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ONTOLOGY REPORT - ANNOTATIONS

Term:inner ear auditory receptor cell differentiation
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Accession:GO:0042491 term browser browse the term
Definition:The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.
Comment:Note that this term refers to the mechanosensory hair cells of the inner ear.
Synonyms:exact_synonym: auditory hair cell differentiation
 related_synonym: auditory receptor cell differentiation


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inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOH1 atonal bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:16,807,217...16,809,294
Ensembl chr32:16,807,336...16,808,406 		JBrowse link
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G CDH23 cadherin related 23 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:22,206,972...22,570,875
Ensembl chr 4:22,207,001...22,571,131 		JBrowse link
G CLRN2 clarin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:62,958,242...62,967,878
Ensembl chr 3:62,959,224...62,967,994 		JBrowse link
G CUX1 cut like homeobox 1 acts_upstream_of_or_within ISO (PMID:11544187) MGI PMID:11544187 NCBI chr 6:7,820,154...8,108,236
Ensembl chr 6:7,820,764...8,195,631 		JBrowse link
G FGF20 fibroblast growth factor 20 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:40,330,793...40,339,925
Ensembl chr16:40,331,307...40,339,616 		JBrowse link
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 3:33,663,414...33,746,120
Ensembl chr 3:33,664,169...33,744,328 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 4:49,342,527...49,579,697
Ensembl chr 4:49,342,508...49,578,092 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 3:33,878,948...34,101,987
Ensembl chr 3:33,878,904...34,097,764 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:12441305) MGI PMID:12441305 NCBI chr 6:56,473,032...56,484,422
Ensembl chr 6:56,256,305...56,484,422 		JBrowse link
G GRXCR1 glutaredoxin and cysteine rich domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:39,766,910...39,882,076
Ensembl chr13:39,766,919...39,882,086 		JBrowse link
G GSDME gasdermin E acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:38,210,975...38,286,729
Ensembl chr14:38,211,540...38,292,280 		JBrowse link
G HES1 hes family bHLH transcription factor 1 acts_upstream_of IEA Ensembl GO_REF:0000107
G HES5 hes family bHLH transcription factor 5 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 5:57,387,961...57,389,412
Ensembl chr 5:57,388,674...57,389,388 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 acts_upstream_of_or_within ISO
IEA 		RGD
Ensembl		 PMID:10887092 GO_REF:0000107 RGD:1582345 NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199 		JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 involved_in
acts_upstream_of_or_within 		ISA
ISO 		(PMID:8973172)
(PMID:15328414), (PMID:17074442) 		AgBase
MGI		 PMID:8973172 PMID:15328414 PMID:17074442 NCBI chr 4:26,844,250...27,338,271
Ensembl chr 4:26,844,250...27,555,776 		JBrowse link
G MCOLN2 mucolipin TRP cation channel 2 acts_upstream_of_or_within ISO (PMID:12403827) MGI PMID:12403827 NCBI chr 6:62,956,797...63,008,527
Ensembl chr 6:62,956,804...63,200,612 		JBrowse link
G MCOLN3 mucolipin TRP cation channel 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:62,923,598...62,953,696
Ensembl chr 6:62,923,267...62,953,564 		JBrowse link
G MINAR2 membrane integral NOTCH2 associated receptor 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:18,506,042...18,531,187
Ensembl chr11:18,507,059...18,524,589 		JBrowse link
G MYO6 myosin VI acts_upstream_of_or_within
involved_in 		ISO
IBA 		(PMID:10525338), (PMID:5980120), (PMID:7493015) MGI
GO_Central		 PMID:5980120 PMID:7493015 PMID:10525338 GO_REF:0000033 NCBI chr12:37,359,200...37,502,342
Ensembl chr12:37,413,570...37,500,724 		JBrowse link
G MYO7A myosin VIIA acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:21,539,735...21,624,063
Ensembl chr21:21,539,785...21,624,279 		JBrowse link
G PCDH15 protocadherin related 15 acts_upstream_of_or_within ISO (PMID:16481439) MGI PMID:16481439 NCBI chr26:33,426,728...34,589,208
Ensembl chr26:33,719,839...34,588,017 		JBrowse link
G PLS3 plastin 3 ISO RGD PMID:12378542 RGD:731234 NCBI chr  X:88,308,817...88,399,682
Ensembl chr  X:88,308,888...88,398,810 		JBrowse link
G POU4F3 POU class 4 homeobox 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:40,762,499...40,764,131
Ensembl chr 2:40,762,477...40,765,161 		JBrowse link
G USH1C USH1 protein network component harmonin acts_upstream_of_or_within ISO (PMID:14519688) MGI PMID:14519688 NCBI chr21:40,055,786...40,100,685
Ensembl chr21:40,055,730...40,101,430 		JBrowse link
G USH2A usherin acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr38:11,063,221...11,750,444
Ensembl chr38:11,063,817...11,750,444 		JBrowse link
auditory receptor cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLRN1 clarin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:45,512,639...45,551,010
Ensembl chr23:45,513,416...45,551,178 		JBrowse link
G ELMOD3 ELMO domain containing 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:39,642,101...39,668,079
Ensembl chr17:39,643,676...39,665,726 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,554,390...46,830,533
Ensembl chr18:46,518,908...46,830,043 		JBrowse link
