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ONTOLOGY REPORT - ANNOTATIONS


Term:serotonin metabolic process
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Accession:GO:0042428 term browser browse the term
Definition:The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
Synonyms:exact_synonym: serotonin metabolism


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serotonin metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO MGI:MGI:1857092 (MGI:MGI:68065|PMID:2765934) RGD PMID:2765934 MGI:MGI:68065 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856098 (MGI:MGI:65000|PMID:8174230) RGD PMID:8174230 MGI:MGI:65000 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Btbd9 BTB domain containing 9 ISO MGI:MGI:4127237 (MGI:MGI:5436392|PMID:22678064) RGD PMID:22678064 MGI:MGI:5436392 NCBI chr20:8,899,286...9,253,936
Ensembl chr20:8,901,931...9,249,820
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO
IEA
MGI:MGI:1928285 (MGI:MGI:2384280|PMID:11160454)
GO_REF:0000107
RGD
Ensembl
PMID:11160454 GO_REF:0000107, MGI:MGI:2384280 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO
ISS
(MGI:MGI:1927024|PMID:11080193)
GO_REF:0000024
RGD
UniProt
PMID:11080193 GO_REF:0000024, MGI:MGI:1927024 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Maoa monoamine oxidase A IDA
IMP
Y402A, Y407A, Y410A had an impact on the properties of the protein while Y402F, Y410F had little effect; the residues are near the C406 FAD binding site RGD PMID:11754741, PMID:11754741, PMID:11263670 RGD:1600709, RGD:1600709, RGD:1600713 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Pde1b phosphodiesterase 1B ISO MGI:MGI:3604470 (MGI:MGI:3769297|PMID:17559891) RGD PMID:17559891 MGI:MGI:3769297 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Rnf180 ring finger protein 180 ISO
IBA
(MGI:MGI:5505713|PMID:23926250)
PMID:21873635
RGD PMID:23926250, PMID:21873635 MGI:MGI:5505713, RGD:13792537 NCBI chr 2:35,718,100...35,892,578
Ensembl chr 2:35,718,889...35,870,578
JBrowse link
G Spr sepiapterin reductase ISO MGI:MGI:3757641 (MGI:MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:MGI:3722569 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IEP RGD PMID:15936112 RGD:4891926 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
serotonin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:10027744, PMID:21873635 RGD:5129182, RGD:13792537 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Tph2 tryptophan hydroxylase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      nitrogen compound metabolic process 10366
        ammonium ion metabolic process 26
          serotonin metabolic process 14
            serotonin biosynthetic process + 4
            serotonin catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        cellular aromatic compound metabolic process 5715
          phenol-containing compound metabolic process 124
            serotonin metabolic process 14
              serotonin biosynthetic process + 4
              serotonin catabolic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.