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ONTOLOGY REPORT - ANNOTATIONS


Term:pigment metabolic process
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Accession:GO:0042440 term browser browse the term
Definition:The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
Synonyms:exact_synonym: pigment metabolism



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carotenoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPOX protoporphyrinogen oxidase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
eye pigment biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR143 G protein-coupled receptor 143 involved_in TAS (PMID:7647783) PINC PMID:7647783 NCBI chr  X:9,725,346...9,778,602
Ensembl chr  X:9,725,346...9,786,297
JBrowse link
G TYR tyrosinase involved_in TAS (PMID:7704033) PINC PMID:7704033 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
flavone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha ISO hesperetin RGD PMID:22767158 RGD:7242166 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 involved_in IDA (PMID:18052087) BHF-UCL PMID:18052087 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 involved_in IDA (PMID:18052087) BHF-UCL PMID:18052087 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 involved_in IC (PMID:18052087) BHF-UCL PMID:18052087 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 involved_in IDA (PMID:18052087) BHF-UCL PMID:18052087 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 involved_in IDA (PMID:18052087) BHF-UCL PMID:18052087 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
flavonol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGDS TDP-glucose 4,6-dehydratase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:94,574,054...94,596,273
Ensembl chr13:94,574,054...94,596,242
JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL133353.2 novel transcript involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 Ensembl chr10:99,651,595...99,732,112 JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
IMP
(PMID:16782876)
(PMID:16103131)
(PMID:12928484)
Ensembl
MGI
GO_Central
TreeGrafter
HGNC-UCL
PMID:12928484 PMID:16103131 PMID:16782876 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736
JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in IEA
IBA
IGI
(PMID:12474143) UniProt
GO_Central
TreeGrafter
InterPro
HGNC-UCL
PMID:12474143 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127
JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648
JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732
JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288
JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) NOT|involved_in IMP (PMID:22655043) UniProt PMID:22655043 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994
JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648
JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732
JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288
JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:229,516,582...229,558,707
Ensembl chr 1:229,516,582...229,558,707
JBrowse link
G ALAD aminolevulinate dehydratase acts_upstream_of_or_within
involved_in
ISO
IBA
IEA
IDA
TAS
(PMID:14050799), (PMID:4959158), (PMID:4981581)
(PMID:11032836)
(PMID:3758678)
RGD
MGI
GO_Central
TreeGrafter
UniProt
Ensembl
PINC
PMID:1764448 PMID:3758678 PMID:4959158 PMID:4981581 PMID:11032836 More... GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:1599020 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in TAS
IEA
IBA
(PMID:2347585) PINC
TreeGrafter
GO_Central
UniProt
PMID:2347585 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in ISS
IEA
IBA
NAS
(PMID:14643893) UniProt
TreeGrafter
GO_Central
Ensembl
PMID:14643893 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA
IBA
IMP
(PMID:23135403) Ensembl
GO_Central
UniProt
PMID:23135403 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:28,236,124...28,238,100
Ensembl chr 1:28,236,109...28,246,906
JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA
TAS
UniProt
InterPro
Reactome
GO_REF:0000002 GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736
JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 involved_in TAS
IEA
Reactome
UniProt
GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127
JBrowse link
G CPOX coproporphyrinogen oxidase acts_upstream_of_or_within
involved_in
ISO
IEA
TAS
(PMID:8407975)
(PMID:8159699)
RGD
MGI
Ensembl
UniProt
PINC
PMID:3955059 PMID:8159699 PMID:8407975 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117 RGD:1600961 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648
JBrowse link
G FECH ferrochelatase acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
