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ONTOLOGY REPORT - ANNOTATIONS


Term:hormone binding
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Accession:GO:0042562 term browser browse the term
Definition:Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.


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hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase IEA Ensembl GO_REF:0000107 NCBI chr 3:52,151,500...52,255,024
Ensembl chr 3:52,151,535...52,249,612
JBrowse link
G AMHR2 anti-Mullerian hormone receptor type 2 IEA Ensembl GO_REF:0000107 NCBI chr27:1,788,420...1,795,601
Ensembl chr27:1,789,681...1,795,533
JBrowse link
G CALR calreticulin ISO RGD PMID:12603316 RGD:2326186 NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245
JBrowse link
G CRYM crystallin mu IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:24,187,073...24,204,304
Ensembl chr 6:24,187,121...24,204,304
JBrowse link
G ESR1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:15105439 PMID:17928626 RGD:1580331 RGD:5128669 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G ESR2 estrogen receptor 2 ISO 17-beta-estradiol (E2) RGD PMID:15105439 PMID:17928626 RGD:1580331 RGD:5128669 NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
JBrowse link
G GHSR growth hormone secretagogue receptor ISO PMID:10604470 UniProt PMID:10604470 RGD:625505 NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312
JBrowse link
G HK3 hexokinase 3 ISO RGD PMID:11068878 RGD:2302674 NCBI chr 4:36,471,389...36,491,757
Ensembl chr 4:36,472,949...36,529,903
JBrowse link
G LRP2 LDL receptor related protein 2 ISO RGD PMID:15131016 RGD:10053635 NCBI chr36:13,910,450...14,107,081
Ensembl chr36:13,911,865...14,107,546
JBrowse link
G MC1R melanocortin 1 receptor ISO RGD PMID:16454799 RGD:1626221 NCBI chr 5:63,694,296...63,695,249 JBrowse link
G MC4R melanocortin 4 receptor ISO RGD PMID:21527895 RGD:6478803 NCBI chr 1:16,131,829...16,132,827
Ensembl chr 1:16,131,589...16,133,079
JBrowse link
G MC5R melanocortin 5 receptor ISO RGD PMID:8179577 PMID:16454799 RGD:1626221 RGD:729030 NCBI chr 1:24,429,331...24,433,212 JBrowse link
G MCHR1 melanin concentrating hormone receptor 1 ISO RGD PMID:12505154 RGD:628540 NCBI chr10:24,526,687...24,560,948
Ensembl chr10:24,526,693...24,559,836
JBrowse link
G MLNR motilin receptor IEA Ensembl GO_REF:0000107 NCBI chr22:2,513,218...2,515,380
Ensembl chr22:2,513,218...2,515,380
JBrowse link
G MTNR1A melatonin receptor 1A ISO (PMID:10531408) BHF-UCL PMID:10531408 NCBI chr16:44,258,239...44,286,761 JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO (PMID:12547834) UniProtKB PMID:12547834 NCBI chr 7:43,382,246...43,396,464
Ensembl chr 7:43,283,418...43,396,027
JBrowse link
G NPR2 natriuretic peptide receptor 2 ISO (PMID:1672777) UniProtKB PMID:1672777 NCBI chr11:52,283,680...52,339,247
Ensembl chr11:52,321,590...52,339,249
JBrowse link
G NPR3 natriuretic peptide receptor 3 ISO (PMID:16870210) CAFA PMID:16870210 NCBI chr 4:74,794,553...74,863,344
Ensembl chr 4:74,799,857...74,862,969
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:21325249 RGD:5686350 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
JBrowse link
G PGR progesterone receptor ISO RGD PMID:11113338 RGD:1601290 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
JBrowse link
G RXFP1 relaxin family peptide receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr15:55,650,869...55,745,560
Ensembl chr15:55,651,121...55,744,496
JBrowse link
G SERPINA7 serpin family A member 7 ISO RGD PMID:1520259 RGD:1600135 NCBI chr  X:79,571,169...79,589,199
Ensembl chr  X:79,571,169...79,576,759
JBrowse link
G TTR transthyretin ISO RGD PMID:11995998 RGD:737655 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link
G UCN2 urocortin 2 ISO (PMID:11329063) UniProtKB PMID:11329063 NCBI chr20:40,551,060...40,552,920 JBrowse link
adiponectin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOR1 adiponectin receptor 1 ISO (PMID:12802337)
(MGI:3043961|PMID:12802337)
UniProtKB
MGI
PMID:12802337 MGI:3043961 NCBI chr 7:240,035...254,287
