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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-delta T cell differentiation
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Accession:GO:0042492 term browser browse the term
Definition:The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: gamma-delta T lymphocyte differentiation
 related_synonym: gamma-delta T cell development


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gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAG2 jagged canonical Notch ligand 2 involved_in IEA Ensembl GO_REF:0000107
G LCK LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:88,719,886...88,745,922
Ensembl chr 6:88,719,881...88,745,914 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308 		JBrowse link
G SOX13 SRY-box transcription factor 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:64,745,762...64,780,942
Ensembl chr 9:64,731,969...64,780,942 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TCF7 transcription factor 7 involved_in ISO (PMID:30413363) UniProt PMID:30413363 NCBI chr 2:136,422,740...136,456,323
Ensembl chr 2:136,422,940...136,457,910 		JBrowse link
CD8-positive, gamma-delta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR9 C-C motif chemokine receptor 9 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:29,033,609...29,051,227
Ensembl chr13:29,033,570...29,054,598 		JBrowse link
G GPR18 G protein-coupled receptor 18 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:68,187,402...68,191,622
Ensembl chr11:68,187,327...68,191,269 		JBrowse link
G LOC100523789 NKG2-A/NKG2-B type II integral membrane protein involved_in ISO (PMID:18064301) UniProt PMID:18064301 NCBI chr 5:61,621,869...61,633,693 JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIMAP5 GTPase, IMAP family member 5 ISO RGD PMID:11859104 RGD:625608 NCBI chr18:6,363,443...6,371,725 JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:88,719,886...88,745,922
Ensembl chr 6:88,719,881...88,745,914 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,825,161...113,944,070 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308 		JBrowse link
G SOX13 SRY-box transcription factor 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:64,745,762...64,780,942
Ensembl chr 9:64,731,969...64,780,942 		JBrowse link
G SOX4 SRY-box transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:16,886,834...16,895,488
Ensembl chr 7:16,891,319...16,892,752 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGR3 early growth response 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:6,943,184...6,948,507
Ensembl chr14:6,944,935...6,948,580 		JBrowse link
G RORC RAR related orphan receptor C acts_upstream_of_or_within ISO (PMID:21737317) MGI PMID:21737317 NCBI chr 4:97,374,672...97,399,017
Ensembl chr 4:97,375,136...97,400,209 		JBrowse link
G SOX13 SRY-box transcription factor 13 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:64,745,762...64,780,942
Ensembl chr 9:64,731,969...64,780,942 		JBrowse link
G TCF7 transcription factor 7 involved_in ISO (PMID:23562159) UniProt PMID:23562159 NCBI chr 2:136,422,740...136,456,323
Ensembl chr 2:136,422,940...136,457,910 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    immune system process 2590
      leukocyte activation 1061
        lymphocyte activation 872
          T cell activation 629
            T cell differentiation 343
              gamma-delta T cell differentiation 17
                gamma-delta T cell differentiation involved in immune response 0
                gamma-delta T cell lineage commitment 0
                gamma-delta intraepithelial T cell differentiation + 3
                negative regulation of gamma-delta T cell differentiation 0
                positive regulation of gamma-delta T cell differentiation 10
                regulation of gamma-delta T cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 18944
    cellular process 18486
      cellular developmental process 4591
        cell differentiation 4590
          cell development 3258
            hemopoiesis 1050
              leukocyte differentiation 677
                mononuclear cell differentiation 550
                  lymphocyte differentiation 455
                    T cell differentiation 343
                      gamma-delta T cell differentiation 17
                        gamma-delta T cell differentiation involved in immune response 0
                        gamma-delta T cell lineage commitment 0
                        gamma-delta intraepithelial T cell differentiation + 3
                        negative regulation of gamma-delta T cell differentiation 0
                        positive regulation of gamma-delta T cell differentiation 10
                        regulation of gamma-delta T cell differentiation + 13
paths to the root