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ONTOLOGY REPORT - ANNOTATIONS

Term:inner ear auditory receptor cell differentiation
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Accession:GO:0042491 term browser browse the term
Definition:The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell.
Comment:Note that this term refers to the mechanosensory hair cells of the inner ear.
Synonyms:exact_synonym: auditory hair cell differentiation
 related_synonym: auditory receptor cell differentiation


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inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:15543141)
(PMID:11973280) 		MGI PMID:11973280 PMID:15543141 NCBI chr 6:77,939,477...77,941,402 JBrowse link
G Clrn2 clarin 2 acts_upstream_of_or_within ISO (PMID:31448880) MGI PMID:31448880 NCBI chr11:60,417,154...60,425,513 JBrowse link
G Cux1 cut like homeobox 1 acts_upstream_of_or_within ISO (PMID:11544187) MGI PMID:11544187 NCBI chr16:17,449,881...17,770,317 JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha5 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 2:141,775,468...141,890,756 JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta2 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 9:25,286,309...25,493,196 JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta3 acts_upstream_of_or_within ISO (PMID:17021187) MGI PMID:17021187 NCBI chr 2:141,460,704...141,696,691 JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:12441305) MGI PMID:12441305 NCBI chr11:17,485,285...17,498,525 JBrowse link
G Grxcr1 glutaredoxin and cysteine rich domain containing 1 acts_upstream_of_or_within ISO (PMID:12405956) MGI PMID:12405956 NCBI chr11:25,141,949...25,263,957 JBrowse link
G Jag1 jagged canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:16495313) MGI
RGD		 PMID:10887092 PMID:16495313 RGD:1582345 NCBI chr 5:116,665,740...116,701,378 JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 acts_upstream_of_or_within ISO (PMID:15328414), (PMID:17074442) MGI PMID:15328414 PMID:17074442 NCBI chr12:93,034,529...93,729,512 JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 acts_upstream_of_or_within ISO (PMID:12403827) MGI PMID:12403827 NCBI chr 3:14,762,626...14,797,548 JBrowse link
G Minar2 membrane integral NOTCH2 associated receptor 2 acts_upstream_of_or_within ISO (PMID:35727972) MGI PMID:35727972 NCBI chr15:72,762,671...72,776,480 JBrowse link
G Myo6 myosin VI acts_upstream_of_or_within ISO (PMID:10525338), (PMID:5980120), (PMID:7493015) MGI PMID:5980120 PMID:7493015 PMID:10525338 NCBI chr 8:74,395,096...74,537,284 JBrowse link
G Myo7a myosin VIIA acts_upstream_of_or_within ISO (PMID:15389316)
(PMID:12121736)
(PMID:11753415) 		MGI PMID:11753415 PMID:12121736 PMID:15389316 NCBI chr 2:96,333,552...96,402,681 JBrowse link
G Pcdh15 protocadherin related 15 acts_upstream_of_or_within ISO (PMID:16481439) MGI PMID:16481439 NCBI chr18:12,767,430...12,874,758 JBrowse link
G Pls3 plastin 3 ISO RGD PMID:12378542 RGD:731234 NCBI chr  X:101,314,037...101,402,273 JBrowse link
G Pou4f3 POU class 4 homeobox 3 acts_upstream_of_or_within ISO (PMID:8637595)
(PMID:12585968) 		MGI PMID:8637595 PMID:12585968 NCBI chr15:3,567,074...3,569,657 JBrowse link
G Ush1c USH1 protein network component harmonin acts_upstream_of_or_within ISO (PMID:14519688) MGI PMID:14519688 NCBI chr 2:153,261,489...153,309,693 JBrowse link
auditory receptor cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clrn1 clarin 1 acts_upstream_of_or_within ISO (PMID:19414487) MGI PMID:19414487 NCBI chr 3:196,400,333...196,423,538 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:15630379) MGI PMID:15630379 NCBI chr13:60,918,566...60,973,142 JBrowse link
G Pafah1b1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 involved_in ISO (PMID:23533177) CACAO PMID:23533177 NCBI chr 9:93,406,083...93,464,249 JBrowse link
G Pdzd7 PDZ domain containing 7 acts_upstream_of_or_within ISO (PMID:24334608) MGI PMID:24334608 NCBI chr 2:44,533,095...44,552,284 JBrowse link
G Slc4a7 solute carrier family 4 member 7 acts_upstream_of_or_within ISO (PMID:12808454) MGI PMID:12808454 NCBI chr12:84,672,405...84,751,781 JBrowse link
G Tmc1 transmembrane channel like 1 acts_upstream_of_or_within ISO (PMID:22105175) MGI PMID:22105175 NCBI chr 2:20,883,240...21,046,161 JBrowse link