Ensembl chr 7:240,065...282,845
JBrowse link
G ADIPOR2 adiponectin receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr27:43,739,269...43,840,116
Ensembl chr27:43,741,679...43,878,467
JBrowse link
G CDH13 cadherin 13 IEA Ensembl GO_REF:0000107 NCBI chr 5:68,491,156...69,586,119
Ensembl chr 5:68,492,022...69,489,255
JBrowse link
adrenomedullin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCRL calcitonin receptor like receptor IEA Ensembl GO_REF:0000107 NCBI chr36:29,342,869...29,442,977
Ensembl chr36:29,345,236...29,442,732
JBrowse link
G RAMP2 receptor activity modifying protein 2 ISO (PMID:22102369) UniProtKB PMID:22102369 NCBI chr 9:20,250,711...20,252,485 JBrowse link
androgen binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor ISS
IEA
UniProtKB
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
G TSPO translocator protein ISO RGD PMID:8918981 RGD:2317178 NCBI chr10:22,388,498...22,399,329
Ensembl chr10:22,274,405...22,399,297
JBrowse link
calcitonin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCR calcitonin receptor NOT ISO (PMID:15563840)
(PMID:7588285)
(PMID:8078488)
(PMID:7769107), (PMID:8078488)
RGD
UniProtKB
PMID:7588285 PMID:7723741 PMID:7769107 PMID:8078488 PMID:15563840 RGD:2303052 NCBI chr14:18,923,116...19,074,904
Ensembl chr14:18,923,116...19,074,904
JBrowse link
calcitonin gene-related peptide binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAMP1 receptor activity modifying protein 1 IEA Ensembl GO_REF:0000107 NCBI chr25:48,431,136...48,466,070
Ensembl chr25:48,437,919...48,466,070
JBrowse link
choriogonadotropin hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LHCGR luteinizing hormone/choriogonadotropin receptor IEA Ensembl GO_REF:0000107 NCBI chr10:50,540,706...50,594,336
Ensembl chr10:50,541,960...50,598,036
JBrowse link
corticotropin-releasing hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHBP corticotropin releasing hormone binding protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:29,726,316...29,737,748
Ensembl chr 3:29,705,031...29,758,111
JBrowse link
G LOC610380 corticotropin-releasing factor receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:9,708,696...9,763,281 JBrowse link
epidermal growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
JBrowse link
G SEC61B SEC61 translocon subunit beta IEA Ensembl GO_REF:0000107 NCBI chr11:56,279,564...56,298,593
Ensembl chr11:56,251,636...56,286,291
JBrowse link
G SHC1 SHC adaptor protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276
JBrowse link
insulin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2CD2L C2CD2 like IEA Ensembl GO_REF:0000107 NCBI chr 5:14,746,613...14,755,952
Ensembl chr 5:14,747,208...14,755,925
JBrowse link
G IDE insulin degrading enzyme IEA Ensembl GO_REF:0000107 NCBI chr28:6,844,480...6,967,713
Ensembl chr28:6,844,055...6,967,713
JBrowse link
G IGF1R insulin like growth factor 1 receptor IEA Ensembl GO_REF:0000107 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G INSR insulin receptor IEA Ensembl GO_REF:0000107 NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
peptide hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1R1 ADCYAP receptor type I IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:43,707,683...43,761,166
Ensembl chr14:43,701,745...43,756,571
JBrowse link
G ANXA5 annexin A5 ISO RGD PMID:1386737 RGD:7241860 NCBI chr19:18,419,936...18,450,088
Ensembl chr19:18,407,587...18,570,378
JBrowse link
G AVPR1A arginine vasopressin receptor 1A ISO RGD PMID:12942143 RGD:1358326 NCBI chr10:6,266,217...6,269,662
Ensembl chr10:6,265,998...6,269,662
JBrowse link
G AVPR1B arginine vasopressin receptor 1B ISO RGD PMID:7624319 PMID:19047484 RGD:2312649 RGD:61542 NCBI chr38:2,440,574...2,446,037
Ensembl chr38:2,440,615...2,446,037
JBrowse link
G CCKAR cholecystokinin A receptor IEA Ensembl GO_REF:0000107 NCBI chr 3:84,010,700...84,019,066
Ensembl chr 3:84,010,205...84,021,293
JBrowse link
G CCKBR cholecystokinin B receptor IEA Ensembl GO_REF:0000107 NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:43,366,849...43,414,398