G LOC106560171 transmembrane O-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:25,975,547...25,981,097 JBrowse link
G LOC477647 ALG10 alpha-1,2-glucosyltransferase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:15,121,327...15,127,229 JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:46,648,057...46,731,259
Ensembl chr 9:46,648,052...46,771,400 		JBrowse link
G PDZD7 PDZ domain containing 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr28:13,693,032...13,711,654
Ensembl chr28:13,693,023...13,711,784 		JBrowse link
G SLC4A7 solute carrier family 4 member 7 acts_upstream_of_or_within
involved_in 		ISO
IBA 		(PMID:12808454) MGI
GO_Central		 PMID:12808454 GO_REF:0000033 NCBI chr23:16,710,649...16,788,277
Ensembl chr23:16,710,701...16,785,541 		JBrowse link
G TMC1 transmembrane channel like 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:85,041,039...85,159,607
Ensembl chr 1:85,041,574...85,187,369 		JBrowse link
auditory receptor cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAG2 jagged canonical Notch ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,535,539...72,553,531
Ensembl chr 8:72,535,107...72,550,322 		JBrowse link
G NOTCH1 notch receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:84,060,417...84,286,008
Ensembl chr 3:84,064,440...84,286,360 		JBrowse link
auditory receptor cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOH1 atonal bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:16,807,217...16,809,294
Ensembl chr32:16,807,336...16,808,406 		JBrowse link
auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOH1 atonal bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:16,807,217...16,809,294
Ensembl chr32:16,807,336...16,808,406 		JBrowse link
auditory receptor cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR96 microRNA mir-96 acts_upstream_of_or_within ISO (PMID:19363478) MGI PMID:19363478 NCBI chr14:7,068,754...7,068,842
Ensembl chr14:7,068,754...7,068,842 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:20016102) MGI PMID:20016102 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216 		JBrowse link
G SCRIB scribble planar cell polarity protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:37,356,405...37,374,765
Ensembl chr13:37,356,405...37,374,681 		JBrowse link
G SEC24B SEC24 homolog B, COPII coat complex component acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:29,671,702...29,766,628
Ensembl chr32:29,671,738...29,772,192 		JBrowse link
G SLITRK6 SLIT and NTRK like family member 6 acts_upstream_of_or_within ISO (PMID:19936227) MGI PMID:19936227 NCBI chr22:37,911,533...37,918,273
Ensembl chr22:37,912,612...37,925,177 		JBrowse link
G USH1C USH1 protein network component harmonin involved_in IBA GO_Central GO_REF:0000033 NCBI chr21:40,055,786...40,100,685
Ensembl chr21:40,055,730...40,101,430 		JBrowse link
G WDPCP WD repeat containing planar cell polarity effector acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:62,894,818...63,316,555
Ensembl chr10:62,877,527...63,316,345 		JBrowse link
auditory receptor cell stereocilium organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD24 ankyrin repeat domain 24 involved_in ISO (PMID:35175278) UniProt PMID:35175278 NCBI chr20:55,391,381...55,404,538
Ensembl chr20:55,391,652...55,404,544 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:11875276) MGI PMID:11875276 NCBI chr20:7,665,468...8,037,407
Ensembl chr20:7,749,807...8,034,474 		JBrowse link
G CDH23 cadherin related 23 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:22,206,972...22,570,875
Ensembl chr 4:22,207,001...22,571,131 		JBrowse link
G CLIC5 chloride intracellular channel 5 acts_upstream_of_or_within ISO (PMID:17021174) MGI PMID:17021174 NCBI chr12:14,160,524...14,318,174
Ensembl chr12:14,144,390...14,318,582 		JBrowse link
G CLRN1 clarin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:45,512,639...45,551,010
Ensembl chr23:45,513,416...45,551,178 		JBrowse link
G CLRN2 clarin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:62,958,242...62,967,878
Ensembl chr 3:62,959,224...62,967,994 		JBrowse link
G GRXCR1 glutaredoxin and cysteine rich domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:39,766,910...39,882,076
Ensembl chr13:39,766,919...39,882,086 		JBrowse link
G GRXCR2 glutaredoxin and cysteine rich domain containing 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:40,310,285...40,330,200
Ensembl chr 2:40,315,807...40,328,240 		JBrowse link
G LHFPL5 LHFPL tetraspan subfamily member 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:4,919,732...4,936,823
Ensembl chr12:4,902,832...4,936,413 		JBrowse link
G MYO3A myosin IIIA involved_in ISO (PMID:26754646) MGI PMID:26754646 NCBI chr 2:7,455,125...7,695,483
Ensembl chr 2:7,455,625...7,696,043 		JBrowse link
G MYO3B myosin IIIB involved_in ISO (PMID:26754646) MGI PMID:26754646 NCBI chr36:14,804,662...15,229,597
Ensembl chr36:14,803,514...15,209,820 		JBrowse link
G MYO7A myosin VIIA acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:21,539,735...21,624,063
Ensembl chr21:21,539,785...21,624,279 		JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:5,661,792...5,679,783
Ensembl chr 9:5,662,464...5,679,570 		JBrowse link
G PCDH15 protocadherin related 15 acts_upstream_of_or_within ISO (PMID:16887306)
(PMID:10978835)
(PMID:11124469)
(PMID:15537665)