TAS
IDA
(PMID:9989256)
(PMID:8611576)
(PMID:15496139), (PMID:16503645)
(PMID:16306232)
(PMID:1729699)
(PMID:27599036)
RGD
MGI
TreeGrafter
GO_Central
Ensembl
PINC
UniProt
InterPro
PMID:1729699 PMID:3955059 PMID:8611576 PMID:9989256 PMID:15496139 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1600961 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732
JBrowse link
G FLVCR1 FLVCR choline and heme transporter 1 involved_in TAS Reactome Reactome:R-HSA-189451 NCBI chr 1:212,858,275...212,899,363
Ensembl chr 1:212,858,275...212,899,363
JBrowse link
G FXN frataxin involved_in NAS
IEA
(PMID:15123683) BHF-UCL
UniProt
PMID:15123683 GO_REF:0000043 NCBI chr 9:69,035,752...69,079,076
Ensembl chr 9:69,035,751...69,079,076
JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IDA
IEA
IBA
IC
(PMID:18936296)
(PMID:18004775)
UniProt
TreeGrafter
GO_Central
PMID:18004775 PMID:18936296 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G HNF1A HNF1 homeobox A involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10617683) Ensembl
MGI
PMID:10617683 GO_REF:0000107 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512
JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:228,165,804...228,182,257
Ensembl chr 1:228,165,804...228,182,257
JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 involved_in TAS (PMID:9501099) PINC PMID:9501099 NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545
JBrowse link
G PGRMC1 progesterone receptor membrane component 1 involved_in IDA (PMID:27599036) UniProt PMID:27599036 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466
JBrowse link
G PPOX protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in
ISO
IBA
IDA
IEA
(PMID:3346226)
(PMID:7713909)
RGD
MGI
GO_Central
UniProt
Ensembl
PMID:3346226 PMID:3955059 PMID:7713909 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 RGD:1600961 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
G SLC11A2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11739192) Ensembl
MGI
PMID:11739192 GO_REF:0000107 NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566
JBrowse link
G SLC25A38 solute carrier family 25 member 38 involved_in TAS (PMID:19412178) UniProt PMID:19412178 NCBI chr 3:39,383,370...39,397,351
Ensembl chr 3:39,383,370...39,397,351
JBrowse link
G SLC25A39 solute carrier family 25 member 39 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:44,319,628...44,324,823
Ensembl chr17:44,319,625...44,324,870
JBrowse link
G SRRD SRR1 domain containing involved_in IEA UniProt GO_REF:0000043 NCBI chr22:26,483,877...26,494,658
Ensembl chr22:26,483,877...26,494,658
JBrowse link
G TMEM14C transmembrane protein 14C involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:10,723,070...10,731,127
Ensembl chr 6:10,722,915...10,731,129
JBrowse link
G TSPO translocator protein involved_in TAS (PMID:16822554) HGNC-UCL PMID:16822554 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
IC
(PMID:17360334)
(PMID:18004775)
Ensembl
MGI
GO_Central
UniProt
PMID:17360334 PMID:18004775 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
G UROS uroporphyrinogen III synthase involved_in IDA
IEA
TAS
IC
(PMID:3805019)
(PMID:18004775)
UniProt
Reactome
PMID:3805019 PMID:18004775 GO_REF:0000043 Reactome:R-HSA-189451 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288
JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor involved_in NAS (PMID:11877257) UniProt PMID:11877257 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328
JBrowse link
G BLVRA biliverdin reductase A involved_in IEA
IDA
(PMID:10858451) InterPro
UniProt
PMID:10858451 GO_REF:0000002 GO_REF:0000104 NCBI chr 7:43,758,122...43,807,342
Ensembl chr 7:43,758,680...43,807,342
JBrowse link
G BLVRB biliverdin reductase B involved_in IDA (PMID:10858451), (PMID:7929092) UniProt PMID:7929092 PMID:10858451 NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764
JBrowse link
G HMOX1 heme oxygenase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
IDA
(PMID:31571584)
(PMID:17915953)
RGD
MGI
TreeGrafter
Ensembl
GO_Central
BHF-UCL
PMID:15226268 PMID:17915953 PMID:31571584 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1547877 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HMOX2 heme oxygenase 2 involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr16:4,474,736...4,510,347
Ensembl chr16:4,474,690...4,510,347
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 involved_in TAS Reactome Reactome:R-HSA-189483 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300
JBrowse link
heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in IDA (PMID:33007128) UniProt PMID:33007128 NCBI chr 2:219,209,772...219,218,958
Ensembl chr 2:219,209,772...219,218,994
