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ONTOLOGY REPORT - ANNOTATIONS

Term:superoxide anion generation
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Accession:GO:0042554 term browser browse the term
Definition:The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
Synonyms:exact_synonym: superoxide release


show annotations for term's descendants           Sort by:
superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2180086 (PMID:11168643)		 Ensembl
RGD		 PMID:11168643 GO_REF:0000107 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in ISO
IMP
IEA
IBA		 (PMID:2243141)
PMID:8798532
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:2243141 PMID:8798532 GO_REF:0000033 GO_REF:0000107, RGD:2317869 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain involved_in ISO
IBA		 (PMID:12042318)
GO_REF:0000033		 RGD
GO_Central		 PMID:12042318 GO_REF:0000033 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Duox1 dual oxidase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Duox2 dual oxidase 2 involved_in ISO
IBA		 UniProtKB:Q1HG43 (PMID:22814254)
GO_REF:0000033		 RGD
GO_Central		 PMID:22814254 GO_REF:0000033 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Edn1 endothelin 1 IDA RGD PMID:16788136 RGD:4892602 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 acts_upstream_of_or_within_positive_effect
involved_in		 ISO
IBA		 (PMID:2547247)
GO_REF:0000033
MGI:1934143 (PMID:10725280), (PMID:11156938)		 RGD
GO_Central		 PMID:2547247 PMID:10725280 PMID:11156938 GO_REF:0000033 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:8280052)
GO_REF:0000107
GO_REF:0000033
(PMID:9490028)		 RGD
Ensembl
GO_Central		 PMID:8280052 PMID:9490028 GO_REF:0000033 GO_REF:0000107 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 involved_in ISO
IBA		 (PMID:8280052)
GO_REF:0000033		 RGD
GO_Central		 PMID:8280052 GO_REF:0000033 NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389 		JBrowse link
G Nox1 NADPH oxidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IMP
IBA		 GO_REF:0000107
(PMID:10485709), (PMID:18023288)
GO_REF:0000033
MGI:3616995 (PMID:18397177)		 Ensembl
RGD
GO_Central		 PMID:10485709 PMID:18023288 PMID:18397177 PMID:10485709 GO_REF:0000033 GO_REF:0000107, RGD:633401 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox3 NADPH oxidase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851 		JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(MGI:3694159|PMID:10869423)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:10869423 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3694159 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Noxa1 NADPH oxidase activator 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:7,895,488...7,907,011
Ensembl chr 3:7,895,488...7,905,967 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061 		JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102 		JBrowse link
G Sh3pxd2a SH3 and PX domains 2A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166 		JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:15317809) RGD PMID:15317809 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857344|MGI:1857480|MGI:2447406|MGI:2679331 (PMID:10212301), (PMID:15781740), (PMID:16677818) RGD PMID:10212301 PMID:15781740 PMID:16677818 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tafa4 TAFA chemokine like family member 4 involved_in ISO (MGI:6282963|PMID:25109685) RGD PMID:25109685 MGI:6282963 NCBI chr 4:129,437,466...129,671,320
Ensembl chr 4:129,437,467...129,671,249 		JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180086 (PMID:11168643)		 Ensembl
RGD		 PMID:11168643 GO_REF:0000107 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IMP RGD PMID:24601882 RGD:39128160 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Crp C-reactive protein IDA RGD PMID:9767445 RGD:9586000 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Pon3 paraoxonase 3 involved_in ISO
IEA		 (MGI:5543365|PMID:22441669)
(PMID:22441669)
GO_REF:0000107		 RGD
Ensembl		 PMID:22441669 GO_REF:0000107 MGI:5543365 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:21376054 RGD:5129173 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:21076237 RGD:5129195 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:O88536 (PMID:11316806) RGD PMID:11316806 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cd177 CD177 molecule involved_in ISO UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621 		JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Crp C-reactive protein involved_in ISO (PMID:24141169) RGD PMID:24141169 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5586806|PMID:10725737)		 Ensembl
RGD		 PMID:10725737 GO_REF:0000107 MGI:5586806 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyba cytochrome b-245 alpha chain IMP RGD PMID:15036821 RGD:8693734 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:22966991 RGD:7204494 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 IMP RGD PMID:26682942 RGD:329961560 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS		 (PMID:11714832)
GO_REF:0000024		 RGD
UniProt		 PMID:11714832 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Fpr2 formyl peptide receptor 2 involved_in ISO UniProtKB:P05067-PRO_0000000092 (MGI:5905278|PMID:11316806)
UniProtKB:P05067-PRO_0000000092 (PMID:11316806)		 RGD PMID:11316806 MGI:5905278 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019 		JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5009187|PMID:11408560)		 BHF-UCL
RGD		 PMID:11408560 GO_REF:0000024 MGI:5009187 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:24935944 RGD:14985214 NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141 		JBrowse link
G Il18 interleukin 18 IMP RGD PMID:19497959 RGD:4889403 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407)
(PMID:18685038), (PMID:18981141)
(MGI:3812233|PMID:18685038), (MGI:3814938|PMID:18981141)		 RGD PMID:18685038 PMID:18981141 PMID:21193407 MGI:3812233 MGI:3814938 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Mapt microtubule-associated protein tau involved_in ISO (PMID:22920254) RGD PMID:22920254 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nox1 NADPH oxidase 1 IMP RGD PMID:24294978 PMID:26682942 RGD:329955573, RGD:329961560 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 involved_in ISO (PMID:24141169) RGD PMID:24141169 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA
ISS		 (PMID:19801500)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19801500 GO_REF:0000024 GO_REF:0000107 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Sod1 superoxide dismutase 1 involved_in ISO
IEA		 (PMID:18219391)
GO_REF:0000107		 RGD
Ensembl		 PMID:18219391 GO_REF:0000107 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA		 (PMID:19358895)
GO_REF:0000107		 RGD
Ensembl		 PMID:19358895 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:22073128)
GO_REF:0000024		 RGD
UniProt		 PMID:22073128 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (MGI:3812233|PMID:18685038)
(PMID:18685038)		 RGD PMID:18685038 MGI:3812233 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syk spleen associated tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:4414596|PMID:19797524)		 UniProt
RGD		 PMID:19797524 GO_REF:0000024 MGI:4414596 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20133
    cellular process 19325
      metabolic process 12307
        reactive oxygen species metabolic process 268
          superoxide metabolic process 75
            superoxide anion generation 45
              negative regulation of superoxide anion generation 4
              positive regulation of superoxide anion generation 27
              regulation of superoxide anion generation + 30
paths to the root