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ONTOLOGY REPORT - ANNOTATIONS


Term:serotonin biosynthetic process
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Accession:GO:0042427 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
Synonyms:exact_synonym: serotonin anabolism;   serotonin biosynthesis;   serotonin formation;   serotonin synthesis
 xref: Wikipedia:Serotonin


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serotonin biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:10027744, PMID:21873635 RGD:5129182, RGD:13792537 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Tph2 tryptophan hydroxylase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      nitrogen compound metabolic process 10366
        ammonium ion metabolic process 26
          serotonin metabolic process 14
            serotonin biosynthetic process 4
              negative regulation of serotonin biosynthetic process 0
              positive regulation of serotonin biosynthetic process 0
              regulation of serotonin biosynthetic process + 0
              serotonin biosynthetic process from tryptophan + 2
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      cellular metabolic process 11085
        cellular aromatic compound metabolic process 5715
          phenol-containing compound metabolic process 124
            serotonin metabolic process 14
              serotonin biosynthetic process 4
                negative regulation of serotonin biosynthetic process 0
                positive regulation of serotonin biosynthetic process 0
                regulation of serotonin biosynthetic process + 0
                serotonin biosynthetic process from tryptophan + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.