JBrowse link
G BDH2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:103,077,592...103,099,834
Ensembl chr 4:103,077,592...103,099,870
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 acts_upstream_of_or_within ISO (PMID:16183037) MGI PMID:16183037 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G HMOX1 heme oxygenase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16183037) Ensembl
MGI
PMID:16183037 GO_REF:0000107 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HPX hemopexin involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:18556779) Ensembl
MGI
GO_Central
PMID:18556779 GO_REF:0000033 GO_REF:0000107 NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617
JBrowse link
G SLC46A1 solute carrier family 46 member 1 involved_in TAS Reactome Reactome:R-HSA-9707616 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197
JBrowse link
G SLC48A1 solute carrier family 48 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,753,934...47,782,751
Ensembl chr12:47,753,916...47,782,751
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11134514) Ensembl
MGI
PMID:11134514 GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G COX10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr17:14,069,504...14,208,677
Ensembl chr17:14,069,490...14,231,736
JBrowse link
G CPOX coproporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648
JBrowse link
G FECH ferrochelatase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732
JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288
JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 involved_in IEA
IBA
IDA
(PMID:17915953) InterPro
TreeGrafter
GO_Central
BHF-UCL
UniProt
PMID:17915953 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HMOX2 heme oxygenase 2 involved_in IEA
IBA
UniProt
GO_Central
TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr16:4,474,736...4,510,347
Ensembl chr16:4,474,690...4,510,347
JBrowse link
melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIP agouti signaling protein involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
(PMID:7665913) Ensembl
MGI
UniProt
PMID:7665913 GO_REF:0000024 GO_REF:0000107 NCBI chr20:34,186,493...34,269,344
Ensembl chr20:34,194,569...34,269,344
JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr  X:72,301,646...72,307,157
Ensembl chr  X:72,301,638...72,307,187
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter involved_in IEA UniProt GO_REF:0000043 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103
JBrowse link
G DCT dopachrome tautomerase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7665913) UniProt
MGI
Ensembl
PMID:7665913 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G DDT D-dopachrome tautomerase involved_in IEA UniProt GO_REF:0000043 NCBI chr22:23,971,370...23,980,504
Ensembl chr22:23,970,542...23,980,525
JBrowse link
G DDTL D-dopachrome tautomerase like involved_in IEA UniProt GO_REF:0000043 NCBI chr22:23,966,888...23,972,556
Ensembl chr22:23,966,888...23,972,556
Ensembl chr22:23,966,888...23,972,556
JBrowse link
G MC1R melanocortin 1 receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7665913) Ensembl
MGI
PMID:7665913 GO_REF:0000107 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:3,538,275...3,557,586
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (PMID:7665913) MGI PMID:7665913 NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,281...52,529,132
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:7665913), (PMID:9548375) Ensembl
MGI
GO_Central
TreeGrafter
PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:27,719,008...28,099,315
Ensembl chr15:27,754,875...28,099,315
JBrowse link
G PMEL premelanosome protein involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7665913) UniProt
MGI
Ensembl
PMID:7665913 GO_REF:0000043 GO_REF:0000107 NCBI chr12:55,954,105...55,966,709
Ensembl chr12:55,954,105...55,973,317
JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of
IEA
ISO
(PMID:18166528) Ensembl
MGI
PMID:18166528 GO_REF:0000107 NCBI chr15:48,120,990...48,142,672
Ensembl chr15:48,120,990...48,142,672
JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:33,944,623...33,984,693
Ensembl chr 5:33,944,623...33,984,693
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in IDA (PMID:8126111) CACAO PMID:8126111 NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888
JBrowse link
G TYR tyrosinase involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
IDA
(PMID:9548375)
(PMID:7665913)
(PMID:8126111)
Ensembl
MGI
TreeGrafter
GO_Central
UniProt
CACAO
PMID:7665913 PMID:8126111 PMID:9548375 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IEA
TAS
UniProt
Reactome
GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-5662702 NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase involved_in TAS
IEA
IBA
ISS
(PMID:8206391) PINC
TreeGrafter
GO_Central
Ensembl
UniProt
PMID:8206391 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in IDA (PMID:25513726), (PMID:32966160) UniProt PMID:25513726 PMID:32966160 NCBI chr15:27,719,008...28,099,315
Ensembl chr15:27,754,875...28,099,315
JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IDA
IEA
ISS
(PMID:32966160) UniProt
Ensembl
PMID:32966160 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:33,944,623...33,984,693
Ensembl chr 5:33,944,623...33,984,693
JBrowse link
G TYR tyrosinase involved_in TAS (PMID:7704033) PINC PMID:7704033 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
melanin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11709185) Ensembl
MGI
PMID:11709185 GO_REF:0000107 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (PMID:9548375) MGI PMID:9548375 NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,281...52,529,132
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9548375) Ensembl
MGI
PMID:9548375 GO_REF:0000107 NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
G VHL von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO (PMID:22627278) MGI PMID:22627278 NCBI chr 3:10,141,778...10,153,667
Ensembl chr 3:10,141,778...10,153,667
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,538,275...3,557,586
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G OPN3 opsin 3 involved_in IMP (PMID:31097585) UniProt PMID:31097585 NCBI chr 1:241,593,124...241,640,369
Ensembl chr 1:241,590,102...241,677,376
Ensembl chr 1:241,590,102...241,677,376
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:159,103,079...159,360,173
Ensembl chr 4:159,103,013...159,360,174
JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:18166528) Ensembl
MGI
PMID:18166528 GO_REF:0000107 NCBI chr15:48,120,990...48,142,672
Ensembl chr15:48,120,990...48,142,672
JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
pigment biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:12036291) MGI PMID:12036291 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
pigment metabolic process involved in pigmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA
IBA
IMP
(PMID:33208952) Ensembl
GO_Central
UniProt
PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr19:3,538,275...3,557,586
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G TBX2 T-box transcription factor 2 acts_upstream_of_negative_effect
involved_in
ISO
IEA
(MGI:6814712|PMID:26971330) UniProt
Ensembl
PMID:26971330 GO_REF:0000107 MGI:6814712 NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466
JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB10 ATP binding cassette subfamily B member 10 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:229,516,582...229,558,707
Ensembl chr 1:229,516,582...229,558,707
JBrowse link
G ABCB7 ATP binding cassette subfamily B member 7 involved_in IMP
IEA
ISS
(PMID:30765471) UniProt
Ensembl
PMID:30765471 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732
JBrowse link
G SLC6A9 solute carrier family 6 member 9 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 1:43,996,483...44,031,462
Ensembl chr 1:43,991,500...44,031,467
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IMP (PMID:21291857) UniProt PMID:21291857 NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105
JBrowse link
G ASIP agouti signaling protein involved_in IEA
IBA
Ensembl
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr20:34,186,493...34,269,344
Ensembl chr20:34,194,569...34,269,344
JBrowse link
G ATP7A ATPase copper transporting alpha involved_in IMP (PMID:11092760) UniProt PMID:11092760 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395
JBrowse link
G CDH3 cadherin 3 involved_in IMP (PMID:23334344) UniProt PMID:23334344 NCBI chr16:68,645,310...68,733,771
Ensembl chr16:68,636,189...68,727,468
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 involved_in IMP (PMID:21291857) UniProt PMID:21291857 NCBI chr19:14,477,762...14,496,127
Ensembl chr19:14,477,760...14,496,149
JBrowse link
G OPN3 opsin 3 involved_in IMP (PMID:28842328) UniProt PMID:28842328 NCBI chr 1:241,593,124...241,640,369
Ensembl chr 1:241,590,102...241,677,376
Ensembl chr 1:241,590,102...241,677,376
JBrowse link
G PMEL premelanosome protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:55,954,105...55,966,709
Ensembl chr12:55,954,105...55,973,317
JBrowse link
G RAB38 RAB38, member RAS oncogene family involved_in ISO
IEA
RGD
Ensembl
PMID:17043139 GO_REF:0000107 RGD:152025192 NCBI chr11:87,803,715...88,175,443
Ensembl chr11:88,113,251...88,175,443
