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ONTOLOGY REPORT - ANNOTATIONS

Term:serotonin metabolic process
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Accession:GO:0042428 term browser browse the term
Definition:The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
Synonyms:exact_synonym: serotonin metabolism


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serotonin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857092 (MGI:68065|PMID:2765934) RGD PMID:2765934 MGI:68065 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856098 (MGI:65000|PMID:8174230) RGD PMID:8174230 MGI:65000 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Btbd9 BTB domain containing 9 acts_upstream_of_or_within ISO MGI:4127237 (MGI:5436392|PMID:22678064) RGD PMID:22678064 MGI:5436392 NCBI chr20:8,286,337...8,645,567
Ensembl chr20:8,288,711...8,643,960 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1928285 (MGI:2384280|PMID:11160454)		 Ensembl
RGD		 PMID:11160454 GO_REF:0000107 MGI:2384280 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A involved_in ISS
ISO		 GO_REF:0000024
(MGI:1927024|PMID:11080193)		 UniProt
RGD		 PMID:11080193 GO_REF:0000024 MGI:1927024 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Maoa monoamine oxidase A IDA
IMP		 Y402A, Y407A, Y410A had an impact on the properties of the protein while Y402F, Y410F had little effect; the residues are near the C406 FAD binding site RGD PMID:11754741 PMID:11754741 PMID:11263670 RGD:1600709, RGD:1600709, RGD:1600713 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Pde1b phosphodiesterase 1B acts_upstream_of_or_within ISO MGI:3604470 (MGI:3769297|PMID:17559891) RGD PMID:17559891 MGI:3769297 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Rnf180 ring finger protein 180 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:5505713|PMID:23926250)		 RGD PMID:23926250 PMID:21873635 MGI:5505713, RGD:13792537 NCBI chr 2:36,330,285...36,511,168
Ensembl chr 2:36,330,292...36,512,614 		JBrowse link
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:3722569 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IEP RGD PMID:15936112 RGD:4891926 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
regulation of serotonin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISS
ISO		 GO_REF:0000024
(MGI:6827320|PMID:26711020)		 UniProt
RGD		 PMID:26711020 GO_REF:0000024 MGI:6827320 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
serotonin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:10027744 PMID:21873635 RGD:5129182, RGD:13792537 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Tph1 tryptophan hydroxylase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2683993|PMID:14697203)		 UniProt
RGD		 PMID:14697203 GO_REF:0000024 MGI:2683993 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Tph2 tryptophan hydroxylase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      nitrogen compound metabolic process 8214
        ammonium ion metabolic process 27
          serotonin metabolic process 15
            serotonin biosynthetic process + 5
            serotonin catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      cellular metabolic process 7444
        cellular aromatic compound metabolic process 3032
          phenol-containing compound metabolic process 130
            serotonin metabolic process 15
              serotonin biosynthetic process + 5
              serotonin catabolic process 0
paths to the root