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ONTOLOGY REPORT - ANNOTATIONS


Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIP agouti signaling protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) Ensembl
MGI
PMID:7665913 GO_REF:0000107 MGI:76308 NCBI chr20:34,186,493...34,269,344
Ensembl chr20:34,194,569...34,269,344
JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr  X:72,301,646...72,307,157
Ensembl chr  X:72,301,638...72,307,187
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter involved_in IEA UniProt GO_REF:0000043 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103
JBrowse link
G DCT dopachrome tautomerase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) UniProt
MGI
PMID:7665913 GO_REF:0000043 MGI:76308 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G DDT D-dopachrome tautomerase involved_in IEA UniProt GO_REF:0000043 NCBI chr22:23,971,370...23,979,828
Ensembl chr22:23,971,365...23,979,828
JBrowse link
G MC1R melanocortin 1 receptor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) Ensembl
MGI
PMID:7665913 GO_REF:0000107 MGI:76308 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:3,538,270...3,557,592
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,283...52,529,050
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913) Ensembl
MGI
PMID:7665913 PMID:9548375 GO_REF:0000107 MGI:1202196 MGI:76308 NCBI chr15:27,719,008...28,099,342
Ensembl chr15:27,754,875...28,099,315
JBrowse link
G PMEL premelanosome protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76308|PMID:7665913) UniProt
MGI
PMID:7665913 GO_REF:0000043 MGI:76308 NCBI chr12:55,954,105...55,966,709
Ensembl chr12:55,954,105...55,973,317
JBrowse link
G SLC45A2 solute carrier family 45 member 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:33,944,623...33,984,693
Ensembl chr 5:33,944,623...33,984,693
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in IDA (PMID:8126111) CACAO PMID:8126111 NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888
JBrowse link
G TYR tyrosinase involved_in
acts_upstream_of_or_within
IDA
ISO
IBA
(PMID:8126111)
(MGI:76308|PMID:7665913)
(MGI:1202196|PMID:9548375)
(PMID:21873635)
CACAO
MGI
GO_Central
PMID:7665913 PMID:8126111 PMID:9548375 PMID:21873635 MGI:1202196 MGI:76308 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in TAS
IEA
Reactome
UniProt
GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-5662702 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase involved_in IBA
ISS
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000024 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G TYR tyrosinase involved_in TAS (PMID:7704033) PINC PMID:7704033 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,538,270...3,557,592
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G OPN3 opsin 3 involved_in IMP (PMID:31097585) UniProt PMID:31097585 NCBI chr 1:241,593,124...241,640,369
Ensembl chr 1:241,590,102...241,677,376
Ensembl chr 1:241,590,102...241,677,376
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:159,103,079...159,360,173
Ensembl chr 4:159,103,013...159,360,174
JBrowse link
G SLC24A5 solute carrier family 24 member 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3775882|PMID:18166528) Ensembl
MGI
PMID:18166528 GO_REF:0000107 MGI:3775882 NCBI chr15:48,120,990...48,142,672
Ensembl chr15:48,120,990...48,142,672
JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IMP (PMID:21291857) UniProt PMID:21291857 NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105
JBrowse link
G ASIP agouti signaling protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:34,186,493...34,269,344
Ensembl chr20:34,194,569...34,269,344
JBrowse link
G ATP7A ATPase copper transporting alpha involved_in IMP (PMID:11092760) UniProt PMID:11092760 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G CDH3 cadherin 3 involved_in IMP (PMID:23334344) UniProt PMID:23334344 NCBI chr16:68,644,914...68,727,573
Ensembl chr16:68,636,189...68,727,468
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 involved_in IMP (PMID:21291857) UniProt PMID:21291857 NCBI chr19:14,477,761...14,496,133
Ensembl chr19:14,477,760...14,496,149
JBrowse link
G OPN3 opsin 3 involved_in IMP (PMID:28842328) UniProt PMID:28842328 NCBI chr 1:241,593,124...241,640,369
Ensembl chr 1:241,590,102...241,677,376
Ensembl chr 1:241,590,102...241,677,376
JBrowse link
G PMEL premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chr12:55,954,105...55,966,709
Ensembl chr12:55,954,105...55,973,317
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in IMP (PMID:21996312) CACAO PMID:21996312 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
G ZEB2 zinc finger E-box binding homeobox 2 involved_in IC (PMID:24769727) BHF-UCL PMID:24769727 NCBI chr 2:144,384,081...144,520,119
Ensembl chr 2:144,364,364...144,521,057
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in IMP (PMID:22649030) UniProt PMID:22649030 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in IMP (PMID:33208952) UniProt PMID:33208952 NCBI chr19:3,538,270...3,557,592
Ensembl chr19:3,538,261...3,574,290
JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3588610|PMID:16037214) Ensembl
MGI
PMID:16037214 GO_REF:0000107 MGI:3588610 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18532
    metabolic process 11860
      secondary metabolic process 67
        secondary metabolite biosynthetic process 26
          melanin biosynthetic process 24
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 2
            negative regulation of melanin biosynthetic process 5
            positive regulation of melanin biosynthetic process 9
            regulation of melanin biosynthetic process + 15
Path 2
Term Annotations click to browse term
  biological_process 18532
    metabolic process 11860
      cellular metabolic process 10837
        cellular aromatic compound metabolic process 6052
          phenol-containing compound metabolic process 133
            melanin metabolic process 26
              melanin biosynthetic process 24
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 2
                negative regulation of melanin biosynthetic process 5
                positive regulation of melanin biosynthetic process 9
                regulation of melanin biosynthetic process + 15
paths to the root