(PMID:23217710) 		MGI PMID:10978835 PMID:11124469 PMID:15537665 PMID:16887306 PMID:23217710 NCBI chr26:33,426,728...34,589,208
Ensembl chr26:33,719,839...34,588,017 		JBrowse link
G PDZD7 PDZ domain containing 7 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr28:13,693,032...13,711,654
Ensembl chr28:13,693,023...13,711,784 		JBrowse link
G PLS1 plastin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:38,243,631...38,347,195
Ensembl chr23:38,243,024...38,347,202 		JBrowse link
G REST RE1 silencing transcription factor involved_in ISO (PMID:29961578) UniProt PMID:29961578 NCBI chr13:49,041,082...49,062,596
Ensembl chr13:49,041,047...49,059,388 		JBrowse link
G RIPOR2 RHO family interacting cell polarization regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:22,823,053...23,041,765
Ensembl chr35:22,824,106...23,041,743 		JBrowse link
G SCRIB scribble planar cell polarity protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:37,356,405...37,374,765
Ensembl chr13:37,356,405...37,374,681 		JBrowse link
G SEC24B SEC24 homolog B, COPII coat complex component acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:29,671,702...29,766,628
Ensembl chr32:29,671,738...29,772,192 		JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:10464373), (PMID:10466888) MGI PMID:10464373 PMID:10466888 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G STRC stereocilin acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:21165971) Ensembl
UniProt		 PMID:21165971 GO_REF:0000107 NCBI chr30:10,444,726...10,459,058
Ensembl chr30:10,444,793...10,460,785 		JBrowse link
G TECTA tectorin alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:12,879,963...12,949,211
Ensembl chr 5:12,879,951...12,949,147 		JBrowse link
G TPRN taperin involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107
G TRIOBP TRIO and F-actin binding protein acts_upstream_of_or_within ISO (PMID:20510926) MGI PMID:20510926 NCBI chr10:26,856,981...26,913,330
Ensembl chr10:26,857,678...26,911,083 		JBrowse link
G WHRN whirlin involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr11:68,617,383...68,699,824
Ensembl chr11:68,617,377...68,699,977 		JBrowse link
negative regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLL1 delta like canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:16495313) MGI PMID:16495313 NCBI chr12:72,265,078...72,272,347
Ensembl chr12:72,265,682...72,272,348 		JBrowse link
G HES1 hes family bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107
G HES5 hes family bHLH transcription factor 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:57,387,961...57,389,412
Ensembl chr 5:57,388,674...57,389,388 		JBrowse link
G NOTCH1 notch receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
positive regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOH1 atonal bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:16,807,217...16,809,294
Ensembl chr32:16,807,336...16,808,406 		JBrowse link
regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:21300049) MGI PMID:21300049 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:64,630,656...64,646,546 JBrowse link
G MYCL MYCL proto-oncogene, bHLH transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:2,975,757...3,019,313
Ensembl chr15:3,006,409...3,013,381 		JBrowse link
G MYCN MYCN proto-oncogene, bHLH transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:11,720,857...11,724,308 JBrowse link
G NOTCH1 notch receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESRP1 epithelial splicing regulatory protein 1 involved_in ISO (PMID:29107558) UniProt PMID:29107558 NCBI chr29:39,322,516...39,388,363
Ensembl chr29:39,333,117...39,387,337 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22280
    developmental process 7097
      anatomical structure development 6626
        inner ear development 254
          inner ear receptor cell differentiation 95
            inner ear auditory receptor cell differentiation 68
              auditory receptor cell development + 39
              auditory receptor cell fate commitment + 5
              negative regulation of inner ear auditory receptor cell differentiation + 4
              positive regulation of inner ear auditory receptor cell differentiation 1
              regulation of inner ear auditory receptor cell differentiation + 10
Path 2
Term Annotations click to browse term
  biological_process 22280
    developmental process 7097
      anatomical structure development 6626
        multicellular organism development 5343
          system development 4662
            nervous system development 2912
              neurogenesis 2140
                generation of neurons 1834
                  neuron differentiation 1757
                    mechanoreceptor differentiation 102
                      inner ear receptor cell differentiation 95
                        inner ear auditory receptor cell differentiation 68
                          auditory receptor cell development + 39
                          auditory receptor cell fate commitment + 5
                          negative regulation of inner ear auditory receptor cell differentiation + 4
                          positive regulation of inner ear auditory receptor cell differentiation 1
                          regulation of inner ear auditory receptor cell differentiation + 10
paths to the root