auditory receptor cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag2 jagged canonical Notch ligand 2 involved_in ISO (PMID:10080181) UniProt PMID:10080181 NCBI chr 7:130,506,433...130,528,632 JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (PMID:19154718) MGI PMID:19154718 NCBI chr 5:10,588,654...10,634,419 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO (PMID:19154718) MGI PMID:19154718 NCBI chr11:52,493,689...52,556,515 JBrowse link
auditory receptor cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:16407553) MGI PMID:16407553 NCBI chr 6:77,939,477...77,941,402 JBrowse link
auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:10364557) MGI PMID:10364557 NCBI chr 6:77,939,477...77,941,402 JBrowse link
auditory receptor cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:20016102) MGI PMID:20016102 NCBI chr16:9,622,793...9,644,543 JBrowse link
G Scrib scribble planar cell polarity protein acts_upstream_of_or_within ISO (PMID:20215345) MGI PMID:20215345 NCBI chr 1:248,364,681...248,387,637 JBrowse link
G Sec24b SEC24 homolog B, COPII component acts_upstream_of_or_within ISO (PMID:20215345) MGI PMID:20215345 NCBI chr 3:29,242,452...29,312,013 JBrowse link
G Slitrk6 SLIT and NTRK like family member 6 acts_upstream_of_or_within ISO (PMID:19936227) MGI PMID:19936227 NCBI chr12:14,525,927...14,529,654 JBrowse link
G Wdpcp WD repeat containing planar cell polarity effector acts_upstream_of_or_within ISO (PMID:24302887) MGI PMID:24302887 NCBI chr11:94,890,263...95,116,173 JBrowse link
auditory receptor cell stereocilium organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd24 ankyrin repeat domain 24 involved_in ISO (PMID:35175278) UniProt PMID:35175278 NCBI chr 1:153,241,983...153,260,609 JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:11875276) MGI PMID:11875276 NCBI chr 6:32,479,315...32,789,906 JBrowse link
G Clic5 chloride intracellular channel 5 acts_upstream_of_or_within ISO (PMID:17021174) MGI PMID:17021174 NCBI chr 4:85,592,234...85,687,481 JBrowse link
G Clrn1 clarin 1 acts_upstream_of_or_within ISO (PMID:19414487), (PMID:19423712) MGI PMID:19414487 PMID:19423712 NCBI chr 3:196,400,333...196,423,538 JBrowse link
G Clrn2 clarin 2 involved_in ISO (PMID:33496845) UniProt PMID:33496845 NCBI chr11:60,417,154...60,425,513 JBrowse link
G Grxcr1 glutaredoxin and cysteine rich domain containing 1 acts_upstream_of_or_within ISO (PMID:35235570) MGI PMID:35235570 NCBI chr11:25,141,949...25,263,957 JBrowse link
G Grxcr2 glutaredoxin and cysteine rich domain containing 2 acts_upstream_of_or_within ISO (PMID:30380417) MGI PMID:30380417 NCBI chr15:3,164,544...3,178,080 JBrowse link
G Lhfpl5 LHFPL tetraspan subfamily member 5 acts_upstream_of_or_within ISO (PMID:15905332)
(PMID:17876667), (PMID:23217710) 		MGI PMID:15905332 PMID:17876667 PMID:23217710 NCBI chr18:5,281,882...5,288,971 JBrowse link
G Myo3a myosin IIIA involved_in ISO (PMID:26754646) MGI PMID:26754646 NCBI chr14:1,939,394...2,125,796 JBrowse link
G Myo3b myosin IIIB involved_in ISO (PMID:26754646) MGI PMID:26754646 NCBI chr 5:47,397,652...47,745,863 JBrowse link
G Myo7a myosin VIIA acts_upstream_of_or_within ISO (PMID:12121736)
(PMID:11753415)
(PMID:17050716) 		MGI PMID:11753415 PMID:12121736 PMID:17050716 NCBI chr 2:96,333,552...96,402,681 JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 acts_upstream_of_or_within ISO (PMID:24920589) MGI PMID:24920589 NCBI chr 9:68,921,622...68,939,130 JBrowse link
G Pcdh15 protocadherin related 15 acts_upstream_of_or_within ISO (PMID:15537665)
(PMID:11124469)
(PMID:23217710)
(PMID:16887306)
(PMID:10978835) 		MGI PMID:10978835 PMID:11124469 PMID:15537665 PMID:16887306 PMID:23217710 NCBI chr18:12,767,430...12,874,758 JBrowse link
G Pdzd7 PDZ domain containing 7 acts_upstream_of_or_within ISO (PMID:24334608) MGI PMID:24334608 NCBI chr 2:44,533,095...44,552,284 JBrowse link
G Pls1 plastin 1 involved_in ISO (PMID:25124451) UniProt PMID:25124451 NCBI chr 8:87,208,916...87,301,542 JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:29961578) UniProt PMID:29961578 NCBI chr11:34,025,892...34,046,092 JBrowse link
G Ripor2 RHO family interacting cell polarization regulator 2 involved_in ISO (PMID:27269051) UniProt PMID:27269051 NCBI chr14:43,700,304...43,789,743 JBrowse link
