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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-delta T cell differentiation
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Accession:GO:0042492 term browser browse the term
Definition:The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: gamma-delta T lymphocyte differentiation
 related_synonym: gamma-delta T cell development


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gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag2 jagged canonical Notch ligand 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10383933) 		Ensembl
RGD		 PMID:10383933 GO_REF:0000107 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of ISO MGI:1857211 (PMID:7807014) RGD PMID:7807014 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of ISO MGI:2181288 (PMID:7807014) RGD PMID:7807014 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO
IEA 		(PMID:17218525), (PMID:30413363)
GO_REF:0000107 		RGD
Ensembl		 PMID:17218525 PMID:30413363 GO_REF:0000107 NCBI chr13:47,383,145...47,427,572
Ensembl chr13:44,831,085...44,875,762 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of ISO
IEA 		MGI:103035 (PMID:15294943)
GO_REF:0000107 		RGD
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of ISO
IEA 		MGI:103036 (PMID:15294943)
GO_REF:0000107 		RGD
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of ISO
IEA 		MGI:1857421|MGI:2384078 (PMID:7477352), (PMID:8790395)
GO_REF:0000107 		RGD
Ensembl		 PMID:7477352 PMID:8790395 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (PMID:30413363) RGD PMID:30413363 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
CD8-positive, gamma-delta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr9 C-C motif chemokine receptor 9 acts_upstream_of_or_within ISO
IEA 		MGI:3654108 (PMID:25348153)
GO_REF:0000107 		RGD
Ensembl		 PMID:25348153 GO_REF:0000107 NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:123,395,813...123,413,969 		JBrowse link
G Gpr18 G protein-coupled receptor 18 acts_upstream_of_or_within ISO MGI:5708707 (PMID:25348153) RGD PMID:25348153 NCBI chr15:105,404,062...105,407,812
Ensembl chr15:98,997,259...99,001,470 		JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:18064301) RGD PMID:18064301 NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:11859104 RGD:625608 NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:1857211 (PMID:7807014) RGD PMID:7807014 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:23562159) 		UniProt
Ensembl
RGD		 PMID:23562159 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO 		GO_REF:0000024
(PMID:19015308) 		UniProt
RGD		 PMID:19015308 GO_REF:0000024 NCBI chr 7:136,455,900...136,501,384
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:7807014) RGD PMID:7807014 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO
IEA 		(PMID:23562159)
GO_REF:0000107 		RGD
Ensembl		 PMID:23562159 GO_REF:0000107 NCBI chr13:47,383,145...47,427,572
Ensembl chr13:44,831,085...44,875,762 		JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (PMID:23562159) RGD PMID:23562159 NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO
IEA 		MGI:103035 (PMID:15294943)
GO_REF:0000107 		RGD
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO
IEA 		MGI:103036 (PMID:15294943)
GO_REF:0000107 		RGD
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within ISO
IEA 		MGI:1857421|MGI:2384078 (PMID:7477352), (PMID:8790395)
GO_REF:0000107 		RGD
Ensembl		 PMID:7477352 PMID:8790395 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr3 early growth response 3 acts_upstream_of_or_within ISO
IEA 		(PMID:21737317)
GO_REF:0000107 		RGD
Ensembl		 PMID:21737317 GO_REF:0000107 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within ISO (PMID:21737317) RGD PMID:21737317 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Sox13 SRY-box transcription factor 13 acts_upstream_of_or_within ISO
IEA 		(PMID:21737317)
GO_REF:0000107 		RGD
Ensembl		 PMID:21737317 GO_REF:0000107 NCBI chr13:47,383,145...47,427,572
Ensembl chr13:44,831,085...44,875,762 		JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (PMID:23562159) RGD PMID:23562159 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3132
      leukocyte activation 1084
        lymphocyte activation 878
          T cell activation 623
            T cell differentiation 337
              gamma-delta T cell differentiation 17
                gamma-delta T cell differentiation involved in immune response 0
                gamma-delta T cell lineage commitment 0
                gamma-delta intraepithelial T cell differentiation + 3
                negative regulation of gamma-delta T cell differentiation 0
                positive regulation of gamma-delta T cell differentiation 10
                regulation of gamma-delta T cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular developmental process 4838
        cell differentiation 4837
          cell development 3352
            hemopoiesis 1084
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 455
                    T cell differentiation 337
                      gamma-delta T cell differentiation 17
                        gamma-delta T cell differentiation involved in immune response 0
                        gamma-delta T cell lineage commitment 0
                        gamma-delta intraepithelial T cell differentiation + 3
                        negative regulation of gamma-delta T cell differentiation 0
                        positive regulation of gamma-delta T cell differentiation 10
                        regulation of gamma-delta T cell differentiation + 13
paths to the root