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ONTOLOGY REPORT - ANNOTATIONS


Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIP agouti signaling protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr17:37,542,615...37,718,787 JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:58,179,084...58,184,778
Ensembl chr  X:58,179,087...58,184,499
JBrowse link
G DCT dopachrome tautomerase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) UniProt
MGI
PMID:7665913 GO_REF:0000043 MGI:76308 NCBI chr11:63,584,865...63,647,486
Ensembl chr11:63,584,866...63,678,314
JBrowse link
G MC1R melanocortin 1 receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) Ensembl
MGI
PMID:7665913 GO_REF:0000107 MGI:76308 NCBI chr 6:181,225...182,187
Ensembl chr 6:181,225...182,187
JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr 1:119,165,751...119,398,591
Ensembl chr 1:119,134,313...119,394,725
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within ISO (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913) MGI PMID:7665913 PMID:9548375 MGI:1202196 MGI:76308 NCBI chr15:56,657,648...56,869,920 JBrowse link
G PMEL premelanosome protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr 5:21,355,611...21,365,609
Ensembl chr 5:21,355,619...21,365,068
JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:19,958,315...20,002,198
Ensembl chr16:19,952,451...20,023,285
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:83,436,343...83,498,419
Ensembl chr13:83,436,395...83,498,422
JBrowse link
G TYR tyrosinase involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1202196|PMID:9548375)
(MGI:76308|PMID:7665913)
GO_Central
MGI
PMID:7665913 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308 NCBI chr 9:22,517,047...22,604,290
Ensembl chr 9:22,517,047...22,604,290
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:209,725,698...209,745,141
Ensembl chr 1:209,725,636...209,745,705
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase involved_in ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr11:63,584,865...63,647,486
Ensembl chr11:63,584,866...63,678,314
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,098,531...75,120,795
Ensembl chr 2:75,107,212...75,120,708
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISO (MGI:5499726|PMID:16272156) UniProt PMID:16272156 MGI:5499726 NCBI chr 8:48,183,518...48,277,476
Ensembl chr 8:48,020,697...48,277,476
JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3775882|PMID:18166528) Ensembl
MGI
PMID:18166528 GO_REF:0000107 MGI:3775882 NCBI chr 1:123,635,077...123,657,205
Ensembl chr 1:123,635,039...123,656,737
JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,344,684...37,367,215
Ensembl chr13:37,344,699...37,367,207
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,045...39,129,781
JBrowse link
G ASIP agouti signaling protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chr17:37,542,615...37,718,787 JBrowse link
G ATP7A ATPase copper transporting alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058
JBrowse link
G CDH3 cadherin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:18,190,971...18,236,184
Ensembl chr 6:18,191,664...18,235,862
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:64,780,447...64,794,922
Ensembl chr 2:64,780,442...64,798,783
JBrowse link
G PMEL premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chr 5:21,355,611...21,365,609
Ensembl chr 5:21,355,619...21,365,068
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:209,725,698...209,745,141
Ensembl chr 1:209,725,636...209,745,705
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,208
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:31117290)
(MGI:6492453|PMID:33208952)
(PMID:33208952)
UniProt PMID:31117290 PMID:33208952 MGI:6492453 NCBI chr 2:75,098,531...75,120,795
Ensembl chr 2:75,107,212...75,120,708
JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3588610|PMID:16037214) Ensembl
MGI
PMID:16037214 GO_REF:0000107 MGI:3588610 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,607,884...88,940,100
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16573
    metabolic process 10410
      secondary metabolic process 54
        secondary metabolite biosynthetic process 23
          melanin biosynthetic process 21
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 1
            negative regulation of melanin biosynthetic process 4
            positive regulation of melanin biosynthetic process 7
            regulation of melanin biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 16573
    metabolic process 10410
      cellular metabolic process 9486
        cellular aromatic compound metabolic process 5131
          phenol-containing compound metabolic process 118
            melanin metabolic process 23
              melanin biosynthetic process 21
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 1
                negative regulation of melanin biosynthetic process 4
                positive regulation of melanin biosynthetic process 7
                regulation of melanin biosynthetic process + 13
paths to the root