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ONTOLOGY REPORT - ANNOTATIONS


Term:norepinephrine biosynthetic process
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Accession:GO:0042421 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol biosynthesis;   levarterenol biosynthetic process;   noradrenaline biosynthesis;   noradrenaline biosynthetic process;   norepinephrine anabolism;   norepinephrine biosynthesis;   norepinephrine formation;   norepinephrine synthesis



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norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097|MGI:1856098 (MGI:53801|PMID:4405722), (MGI:53940|PMID:4858102) RGD PMID:4405722 PMID:4858102 MGI:53801 MGI:53940 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
TAS
ISO
ISS
IBA
IEA
IMP
(MGI:5787847|PMID:27148966), (MGI:72180|PMID:7715704)
MGI:1857556 (MGI:1203930|PMID:9603211), (MGI:1332340|PMID:10051631)
(PMID:27148966)
GO_REF:0000024
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:7715704 PMID:9603211 PMID:10051631 PMID:27148966 PMID:11914591 More... GO_REF:0000024 GO_REF:0000041 MGI:1203930 MGI:1332340 MGI:5787847 MGI:72180, RGD:727567, RGD:13792537, RGD:1625403 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2153826 (MGI:1859081|PMID:10835639)
UniProt
RGD
PMID:10835639 GO_REF:0000024 MGI:1859081 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (MGI:3772428|PMID:18094025) RGD PMID:18094025 MGI:3772428 NCBI chr 3:133,639,790...133,642,963 JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:21,075,124...21,165,348
Ensembl chr 1:21,075,122...21,161,779
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,724,693...69,733,188
Ensembl chr 4:69,724,239...69,733,299
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:4413411|PMID:19008477)
Ensembl
RGD
PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19504
    metabolic process 11814
      cellular metabolic process 10733
        cellular aromatic compound metabolic process 5604
          aromatic compound biosynthetic process 3816
            phenol-containing compound biosynthetic process 50
              catechol-containing compound biosynthetic process 27
                catecholamine biosynthetic process 27
                  norepinephrine biosynthetic process 10
                    positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process 1
Path 2
Term Annotations click to browse term
  biological_process 19504
    metabolic process 11814
      organic substance metabolic process 11356
        organonitrogen compound metabolic process 6819
          amine metabolic process 127
            cellular amine metabolic process 119
              cellular biogenic amine metabolic process 106
                catecholamine metabolic process 63
                  catecholamine biosynthetic process 27
                    norepinephrine biosynthetic process 10
                      positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process 1
paths to the root