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ONTOLOGY REPORT - ANNOTATIONS


Term:superoxide anion generation
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Accession:GO:0042554 term browser browse the term
Definition:The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
Synonyms:exact_synonym: superoxide release


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superoxide anion generation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain ISO
IBA
IMP
(PMID:2243141)
PMID:21873635
PMID:8798532
RGD PMID:2243141, PMID:21873635, PMID:8798532 RGD:13792537, RGD:2317869 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain ISO
IBA
(PMID:12042318)
PMID:21873635
RGD PMID:12042318, PMID:21873635 RGD:13792537 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Duox1 dual oxidase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Duox2 dual oxidase 2 ISO
IBA
UniProtKB:Q1HG43 (PMID:22814254)
PMID:21873635
RGD PMID:22814254, PMID:21873635 RGD:13792537 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Edn1 endothelin 1 IDA RGD PMID:16788136 RGD:4892602 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:2547247)
MGI:MGI:1934143 (MGI:MGI:1354608|PMID:10725280), (MGI:MGI:1930845|PMID:11156938)
RGD PMID:2547247, PMID:10725280, PMID:11156938 MGI:MGI:1354608, MGI:MGI:1930845 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO
IBA
(MGI:MGI:1196082|PMID:9490028)
PMID:21873635
RGD PMID:9490028, PMID:21873635 MGI:MGI:1196082, RGD:13792537 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nox1 NADPH oxidase 1 IMP
IBA
ISO
IEA
PMID:10485709
PMID:21873635
MGI:MGI:3616995 (MGI:MGI:2449827|PMID:12473664), (MGI:MGI:3796728|PMID:18397177)
(PMID:10485709), (PMID:18023288)
GO_REF:0000107
RGD
Ensembl
PMID:10485709, PMID:12473664, PMID:18023288, PMID:18397177, PMID:10485709, PMID:21873635 GO_REF:0000107, MGI:MGI:2449827, MGI:MGI:3796728, RGD:633401, RGD:13792537 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox3 NADPH oxidase 3 ISO
IBA
(MGI:MGI:3512869|PMID:15326186)
PMID:21873635
RGD PMID:15326186, PMID:21873635 MGI:MGI:3512869, RGD:13792537 NCBI chr 1:44,550,994...44,615,760
Ensembl chr 1:44,550,994...44,615,760
JBrowse link
G Nox4 NADPH oxidase 4 ISO
IBA
ISS
(MGI:MGI:3694159|PMID:10869423)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:10869423, PMID:21873635 GO_REF:0000024, MGI:MGI:3694159, RGD:13792537 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Noxa1 NADPH oxidase activator 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:2,299,676...2,309,491
Ensembl chr 3:2,299,691...2,309,179
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:72,395,194...72,401,254
Ensembl chr 3:72,395,218...72,401,318
JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:3522379|PMID:15317809) RGD PMID:15317809 MGI:MGI:3522379 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 ISO MGI:MGI:1857344|MGI:MGI:1857480|MGI:MGI:2447406|MGI:MGI:2679331 (MGI:MGI:3625564|PMID:15781740), (MGI:MGI:3653322|PMID:16677818), (MGI:MGI:3654558|PMID:10212301) RGD PMID:10212301, PMID:15781740, PMID:16677818 MGI:MGI:3625564, MGI:MGI:3653322, MGI:MGI:3654558 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tafa4 TAFA chemokine like family member 4 ISO (MGI:MGI:6282963|PMID:25109685) RGD PMID:25109685 MGI:MGI:6282963 NCBI chr 4:129,196,658...129,430,438
Ensembl chr 4:129,196,659...129,430,251
JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor ISO (PMID:15207272) RGD PMID:15207272 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant ISO
IEA
MGI:MGI:2180086 (MGI:MGI:1930064|PMID:11168643)
GO_REF:0000107
RGD
Ensembl
PMID:11168643 GO_REF:0000107, MGI:MGI:1930064 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IMP RGD PMID:24601882 RGD:39128160 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Crp C-reactive protein IDA RGD PMID:9767445 RGD:9586000 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Pon3 paraoxonase 3 ISO (MGI:MGI:5543365|PMID:22441669) RGD PMID:22441669 MGI:MGI:5543365 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:21376054 RGD:5129173 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:21076237 RGD:5129195 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:O88536 (PMID:11316806) RGD PMID:11316806 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Cd177 CD177 molecule ISO UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:82,964,683...82,987,306
Ensembl chr 1:82,964,683...82,987,253
JBrowse link
G Clec7a C-type lectin domain containing 7A ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Crp C-reactive protein ISO (PMID:24141169) RGD PMID:24141169 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5586806|PMID:10725737)
Ensembl
RGD
PMID:10725737 GO_REF:0000107, MGI:MGI:5586806 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cyba cytochrome b-245 alpha chain IMP RGD PMID:15036821 RGD:8693734 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:22966991 RGD:7204494 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO
ISS
(PMID:11714832)
GO_REF:0000024
RGD
UniProt
PMID:11714832 GO_REF:0000024 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fpr2 formyl peptide receptor 2 ISO UniProtKB:P05067:PRO_0000000092 (MGI:MGI:5905278|PMID:11316806) RGD PMID:11316806 MGI:MGI:5905278 NCBI chr 1:59,800,558...59,809,507
Ensembl chr 1:59,800,984...59,802,401
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(MGI:MGI:5009187|PMID:11408560)
GO_REF:0000024
RGD
BHF-UCL
PMID:11408560 GO_REF:0000024, MGI:MGI:5009187 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:24935944 RGD:14985214 NCBI chr12:39,822,814...39,851,093
Ensembl chr12:39,822,637...39,850,567
JBrowse link
G Il18 interleukin 18 IMP RGD PMID:19497959 RGD:4889403 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Itgam integrin subunit alpha M ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407)
(MGI:MGI:3812233|PMID:18685038), (MGI:MGI:3814938|PMID:18981141)
RGD PMID:18685038, PMID:18981141, PMID:21193407 MGI:MGI:3812233, MGI:MGI:3814938 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Mapt microtubule-associated protein tau ISO
IEA
(PMID:22920254)
GO_REF:0000107
RGD
Ensembl
PMID:22920254 GO_REF:0000107 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO (PMID:24141169) RGD PMID:24141169 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
ISS
(PMID:19801500)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19801500 GO_REF:0000024, GO_REF:0000107 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Sod1 superoxide dismutase 1 ISO (PMID:18219391) RGD PMID:18219391 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Syk spleen associated tyrosine kinase IEA
ISO
GO_REF:0000107
(PMID:19358895)
Ensembl
RGD
PMID:19358895 GO_REF:0000107 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
ISS
(PMID:22073128)
GO_REF:0000024
RGD
UniProt
PMID:22073128 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp ISO (MGI:MGI:3812233|PMID:18685038) RGD PMID:18685038 MGI:MGI:3812233 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
regulation of superoxide anion generation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase ISO
ISS
(MGI:MGI:4414596|PMID:19797524)
GO_REF:0000024
RGD
UniProt
PMID:19797524 GO_REF:0000024, MGI:MGI:4414596 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular metabolic process 11085
        reactive oxygen species metabolic process 310
          superoxide metabolic process 69
            superoxide anion generation 42
              negative regulation of superoxide anion generation 5
              positive regulation of superoxide anion generation 25
              regulation of superoxide anion generation + 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.