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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-delta T cell differentiation
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Accession:GO:0042492 term browser browse the term
Definition:The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: gamma-delta T lymphocyte differentiation
 related_synonym: gamma-delta T cell development


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gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAG2 jagged canonical Notch ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:105,140,995...105,168,776
Ensembl chr14:105,140,982...105,168,824 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342 		JBrowse link
G SOX13 SRY-box transcription factor 13 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:204,073,115...204,127,743
Ensembl chr 1:204,073,115...204,127,743 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549 		JBrowse link
G TCF7 transcription factor 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr 5:134,108,218...134,148,210
Ensembl chr 5:134,114,681...134,151,865 		JBrowse link
CD8-positive, gamma-delta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR9 C-C motif chemokine receptor 9 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:45,886,064...45,903,174
Ensembl chr 3:45,884,425...45,903,174 		JBrowse link
G GPR18 G protein-coupled receptor 18 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:99,254,739...99,258,379
Ensembl chr13:99,254,732...99,261,744 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IDA (PMID:18064301) UniProt PMID:18064301 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIMAP5 GTPase, IMAP family member 5 ISO RGD PMID:11859104 RGD:625608 NCBI chr 7:150,737,418...150,743,646
Ensembl chr 7:150,722,253...150,750,033 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,244...32,286,165 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342 		JBrowse link
G SOX13 SRY-box transcription factor 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:204,073,115...204,127,743
Ensembl chr 1:204,073,115...204,127,743 		JBrowse link
G SOX4 SRY-box transcription factor 4 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:21,593,751...21,598,619
Ensembl chr 6:21,593,751...21,598,619 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549 		JBrowse link
regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGR3 early growth response 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480 		JBrowse link
G RORC RAR related orphan receptor C acts_upstream_of_or_within ISO (PMID:21737317) MGI PMID:21737317 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G SOX13 SRY-box transcription factor 13 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:204,073,115...204,127,743
Ensembl chr 1:204,073,115...204,127,743 		JBrowse link
G TCF7 transcription factor 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr 5:134,108,218...134,148,210
Ensembl chr 5:134,114,681...134,151,865 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27205
    immune system process 3309
      leukocyte activation 1159
        lymphocyte activation 953
          T cell activation 685
            T cell differentiation 379
              gamma-delta T cell differentiation 17
                gamma-delta T cell differentiation involved in immune response 0
                gamma-delta T cell lineage commitment 0
                gamma-delta intraepithelial T cell differentiation + 3
                negative regulation of gamma-delta T cell differentiation 0
                positive regulation of gamma-delta T cell differentiation 10
                regulation of gamma-delta T cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 27205
    cellular process 19782
      cellular developmental process 5258
        cell differentiation 5257
          cell development 3499
            hemopoiesis 1181
              leukocyte differentiation 755
                mononuclear cell differentiation 621
                  lymphocyte differentiation 511
                    T cell differentiation 379
                      gamma-delta T cell differentiation 17
                        gamma-delta T cell differentiation involved in immune response 0
                        gamma-delta T cell lineage commitment 0
                        gamma-delta intraepithelial T cell differentiation + 3
                        negative regulation of gamma-delta T cell differentiation 0
                        positive regulation of gamma-delta T cell differentiation 10
                        regulation of gamma-delta T cell differentiation + 13
paths to the root