RGD PMID:8797830, PMID:14623241, PMID:16368932, PMID:15205379, PMID:12547725 MGI:2681052, MGI:3612223, MGI:83148, RGD:1576366, RGD:1576367 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 ISO (PMID:11585737)
MGI:1353450|MGI:3043947|MGI:3512079 (MGI:3608158|PMID:16207763), (MGI:3701419|PMID:17207476)
RGD PMID:11585737, PMID:16207763, PMID:17207476 MGI:3608158, MGI:3701419 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 ISO (PMID:11007799) RGD PMID:11007799 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 NAS
ISO
(MGI:1313226|PMID:9826179) RGD PMID:9826179, PMID:7750498 MGI:1313226, RGD:61557 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 ISO (PMID:22020119), (PMID:9716180)
MGI:2183292 (MGI:1195386|PMID:9442090), (MGI:3522528|PMID:15531370), (MGI:894533|PMID:9250660)
RGD PMID:9250660, PMID:9442090, PMID:9716180, PMID:15531370, PMID:22020119 MGI:1195386, MGI:3522528, MGI:894533 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 ISS
ISO
GO_REF:0000024
(PMID:22020119)
UniProt
RGD
PMID:22020119 GO_REF:0000024 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 ISO (PMID:11093772) RGD PMID:11093772 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO (PMID:11093772) RGD PMID:11093772 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 ISO (PMID:12711469) RGD PMID:12711469 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 ISO (PMID:11093772) RGD PMID:11093772 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 NAS RGD PMID:12390888 RGD:633755 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rbp1 retinol binding protein 1 ISO MGI:2181412|MGI:87921 (MGI:3510590|PMID:15193143) RGD PMID:15193143 MGI:3510590 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rdh16 retinol dehydrogenase 16 IDA RGD PMID:7499345 RGD:1299624 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G Scpep1 serine carboxypeptidase 1 IEP RGD PMID:11447226 RGD:70518 NCBI chr10:76,230,371...76,263,866
Ensembl chr10:76,230,373...76,263,866
JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IEA
ISO
GO_REF:0000107
(MGI:2662611|PMID:11876656)
Ensembl
RGD
PMID:11876656 GO_REF:0000107, MGI:2662611 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 ISO
ISS
(PMID:11304534)
GO_REF:0000024
RGD
UniProt
PMID:11304534 GO_REF:0000024 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rdh16 retinol dehydrogenase 16 ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
9-cis-retinoic acid metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IDA RGD PMID:17167544 RGD:2306320 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 IEP
ISO
ISS
IMP
(PMID:29240402)
GO_REF:0000024
RGD
UniProt
PMID:29240402, PMID:15950969, PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 IEP
ISO
ISS
IEA
IMP
(MGI:1927016|PMID:11044606), (MGI:3042765|PMID:14623956), (MGI:3055622|PMID:11013254), (MGI:3692370|PMID:16241904)
GO_REF:0000024
(PMID:27759097)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11013254, PMID:11044606, PMID:14623956, PMID:16241904, PMID:27759097, PMID:15950969, PMID:21138835 GO_REF:0000024, GO_REF:0000107, MGI:1927016, MGI:3042765, MGI:3055622, MGI:3692370, RGD:6771322, RGD:6771354 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA
RGD PMID:15950969, PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rdh10 retinol dehydrogenase 10 ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
retinoic acid catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crabp1 cellular retinoic acid binding protein 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:59,344,097...59,352,135
Ensembl chr 8:59,344,083...59,352,132
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 ISO (PMID:10823918) RGD PMID:10823918 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 IMP
ISO
(PMID:10823918) RGD PMID:10823918, PMID:21138835 RGD:6771354 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 ISO (PMID:14532297) RGD PMID:14532297 NCBI chr 1:256,369,410...256,380,649
Ensembl chr 1:256,370,850...256,378,335
JBrowse link
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 ISO (PMID:26936974) RGD PMID:26936974 NCBI chr12:17,382,749...17,387,909
Ensembl chr12:17,383,159...17,387,879
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular hormone metabolic process 127
          retinoic acid metabolic process 25
            9-cis-retinoic acid metabolic process + 6
            retinoic acid biosynthetic process + 11
            retinoic acid catabolic process 5
            retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      primary metabolic process 10900
        lipid metabolic process 1373
          cellular lipid metabolic process 1022
            isoprenoid metabolic process 117
              terpenoid metabolic process 92
                diterpenoid metabolic process 82
                  retinoid metabolic process 73
                    retinoic acid metabolic process 25
                      9-cis-retinoic acid metabolic process + 6
                      retinoic acid biosynthetic process + 11
                      retinoic acid catabolic process 5
                      retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.