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ONTOLOGY REPORT - ANNOTATIONS


Term:hemoglobin biosynthetic process
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Accession:GO:0042541 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
Synonyms:exact_synonym: haemoglobin biosynthesis;   haemoglobin biosynthetic process;   hemoglobin anabolism;   hemoglobin biosynthesis;   hemoglobin formation;   hemoglobin synthesis


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hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in IEA
ISO
IBA
ISS
GO_REF:0000107
(MGI:3694153|PMID:9446639)
PMID:21873635
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9446639 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3694153, RGD:13792537 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Epo erythropoietin acts_upstream_of_or_within ISO (MGI:3762687|PMID:17300687) RGD PMID:17300687 MGI:3762687 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857719 (MGI:3695187|PMID:16787915)
Ensembl
RGD
PMID:16787915 GO_REF:0000107 MGI:3695187 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Inha inhibin subunit alpha involved_in ISO
ISS
(PMID:1310063)
GO_REF:0000024
RGD
UniProt
PMID:1310063 GO_REF:0000024 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
JBrowse link
G Inhba inhibin subunit beta A involved_in ISO
ISS
(PMID:1310063)
GO_REF:0000024
RGD
UniProt
PMID:1310063 GO_REF:0000024 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Snx3 sorting nexin 3 acts_upstream_of_or_within ISO (MGI:5495606|PMID:23416069) RGD PMID:23416069 MGI:5495606 NCBI chr20:45,992,446...46,025,361
Ensembl chr20:45,992,720...46,025,379
JBrowse link
negative regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3687799|PMID:11050009)
UniProt
RGD
PMID:11050009 GO_REF:0000024 MGI:3687799 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
positive regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (PMID:22085049), (PMID:28808058) RGD PMID:22085049 PMID:28808058 NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753
JBrowse link
G Klf4 Kruppel like factor 4 involved_in ISO (PMID:21539536) RGD PMID:21539536 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Ldb1 LIM domain binding 1 involved_in ISO (MGI:4834059|PMID:20570862) RGD PMID:20570862 MGI:4834059 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in IDA PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Slc25a37 solute carrier family 25 member 37 involved_in ISS
ISO
GO_REF:0000024
(MGI:4361776|PMID:19805291)
UniProt
RGD
PMID:19805291 GO_REF:0000024 MGI:4361776 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) RGD PMID:28495915 MGI:6450351 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 acts_upstream_of_or_within ISO MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      primary metabolic process 10531
        protein metabolic process 5891
          hemoglobin metabolic process 21
            hemoglobin biosynthetic process 15
              negative regulation of hemoglobin biosynthetic process 1
              positive regulation of hemoglobin biosynthetic process 6
              regulation of hemoglobin biosynthetic process + 8
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11335
        organonitrogen compound metabolic process 6802
          protein metabolic process 5891
            hemoglobin metabolic process 21
              hemoglobin biosynthetic process 15
                negative regulation of hemoglobin biosynthetic process 1
                positive regulation of hemoglobin biosynthetic process 6
                regulation of hemoglobin biosynthetic process + 8
paths to the root