G Scrib scribble planar cell polarity protein acts_upstream_of_or_within ISO (PMID:20215345) MGI PMID:20215345 NCBI chr 1:248,364,681...248,387,637 JBrowse link
G Sec24b SEC24 homolog B, COPII component acts_upstream_of_or_within ISO (PMID:20215345) MGI PMID:20215345 NCBI chr 3:29,242,452...29,312,013 JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:10464373), (PMID:10466888) MGI PMID:10464373 PMID:10466888 NCBI chr 4:54,366,632...54,372,166 JBrowse link
G Strc stereocilin acts_upstream_of_or_within
involved_in 		ISO (PMID:30801007)
(PMID:21165971)
(PMID:18849963) 		MGI
UniProt		 PMID:18849963 PMID:21165971 PMID:30801007 NCBI chr 5:99,515,352...99,532,934 JBrowse link
G Tprn taperin acts_upstream_of_or_within ISO (PMID:30380417) MGI PMID:30380417 NCBI chr 5:11,914,023...11,922,173 JBrowse link
G Whrn whirlin acts_upstream_of_or_within ISO (PMID:27117407) MGI PMID:27117407 NCBI chr 1:90,089,102...90,172,093 JBrowse link
negative regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:16495313) MGI PMID:16495313 NCBI chr14:632,774...640,362 JBrowse link
G Hes1 hes family bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:11023859), (PMID:11425898)
(PMID:21300049) 		MGI PMID:11023859 PMID:11425898 PMID:21300049 NCBI chr 4:14,946,704...14,949,676 JBrowse link
G Hes5 hes family bHLH transcription factor 5 acts_upstream_of_or_within ISO (PMID:11425898)
(PMID:21300049) 		MGI PMID:11425898 PMID:21300049 NCBI chr 1:5,758,049...5,759,476 JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (PMID:25535395) MGI PMID:25535395 NCBI chr 5:10,588,654...10,634,419 JBrowse link
positive regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:11023859), (PMID:19154718) MGI PMID:11023859 PMID:19154718 NCBI chr 6:77,939,477...77,941,402 JBrowse link
regulation of inner ear auditory receptor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:21300049) MGI PMID:21300049 NCBI chr 3:142,817,894...142,821,577 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (PMID:19154718) MGI PMID:19154718 NCBI chr 2:204,883,044...204,893,463 JBrowse link
G Mycl MYCL proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO (PMID:23022312) MGI PMID:23022312 NCBI chr 1:35,253,503...35,260,353 JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO (PMID:23022312) MGI PMID:23022312 NCBI chr 7:32,885,579...32,891,417 JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (PMID:25535395) MGI PMID:25535395 NCBI chr 5:10,588,654...10,634,419 JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISO (PMID:29107558) UniProt PMID:29107558 NCBI chr 1:132,317,296...132,370,873 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12423
    developmental process 5881
      anatomical structure development 5547
        inner ear development 230
          inner ear receptor cell differentiation 83
            inner ear auditory receptor cell differentiation 55
              auditory receptor cell development + 30
              auditory receptor cell fate commitment + 5
              negative regulation of inner ear auditory receptor cell differentiation + 4
              positive regulation of inner ear auditory receptor cell differentiation 1
              regulation of inner ear auditory receptor cell differentiation + 10
Path 2
Term Annotations click to browse term
  biological_process 12423
    developmental process 5881
      anatomical structure development 5547
        multicellular organism development 4531
          system development 3963
            nervous system development 2463
              neurogenesis 1824
                generation of neurons 1572
                  neuron differentiation 1500
                    mechanoreceptor differentiation 89
                      inner ear receptor cell differentiation 83
                        inner ear auditory receptor cell differentiation 55
                          auditory receptor cell development + 30
                          auditory receptor cell fate commitment + 5
                          negative regulation of inner ear auditory receptor cell differentiation + 4
                          positive regulation of inner ear auditory receptor cell differentiation 1
                          regulation of inner ear auditory receptor cell differentiation + 10
paths to the root