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ONTOLOGY REPORT - ANNOTATIONS


Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASIP agouti signaling protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr20:30,583,038...30,592,726
Ensembl chr20:31,718,169...31,727,217
JBrowse link
G CITED1 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 involved_in ISO (MGI:4412464|PMID:11434569) UniProt PMID:11434569 MGI:4412464 NCBI chr  X:61,537,949...61,543,545
Ensembl chr  X:71,621,785...71,625,702
JBrowse link
G DCT dopachrome tautomerase acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr13:75,590,366...75,730,956
Ensembl chr13:94,773,794...94,816,083
JBrowse link
G MYO5A myosin VA acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr15:31,246,192...31,470,040
Ensembl chr15:49,578,491...49,704,319
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within ISO (MGI:1202196|PMID:9548375), (MGI:76308|PMID:7665913) MGI PMID:7665913 PMID:9548375 MGI:1202196 MGI:76308 NCBI chr15:1,811,728...2,192,018
Ensembl chr15:25,181,386...25,523,774
JBrowse link
G PMEL premelanosome protein acts_upstream_of_or_within ISO (MGI:76308|PMID:7665913) MGI PMID:7665913 MGI:76308 NCBI chr12:32,946,951...32,958,205
Ensembl chr12:33,196,040...33,207,610
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in ISO (PMID:8126111) CACAO PMID:8126111 NCBI chr 3:139,757,408...139,841,006
Ensembl chr 3:147,349,056...147,432,332
JBrowse link
G TYR tyrosinase involved_in
acts_upstream_of_or_within
ISO (PMID:8126111)
(MGI:76308|PMID:7665913)
(MGI:1202196|PMID:9548375)
CACAO
MGI
PMID:7665913 PMID:8126111 PMID:9548375 MGI:1202196 MGI:76308 NCBI chr11:84,188,557...84,306,686
Ensembl chr11:87,769,606...87,888,138
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885) UniProt PMID:2169885 MGI:3690794 NCBI chr13:75,590,366...75,730,956
Ensembl chr13:94,773,794...94,816,083
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MFSD12 major facilitator superfamily domain containing 12 involved_in ISO (MGI:5912387|PMID:29025994) CACAO PMID:29025994 MGI:5912387 NCBI chr19:2,570,068...2,583,505
Ensembl chr19:3,520,399...3,532,767
JBrowse link
G OPN3 opsin 3 involved_in ISO (PMID:31097585) UniProt PMID:31097585 NCBI chr 1:217,155,765...217,202,577
Ensembl chr 1:222,136,422...222,184,598
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISO (MGI:5499726|PMID:16272156) UniProt PMID:16272156 MGI:5499726 NCBI chr 4:151,419,402...151,680,769
Ensembl chr 4:163,316,396...163,487,495
JBrowse link
G SLC24A5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (MGI:3775882|PMID:18166528) MGI PMID:18166528 MGI:3775882 NCBI chr15:27,069,937...27,091,619
Ensembl chr15:45,394,090...45,415,823
JBrowse link
G WNT5A Wnt family member 5A involved_in ISO (MGI:5619434|PMID:23569434) CACAO PMID:23569434 MGI:5619434 NCBI chr 3:55,396,279...55,418,579
Ensembl chr 3:56,621,380...56,638,051
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) UniProt PMID:21291857 NCBI chr 3:57,161,299...57,206,672
Ensembl chr 3:58,370,430...58,415,258
JBrowse link
G ASIP agouti signaling protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chr20:30,583,038...30,592,726
Ensembl chr20:31,718,169...31,727,217
JBrowse link
G ATP7A ATPase copper transporting alpha involved_in ISO (PMID:11092760) UniProt PMID:11092760 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756
JBrowse link
G CDH3 cadherin 3 involved_in ISO (PMID:23334344) UniProt PMID:23334344 NCBI chr16:49,015,115...49,071,903
Ensembl chr16:68,407,625...68,465,287
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 involved_in ISO (PMID:21291857) UniProt PMID:21291857 NCBI chr19:14,041,192...14,059,402
Ensembl chr19:14,885,185...14,889,701
JBrowse link
G OPN3 opsin 3 involved_in ISO (PMID:28842328) UniProt PMID:28842328 NCBI chr 1:217,155,765...217,202,577
Ensembl chr 1:222,136,422...222,184,598
JBrowse link
G PMEL premelanosome protein involved_in ISO (MGI:5294257|PMID:21949658) CACAO PMID:21949658 MGI:5294257 NCBI chr12:32,946,951...32,958,205
Ensembl chr12:33,196,040...33,207,610
JBrowse link
G TYRP1 tyrosinase related protein 1 involved_in ISO (PMID:21996312)
(MGI:5294257|PMID:21949658)
CACAO PMID:21949658 PMID:21996312 MGI:5294257 NCBI chr 9:12,502,610...12,550,203
Ensembl chr 9:12,950,831...12,996,799
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) UniProt PMID:22649030 NCBI chr17:3,686,903...3,711,857
Ensembl chr17:3,683,575...3,708,253
JBrowse link
G MFSD12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:31117290)
(MGI:6492453|PMID:33208952)
(PMID:33208952)
UniProt PMID:31117290 PMID:33208952 MGI:6492453 NCBI chr19:2,570,068...2,583,505
Ensembl chr19:3,520,399...3,532,767
JBrowse link
G SLC7A11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO (MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:3588610 NCBI chr 4:130,529,677...130,601,396
Ensembl chr 4:141,849,343...141,959,849
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12650
    metabolic process 7923
      secondary metabolic process 47
        secondary metabolite biosynthetic process 22
          melanin biosynthetic process 20
            1,8-dihydroxynaphthalene-melanin biosynthetic process 0
            melanin biosynthetic process from tyrosine 1
            negative regulation of melanin biosynthetic process 5
            positive regulation of melanin biosynthetic process 8
            regulation of melanin biosynthetic process + 14
Path 2
Term Annotations click to browse term
  biological_process 12650
    metabolic process 7923
      cellular metabolic process 7259
        cellular aromatic compound metabolic process 3904
          phenol-containing compound metabolic process 110
            melanin metabolic process 22
              melanin biosynthetic process 20
                1,8-dihydroxynaphthalene-melanin biosynthetic process 0
                melanin biosynthetic process from tyrosine 1
                negative regulation of melanin biosynthetic process 5
                positive regulation of melanin biosynthetic process 8
                regulation of melanin biosynthetic process + 14
paths to the root