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IMP
IEA
(PMID:21996312) CACAO
Ensembl
PMID:21996312 GO_REF:0000107 NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
G ZEB2 zinc finger E-box binding homeobox 2 involved_in IC (PMID:24769727) BHF-UCL PMID:24769727 NCBI chr 2:144,384,081...144,520,119
Ensembl chr 2:144,364,364...144,521,057
JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC021660.3 novel transcript involved_in IEA UniProt
TreeGrafter
GO_REF:0000041 GO_REF:0000118 Ensembl chr 3:98,521,133...98,585,498 JBrowse link
G ALAD aminolevulinate dehydratase involved_in IEA UniProt GO_REF:0000041 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G CPOX coproporphyrinogen oxidase involved_in ISO
IEA
IBA
RGD
TreeGrafter
GO_Central
UniProt
PMID:3814086 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 RGD:4145128 NCBI chr 3:98,570,488...98,593,611
Ensembl chr 3:98,579,446...98,593,648
JBrowse link
G HMBS hydroxymethylbilane synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15831703) Ensembl
MGI
PMID:15831703 GO_REF:0000107 NCBI chr15:78,437,431...78,501,453
Ensembl chr15:78,437,431...78,501,453
JBrowse link
G PPOX protoporphyrinogen oxidase involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013
JBrowse link
G UROD uroporphyrinogen decarboxylase involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:45,012,254...45,015,575
Ensembl chr 1:45,010,950...45,015,575
JBrowse link
G UROS uroporphyrinogen III synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr10:125,784,980...125,823,258
Ensembl chr10:125,784,980...125,823,288
JBrowse link
quercetin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LCT lactase involved_in IDA (PMID:12594539) UniProt PMID:12594539 NCBI chr 2:135,787,850...135,837,184
Ensembl chr 2:135,787,850...135,837,184
JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SRRD SRR1 domain containing involved_in ISS UniProt GO_REF:0000024 NCBI chr22:26,483,877...26,494,658
Ensembl chr22:26,483,877...26,494,658
JBrowse link
G TMEM14A transmembrane protein 14A involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 6:52,671,113...52,686,588
Ensembl chr 6:52,671,113...52,686,588
JBrowse link
G TMEM14B transmembrane protein 14B involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 6:10,747,759...10,759,774
Ensembl chr 6:10,747,759...10,852,753
JBrowse link
G TMEM14C transmembrane protein 14C involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:25157825) Ensembl
MGI
TreeGrafter
GO_Central
PMID:25157825 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:10,723,070...10,731,127
Ensembl chr 6:10,722,915...10,731,129
JBrowse link
G TMEM14DP transmembrane protein 14D, pseudogene involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr10:68,544,026...68,544,940
Ensembl chr10:68,544,489...68,544,833
JBrowse link
G TMEM14EP transmembrane protein 14E, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:152,339,698...152,340,990
Ensembl chr 3:152,339,695...152,340,990
Ensembl chr 3:152,339,695...152,340,990
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in IMP (PMID:22649030) UniProt PMID:22649030 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in IMP
IBA
IEA
(PMID:33208952) UniProt
GO_Central
Ensembl
PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr19:3,538,275...3,557,586
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16037214) Ensembl
MGI
PMID:16037214 GO_REF:0000107 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
rhodopsin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:17573483 RGD:5685371 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294
JBrowse link
xanthophyll biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COQ6 coenzyme Q6, monooxygenase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:73,949,926...73,963,670
Ensembl chr14:73,949,926...73,963,670
JBrowse link
zeaxanthin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPE65 retinoid isomerohydrolase RPE65 involved_in IDA
IBA
IEA
(PMID:28874556) UniProt
GO_Central
TreeGrafter
PMID:28874556 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:68,428,822...68,449,954
Ensembl chr 1:68,428,822...68,449,954
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    metabolic process 12509
      pigment metabolic process 93
        anthocyanin-containing compound metabolic process + 0
        aurone metabolic process + 0
        flavone metabolic process + 8
        heme metabolic process + 51
        melanin metabolic process + 28
        phlobaphene metabolic process + 0
        pigment biosynthetic process + 66
        pigment catabolic process + 11
        pigment metabolic process involved in pigmentation + 5
paths to the root