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ONTOLOGY REPORT - ANNOTATIONS


Term:catecholamine biosynthetic process
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Accession:GO:0042423 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Synonyms:exact_synonym: catecholamine anabolism;   catecholamine biosynthesis;   catecholamine formation;   catecholamine synthesis
 xref: Wikipedia:Catecholamines


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catecholamine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17194738 RGD:5131263 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Ddc dopa decarboxylase TAS
IEA
GO_REF:0000043 UniProt PMID:12047348 GO_REF:0000043, RGD:727571 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Hdc histidine decarboxylase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Th tyrosine hydroxylase IDA RGD PMID:20025246 RGD:4139888 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:20097214 RGD:6903884 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:20097214 RGD:6903884 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP RGD PMID:12438507 RGD:704388 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:19818757 RGD:5143981 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dao D-amino-acid oxidase IEA
ISO
GO_REF:0000107
(PMID:17303072)
Ensembl
RGD
PMID:17303072 GO_REF:0000107 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Ddc dopa decarboxylase IDA
IEA
GO_REF:0000041 UniProt PMID:12703659 GO_REF:0000041, RGD:4139893 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO (PMID:16338639) RGD PMID:16338639 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gpr37 G protein-coupled receptor 37 ISO MGI:MGI:3027995 (MGI:MGI:3046856|PMID:15218106) RGD PMID:15218106 MGI:MGI:3046856 NCBI chr 4:51,822,163...51,844,228
Ensembl chr 4:51,822,153...51,844,331
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IEA
ISO
GO_REF:0000107
MGI:MGI:2429971 (MGI:MGI:1203924|PMID:9608532), (MGI:MGI:3767764|PMID:16782508)
Ensembl
RGD
PMID:9608532, PMID:16782508 GO_REF:0000107, MGI:MGI:1203924, MGI:MGI:3767764 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO MGI:MGI:2386303 (MGI:MGI:2386819|PMID:9520487) RGD PMID:9520487 MGI:MGI:2386819 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Snca synuclein alpha ISO MGI:MGI:1888382 (MGI:MGI:1352916|PMID:10707987) RGD PMID:10707987 MGI:MGI:1352916 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
ISS
(MGI:MGI:3622848|PMID:16257223)
GO_REF:0000024
RGD
UniProt
PMID:16257223 GO_REF:0000024, MGI:MGI:3622848 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase IDA
IBA
ISO
IMP
PMID:21873635
MGI:MGI:1860450 (MGI:MGI:2386819|PMID:9520487), (MGI:MGI:72094|PMID:7715703), (MGI:MGI:77787|PMID:7592982)
PMID:11943812
RGD PMID:7592982, PMID:7715703, PMID:9520487, PMID:2427363, PMID:21873635, PMID:11943812, PMID:19584816 MGI:MGI:2386819, MGI:MGI:72094, MGI:MGI:77787, RGD:1580046, RGD:13792537, RGD:5129111, RGD:5130972 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine-N-methyltransferase TAS
IEA
IDA
IC
GO_REF:0000041 UniProt PMID:11514309, PMID:7914070, PMID:7503429 GO_REF:0000041, RGD:628457, RGD:4139902, RGD:4139901 NCBI chr10:86,340,893...86,342,501
Ensembl chr10:86,340,940...86,342,858
JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856097|MGI:MGI:1856098 (MGI:MGI:53801|PMID:4405722), (MGI:MGI:53940|PMID:4858102) RGD PMID:4405722, PMID:4858102 MGI:MGI:53801, MGI:MGI:53940 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Dbh dopamine beta-hydroxylase TAS
IBA
ISO
ISS
IEA
IMP
PMID:21873635
MGI:MGI:1857556 (MGI:MGI:1203930|PMID:9603211), (MGI:MGI:1332340|PMID:10051631), (MGI:MGI:5787847|PMID:27148966), (MGI:MGI:72180|PMID:7715704)
GO_REF:0000024
(PMID:27148966)
GO_REF:0000041
RGD
UniProt
PMID:7715704, PMID:9603211, PMID:10051631, PMID:27148966, PMID:11914591, PMID:21873635, PMID:10573542 GO_REF:0000024, GO_REF:0000041, MGI:MGI:1203930, MGI:MGI:1332340, MGI:MGI:5787847, MGI:MGI:72180, RGD:727567, RGD:13792537, RGD:1625403 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Gata3 GATA binding protein 3 ISO
ISS
MGI:MGI:2153826 (MGI:MGI:1859081|PMID:10835639)
GO_REF:0000024
RGD
UniProt
PMID:10835639 GO_REF:0000024, MGI:MGI:1859081 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3772428|PMID:18094025) RGD PMID:18094025 MGI:MGI:3772428 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:22,124,498...22,206,565
Ensembl chr 1:22,124,495...22,206,505
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,117,477...69,125,972
Ensembl chr 4:69,117,477...69,125,972
JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
IEA
ISS
(PMID:19703902)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
ParkinsonsUK-UCL
PMID:19703902 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Vps35 VPS35 retromer complex component ISO (MGI:MGI:5694519|PMID:26203154) RGD PMID:26203154 MGI:MGI:5694519 NCBI chr19:27,464,937...27,500,636
Ensembl chr19:27,464,937...27,500,636
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
(MGI:MGI:4413411|PMID:19008477)
GO_REF:0000107
RGD
Ensembl
PMID:19008477 GO_REF:0000107, MGI:MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      biosynthetic process 6217
        organic substance biosynthetic process 6115
          organonitrogen compound biosynthetic process 2029
            catecholamine biosynthetic process 27
              dopamine biosynthetic process + 16
              epinephrine biosynthetic process 2
              norepinephrine biosynthetic process + 10
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular aromatic compound metabolic process 5708
          phenol-containing compound metabolic process 123
            catechol-containing compound metabolic process 59
              catecholamine metabolic process 59
                catecholamine biosynthetic process 27
                  dopamine biosynthetic process + 16
                  epinephrine biosynthetic process 2
                  norepinephrine biosynthetic process + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.