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ONTOLOGY REPORT - ANNOTATIONS

Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIP agouti signaling protein involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 (PMID:7665913) Ensembl
MGI
UniProt		 PMID:7665913 GO_REF:0000024 GO_REF:0000107 NCBI chr17:37,542,615...37,718,787
Ensembl chr17:37,545,474...37,718,779 		JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:58,179,084...58,184,778
Ensembl chr  X:58,179,087...58,184,499 		JBrowse link
G DCT dopachrome tautomerase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7665913) UniProt
MGI		 PMID:7665913 GO_REF:0000041 GO_REF:0000043 NCBI chr11:63,584,865...63,647,486
Ensembl chr11:63,584,869...63,678,344 		JBrowse link
G DDT D-dopachrome tautomerase involved_in IEA UniProt GO_REF:0000043 NCBI chr14:49,790,794...49,793,196
Ensembl chr14:49,790,804...49,793,357 		JBrowse link
G MC1R melanocortin 1 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7665913) Ensembl
MGI		 PMID:7665913 GO_REF:0000107 NCBI chr 6:181,225...182,187
Ensembl chr 6:181,225...182,187 		JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (PMID:7665913) MGI PMID:7665913 NCBI chr 1:119,165,751...119,398,591
Ensembl chr 1:119,165,942...119,394,725 		JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:7665913), (PMID:9548375) TreeGrafter
MGI
GO_Central		 PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000118 NCBI chr15:56,657,648...56,869,920
Ensembl chr15:56,657,616...56,869,918 		JBrowse link
G PMEL premelanosome protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7665913) Ensembl
MGI		 PMID:7665913 GO_REF:0000107 NCBI chr 5:21,355,611...21,365,609
Ensembl chr 5:21,355,619...21,364,987 		JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18166528) Ensembl
MGI		 PMID:18166528 GO_REF:0000107 NCBI chr 1:123,635,077...123,657,205
Ensembl chr 1:123,635,043...123,656,736 		JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:19,958,315...20,002,198
Ensembl chr16:19,956,366...20,023,289 		JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:83,436,343...83,498,419
Ensembl chr13:83,436,395...83,498,478 		JBrowse link
G TYR tyrosinase involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:7665913)
(PMID:9548375)		 UniProt
MGI
TreeGrafter
GO_Central
Ensembl		 PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:22,517,047...22,604,290
Ensembl chr 9:22,517,047...22,604,290 		JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:209,725,698...209,745,141
Ensembl chr 1:209,725,638...209,745,705 		JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMACR alpha-methylacyl-CoA racemase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:20,005,741...20,023,339
Ensembl chr16:19,956,366...20,023,289 		JBrowse link
G DCT dopachrome tautomerase involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr11:63,584,865...63,647,486
Ensembl chr11:63,584,869...63,678,344 		JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:56,657,648...56,869,920
Ensembl chr15:56,657,616...56,869,918 		JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:19,958,315...20,002,198
Ensembl chr16:19,956,366...20,023,289 		JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,098,531...75,120,795
Ensembl chr 2:75,107,529...75,120,705 		JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISO (MGI:5499726|PMID:16272156) UniProt PMID:16272156 MGI:5499726 NCBI chr 8:48,183,518...48,277,476
Ensembl chr 8:48,021,604...48,277,454 		JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18166528) Ensembl
MGI		 PMID:18166528 GO_REF:0000107 NCBI chr 1:123,635,077...123,657,205
Ensembl chr 1:123,635,043...123,656,736 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207 		JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,077...39,129,781 		JBrowse link
G ASIP agouti signaling protein involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:37,542,615...37,718,787
Ensembl chr17:37,545,474...37,718,779 		JBrowse link
G ATP7A ATPase copper transporting alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,991...62,110,048 		JBrowse link
G CDH3 cadherin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:18,190,971...18,236,184
Ensembl chr 6:18,191,664...18,235,862 		JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:64,780,447...64,794,922
Ensembl chr 2:64,780,442...64,794,919 		JBrowse link
G PMEL premelanosome protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,355,611...21,365,609
Ensembl chr 5:21,355,619...21,364,987 		JBrowse link
G RAB38 RAB38, member RAS oncogene family ISO RGD PMID:17043139 RGD:152025192 NCBI chr 9:21,577,083...21,640,637
Ensembl chr 9:21,577,033...21,640,115 		JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:209,725,698...209,745,141
Ensembl chr 1:209,725,638...209,745,705 		JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,043 		JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,098,531...75,120,795
Ensembl chr 2:75,107,529...75,120,705 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16037214) Ensembl
MGI		 PMID:16037214 GO_REF:0000107 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,608,174...88,687,250 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    metabolic process 10347
      secondary metabolic process 65
        secondary metabolite biosynthetic process 27
          melanin biosynthetic process 24
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 4
            negative regulation of melanin biosynthetic process 4
            positive regulation of melanin biosynthetic process 8
            regulation of melanin biosynthetic process + 14
Path 2
Term Annotations click to browse term
  biological_process 17813
    metabolic process 10347
      cellular metabolic process 9044
        cellular aromatic compound metabolic process 5337
          phenol-containing compound metabolic process 131
            melanin metabolic process 26
              melanin biosynthetic process 24
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 4
                negative regulation of melanin biosynthetic process 4
                positive regulation of melanin biosynthetic process 8
                regulation of melanin biosynthetic process + 14
paths to the root