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ONTOLOGY REPORT - ANNOTATIONS


Term:gamma-delta T cell differentiation
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Accession:GO:0042492 term browser browse the term
Definition:The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: gamma-delta T lymphocyte differentiation
 related_synonym: gamma-delta T cell development



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gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag2 jagged canonical Notch ligand 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:1342169|PMID:10383933)
Ensembl
RGD
PMID:10383933 GO_REF:0000107 MGI:1342169 NCBI chr 6:131,983,056...132,005,359
Ensembl chr 6:131,983,056...132,005,818
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of ISO MGI:1857211 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of ISO MGI:2181288 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO (MGI:3695974|PMID:17218525), (MGI:6276541|PMID:30413363) RGD PMID:17218525 PMID:30413363 MGI:3695974 MGI:6276541 NCBI chr13:44,831,097...44,875,522
Ensembl chr13:44,831,085...44,875,762
JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of ISO MGI:103035 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of
involved_in
ISO
IEA
MGI:103036 (MGI:3054293|PMID:15294943)
GO_REF:0000107
RGD
Ensembl
PMID:15294943 GO_REF:0000107 MGI:3054293 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of
involved_in
ISO
IEA
MGI:1857421|MGI:2384078 (MGI:77314|PMID:7477352), (MGI:83585|PMID:8790395)
GO_REF:0000107
RGD
Ensembl
PMID:7477352 PMID:8790395 GO_REF:0000107 MGI:77314 MGI:83585 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (MGI:6276541|PMID:30413363) RGD PMID:30413363 MGI:6276541 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link
CD8-positive, gamma-delta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr9 C-C motif chemokine receptor 9 acts_upstream_of_or_within ISO MGI:3654108 (MGI:5629467|PMID:25348153) RGD PMID:25348153 MGI:5629467 NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969
JBrowse link
G Gpr18 G protein-coupled receptor 18 acts_upstream_of_or_within ISO MGI:5708707 (MGI:5629467|PMID:25348153) RGD PMID:25348153 MGI:5629467 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470
JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:18064301) RGD PMID:18064301 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:11859104 RGD:625608 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:1857211 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5486619|PMID:23562159)
UniProt
RGD
PMID:23562159 GO_REF:0000024 MGI:5486619 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934
Ensembl chr 7:134,577,482...134,622,934
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (MGI:70338|PMID:7807014) RGD PMID:7807014 MGI:70338 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO (MGI:5486619|PMID:23562159) RGD PMID:23562159 MGI:5486619 NCBI chr13:44,831,097...44,875,522
Ensembl chr13:44,831,085...44,875,762
JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (MGI:5486619|PMID:23562159) RGD PMID:23562159 MGI:5486619 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665
JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:3054293|PMID:15294943) RGD PMID:15294943 MGI:3054293 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (MGI:3054293|PMID:15294943)
Ensembl
RGD
PMID:15294943 GO_REF:0000107 MGI:3054293 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857421|MGI:2384078 (MGI:77314|PMID:7477352), (MGI:83585|PMID:8790395)
Ensembl
RGD
PMID:7477352 PMID:8790395 GO_REF:0000107 MGI:77314 MGI:83585 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr3 early growth response 3 acts_upstream_of_or_within ISO (MGI:5139961|PMID:21737317) RGD PMID:21737317 MGI:5139961 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within ISO (MGI:5139961|PMID:21737317) RGD PMID:21737317 MGI:5139961 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Sox13 SRY-box transcription factor 13 acts_upstream_of_or_within ISO (MGI:5139961|PMID:21737317) RGD PMID:21737317 MGI:5139961 NCBI chr13:44,831,097...44,875,522
Ensembl chr13:44,831,085...44,875,762
JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (MGI:5486619|PMID:23562159) RGD PMID:23562159 MGI:5486619 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      leukocyte activation 1025
        lymphocyte activation 840
          T cell activation 556
            T cell differentiation 306
              gamma-delta T cell differentiation 17
                gamma-delta T cell differentiation involved in immune response 0
                gamma-delta T cell lineage commitment 0
                gamma-delta intraepithelial T cell differentiation + 3
                negative regulation of gamma-delta T cell differentiation 0
                positive regulation of gamma-delta T cell differentiation 10
                regulation of gamma-delta T cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            immune system development 1129
              hematopoietic or lymphoid organ development 1061
                hemopoiesis 1012
                  leukocyte differentiation 634
                    mononuclear cell differentiation 485
                      lymphocyte differentiation 426
                        T cell differentiation 306
                          gamma-delta T cell differentiation 17
                            gamma-delta T cell differentiation involved in immune response 0
                            gamma-delta T cell lineage commitment 0
                            gamma-delta intraepithelial T cell differentiation + 3
                            negative regulation of gamma-delta T cell differentiation 0
                            positive regulation of gamma-delta T cell differentiation 10
                            regulation of gamma-delta T cell differentiation + 13
paths to the root