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ONTOLOGY REPORT - ANNOTATIONS


Term:hemoglobin biosynthetic process
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Accession:GO:0042541 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
Synonyms:exact_synonym: haemoglobin biosynthesis;   haemoglobin biosynthetic process;   hemoglobin anabolism;   hemoglobin biosynthesis;   hemoglobin formation;   hemoglobin synthesis


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hemoglobin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 ISO
IBA
IEA
ISS
(MGI:MGI:3694153|PMID:9446639)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:9446639, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3694153, RGD:13792537 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Epo erythropoietin ISO (MGI:MGI:3762687|PMID:17300687) RGD PMID:17300687 MGI:MGI:3762687 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA
MGI:MGI:1857719 (MGI:MGI:3695187|PMID:16787915)
GO_REF:0000107
RGD
Ensembl
PMID:16787915 GO_REF:0000107, MGI:MGI:3695187 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Inha inhibin subunit alpha ISO
ISS
(PMID:1310063)
GO_REF:0000024
RGD
UniProt
PMID:1310063 GO_REF:0000024 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Inhba inhibin subunit beta A ISO
ISS
(PMID:1310063)
GO_REF:0000024
RGD
UniProt
PMID:1310063 GO_REF:0000024 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Snx3 sorting nexin 3 ISO (MGI:MGI:5495606|PMID:23416069) RGD PMID:23416069 MGI:MGI:5495606 NCBI chr20:47,225,382...47,263,390
Ensembl chr20:47,225,619...47,263,390
JBrowse link
negative regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO
ISS
(MGI:MGI:3687799|PMID:11050009)
GO_REF:0000024
RGD
UniProt
PMID:11050009 GO_REF:0000024, MGI:MGI:3687799 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
positive regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf4 Kruppel like factor 4 ISO (PMID:21539536) RGD PMID:21539536 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Ldb1 LIM domain binding 1 ISO (MGI:MGI:4834059|PMID:20570862) RGD PMID:20570862 MGI:MGI:4834059 NCBI chr 1:265,772,729...265,798,442
Ensembl chr 1:265,785,409...265,798,167
JBrowse link
G Prmt1 protein arginine methyltransferase 1 IDA PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 1:100,971,132...100,980,411
Ensembl chr 1:100,971,273...100,980,340
JBrowse link
G Slc6a9 solute carrier family 6 member 9 IEA
ISO
GO_REF:0000107
(MGI:MGI:6450351|PMID:28495915)
Ensembl
RGD
PMID:28495915 GO_REF:0000107, MGI:MGI:6450351 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO MGI:MGI:1353448|MGI:MGI:95513 (MGI:MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:MGI:3581470 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Fech ferrochelatase ISO MGI:MGI:1353448|MGI:MGI:95513 (MGI:MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:MGI:3581470 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      primary metabolic process 10920
        protein metabolic process 6228
          hemoglobin metabolic process 19
            hemoglobin biosynthetic process 13
              negative regulation of hemoglobin biosynthetic process 1
              positive regulation of hemoglobin biosynthetic process 4
              regulation of hemoglobin biosynthetic process + 6
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        organonitrogen compound metabolic process 7153
          protein metabolic process 6228
            hemoglobin metabolic process 19
              hemoglobin biosynthetic process 13
                negative regulation of hemoglobin biosynthetic process 1
                positive regulation of hemoglobin biosynthetic process 4
                regulation of hemoglobin biosynthetic process + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.