Ensembl chr14:43,368,340...43,415,142
JBrowse link
G EBI3 Epstein-Barr virus induced 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:55,382,975...55,391,252
Ensembl chr20:55,383,247...55,390,336
JBrowse link
G EDNRB endothelin receptor type B IEA Ensembl GO_REF:0000107 NCBI chr22:31,415,324...31,438,772
Ensembl chr22:31,417,308...31,437,587
JBrowse link
G FSHR follicle stimulating hormone receptor ISO RGD PMID:16899567 RGD:4140424 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474
JBrowse link
G GALR1 galanin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:2,721,326...2,742,012
Ensembl chr 1:2,729,331...2,742,231
JBrowse link
G GALR2 galanin receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 9:4,559,710...4,562,474
Ensembl chr 9:4,560,067...4,562,463
JBrowse link
G GALR3 galanin receptor 3 IEA Ensembl GO_REF:0000107 NCBI chr10:26,814,942...26,819,725
Ensembl chr10:26,814,942...26,816,727
JBrowse link
G GCGR glucagon receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:455,744...463,070
Ensembl chr 9:344,438...459,925
JBrowse link
G GHR growth hormone receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:67,021,821...67,245,499
Ensembl chr 4:67,022,252...67,290,473
JBrowse link
G GHRHR growth hormone releasing hormone receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:43,626,862...43,638,737
Ensembl chr14:43,626,845...43,638,753
JBrowse link
G GHSR growth hormone secretagogue receptor ISO RGD PMID:17109695 RGD:1624382 NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312
JBrowse link
G GIPR gastric inhibitory polypeptide receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:109,898,617...109,909,331
Ensembl chr 1:109,899,874...109,909,410
JBrowse link
G GLP1R glucagon like peptide 1 receptor ISO RGD PMID:1326760 RGD:727535 NCBI chr12:7,999,963...8,030,335
Ensembl chr12:7,999,997...8,025,048
JBrowse link
G GLP2R glucagon like peptide 2 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:34,267,270...34,317,525
Ensembl chr 5:34,266,966...34,318,472
JBrowse link
G GUCY2C guanylate cyclase 2C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr27:31,915,552...31,989,748
Ensembl chr27:31,917,604...31,989,551
JBrowse link
G HCRTR1 hypocretin receptor 1 ISO RGD PMID:12890892 RGD:1642020 NCBI chr 2:69,484,776...69,493,956
Ensembl chr 2:69,480,199...69,494,005
JBrowse link
G HCRTR2 hypocretin receptor 2 ISO RGD PMID:12890892 RGD:1642020 NCBI chr12:22,517,482...22,623,358
Ensembl chr12:22,517,482...22,623,358
JBrowse link
G IDE insulin degrading enzyme ISO RGD PMID:15494400 RGD:1626705 NCBI chr28:6,844,480...6,967,713
Ensembl chr28:6,844,055...6,967,713
JBrowse link
G INHBA inhibin subunit beta A IEA Ensembl GO_REF:0000107 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
G LEPR leptin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:44,684,118...44,775,626
Ensembl chr 5:44,688,109...44,775,636
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO human chorionic gonadotropin
binding is to the hCG alpha subunit; beta subunit included in complex via interaction with alpha
RGD PMID:1714448 PMID:2601325 PMID:2925659 PMID:3782111 PMID:15901736 RGD:2292553 RGD:2292578 RGD:2292580 RGD:2292582 RGD:2292594 NCBI chr10:50,540,706...50,594,336
Ensembl chr10:50,541,960...50,598,036
JBrowse link
G LOC489082 neuropeptide Y receptor type 4 ISO (PMID:7493937), (PMID:7592911) GO_Central PMID:7493937 PMID:7592911 NCBI chr 4:34,816,566...34,820,774 JBrowse link
G LOC610380 corticotropin-releasing factor receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:9,708,696...9,763,281 JBrowse link
G MC3R melanocortin 3 receptor ISO RGD PMID:17023527 RGD:1600765 NCBI chr24:41,492,371...41,494,033
Ensembl chr24:41,492,371...41,494,033
JBrowse link
G MC4R melanocortin 4 receptor ISO RGD PMID:17023527 RGD:1600765 NCBI chr 1:16,131,829...16,132,827
Ensembl chr 1:16,131,589...16,133,079
JBrowse link
G NPR1 natriuretic peptide receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:43,382,246...43,396,464
