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ONTOLOGY REPORT - ANNOTATIONS


Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in ISO (MGI:4412464|PMID:11434569) UniProt PMID:11434569 MGI:4412464 NCBI chrNW_004936762:1,387,354...1,392,955 JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chrNW_004936472:15,074,947...15,110,427 JBrowse link
G LOC101978402 agouti signaling protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chrNW_004936561:6,341,667...6,346,440 JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chrNW_004936641:193,885...198,730 JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chrNW_004936471:14,105,832...14,257,386 JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within ISO (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913) MGI PMID:7665913 PMID:9548375 MGI:1202196 MGI:76308 NCBI chrNW_004936471:38,612,450...38,952,150 JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chrNW_004936646:368,064...379,085 JBrowse link
G Trpc1 transient receptor potential cation channel subfamily C member 1 involved_in ISO (PMID:8126111) CACAO PMID:8126111 NCBI chrNW_004936540:4,340,672...4,417,655 JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within
ISO (PMID:8126111)
(MGI:1202196|PMID:9548375)
(MGI:76308|PMID:7665913)
CACAO
MGI
PMID:7665913 PMID:8126111 PMID:9548375 MGI:1202196 MGI:76308 NCBI chrNW_004936736:421,623...519,085 JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885) UniProt PMID:2169885 MGI:3690794 NCBI chrNW_004936472:15,074,947...15,110,427 JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (MGI:5912387|PMID:29025994) CACAO PMID:29025994 MGI:5912387 NCBI chrNW_004936588:2,011,838...2,019,119 JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:31097585) UniProt PMID:31097585 NCBI chrNW_004936526:8,833,495...8,876,631 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (MGI:5499726|PMID:16272156) UniProt PMID:16272156 MGI:5499726 NCBI chrNW_004936576:5,583,847...5,746,583 JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (MGI:3775882|PMID:18166528) MGI PMID:18166528 MGI:3775882 NCBI chrNW_004936471:10,470,078...10,492,334 JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO (MGI:5619434|PMID:23569434) CACAO PMID:23569434 MGI:5619434 NCBI chrNW_004936473:6,031,627...6,052,211 JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) UniProt PMID:21291857 NCBI chrNW_004936473:7,580,495...7,647,471 JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISO (PMID:11092760) UniProt PMID:11092760 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) UniProt PMID:23334344 NCBI chrNW_004936475:18,908,031...18,954,402 JBrowse link
G Gipc1 GIPC PDZ domain containing family member 1 involved_in ISO (PMID:21291857) UniProt PMID:21291857 NCBI chrNW_004936659:3,019,829...3,030,280 JBrowse link
G LOC101978402 agouti signaling protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chrNW_004936561:6,341,667...6,346,440 JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:28842328) UniProt PMID:28842328 NCBI chrNW_004936526:8,833,495...8,876,631 JBrowse link
G Pmel premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chrNW_004936646:368,064...379,085 JBrowse link
G Tyrp1 tyrosinase related protein 1 involved_in ISO (PMID:21996312)
(MGI:5294257|PMID:21949658)
CACAO PMID:21949658 PMID:21996312 MGI:5294257 NCBI chrNW_004936539:6,537,448...6,555,440 JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) UniProt PMID:22649030 NCBI chrNW_004936677:342,964...360,890 JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:31117290)
(MGI:6492453|PMID:33208952)
(PMID:33208952)
UniProt PMID:31117290 PMID:33208952 MGI:6492453 NCBI chrNW_004936588:2,011,838...2,019,119 JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO (MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:3588610 NCBI chrNW_004936535:9,177,305...9,242,743 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12166
    metabolic process 7641
      secondary metabolic process 46
        secondary metabolite biosynthetic process 23
          melanin biosynthetic process 21
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 1
            negative regulation of melanin biosynthetic process 5
            positive regulation of melanin biosynthetic process 8
            regulation of melanin biosynthetic process + 14
Path 2
Term Annotations click to browse term
  biological_process 12166
    metabolic process 7641
      cellular metabolic process 7019
        cellular aromatic compound metabolic process 3794
          phenol-containing compound metabolic process 107
            melanin metabolic process 23
              melanin biosynthetic process 21
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 1
                negative regulation of melanin biosynthetic process 5
                positive regulation of melanin biosynthetic process 8
                regulation of melanin biosynthetic process + 14
paths to the root