Ensembl chr 7:43,283,418...43,396,027
JBrowse link
G NPR2 natriuretic peptide receptor 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr11:52,283,680...52,339,247
Ensembl chr11:52,321,590...52,339,249
JBrowse link
G NPR3 natriuretic peptide receptor 3 IEA Ensembl GO_REF:0000107 NCBI chr 4:74,794,553...74,863,344
Ensembl chr 4:74,799,857...74,862,969
JBrowse link
G OXTR oxytocin receptor ISO RGD PMID:15821089 RGD:1579892 NCBI chr20:9,358,797...9,382,308
Ensembl chr20:9,358,916...9,378,343
JBrowse link
G PRLHR prolactin releasing hormone receptor ISO RGD PMID:15854142 RGD:1641829 NCBI chr28:28,950,300...28,956,140
Ensembl chr28:28,954,469...28,955,581
JBrowse link
G PRLR prolactin receptor IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 4:73,147,919...73,280,970
Ensembl chr 4:73,110,858...73,273,916
JBrowse link
G PTH1R parathyroid hormone 1 receptor ISS
IBA
IEA
(PMID:21873635) UniProtKB
GO_Central
Ensembl
PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr20:41,905,265...41,924,712
Ensembl chr20:41,905,273...41,925,794
JBrowse link
G PTH2R parathyroid hormone 2 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr37:16,656,573...16,758,313
Ensembl chr37:16,678,002...16,734,220
JBrowse link
G RXFP2 relaxin family peptide receptor 2 ISO RGD PMID:15956681 RGD:1600172 NCBI chr25:8,307,850...8,368,438
Ensembl chr25:8,307,850...8,368,834
JBrowse link
G SCTR secretin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:30,505,059...30,577,371
Ensembl chr19:30,526,055...30,577,075
JBrowse link
G SLC40A1 solute carrier family 40 member 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr37:308,054...329,037
Ensembl chr37:303,104...368,865
JBrowse link
G VIPR1 vasoactive intestinal peptide receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:11,635,809...11,666,926
Ensembl chr23:11,635,394...11,666,936
JBrowse link
G VIPR2 vasoactive intestinal peptide receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:20,925,032...20,987,513
Ensembl chr16:20,927,991...20,987,785
JBrowse link
steroid hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 IEA Ensembl GO_REF:0000107 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167
JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 IEA Ensembl GO_REF:0000107 NCBI chr38:22,023,176...22,080,656
Ensembl chr38:22,023,221...22,080,604
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
JBrowse link
G SULT2B1 sulfotransferase family 2B member 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:107,705,568...107,721,160
Ensembl chr 1:107,705,576...107,720,876
JBrowse link
thyroid hormone binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 IEA Ensembl GO_REF:0000107 NCBI chr 3:40,130,904...40,168,686
Ensembl chr 3:40,132,726...40,168,664
JBrowse link
G CRYM crystallin mu IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:24,187,073...24,204,304
Ensembl chr 6:24,187,121...24,204,304
JBrowse link
G CTSH cathepsin H ISS UniProt GO_REF:0000024 NCBI chr 3:58,103,284...58,113,958
Ensembl chr 3:58,103,291...58,113,718
JBrowse link
G PKM pyruvate kinase M1/2 ISO PMID:1883388 CAFA PMID:1883388 RGD:12793012 NCBI chr30:35,712,853...35,737,643 JBrowse link
G THRA thyroid hormone receptor alpha IEA Ensembl GO_REF:0000107 NCBI chr 9:22,469,466...22,493,445
Ensembl chr 9:22,468,594...22,493,445
JBrowse link
G THRB thyroid hormone receptor beta IEA Ensembl GO_REF:0000107 NCBI chr23:19,278,650...19,648,547
Ensembl chr23:19,277,493...19,660,283
JBrowse link
G TTR transthyretin IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17054
    binding 15303
      hormone binding 89
        abscisic acid binding 0
        adiponectin binding 3
        androgen binding 2
        auxin binding 0
        choriogonadotropin hormone binding 1
        cytokinin binding 0
        ecdysone binding 0
        epidermal growth factor binding 3
        estrogen binding 0
        gibberellin binding 0
        juvenile hormone binding 0
        peptide hormone binding + 53
        steroid hormone binding + 5
        thyroid hormone binding 7
paths to the root