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ONTOLOGY REPORT - ANNOTATIONS


Term:norepinephrine biosynthetic process
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Accession:GO:0042421 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol biosynthesis;   levarterenol biosynthetic process;   noradrenaline biosynthesis;   noradrenaline biosynthetic process;   norepinephrine anabolism;   norepinephrine biosynthesis;   norepinephrine formation;   norepinephrine synthesis


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norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856097|MGI:MGI:1856098 (MGI:MGI:53801|PMID:4405722), (MGI:MGI:53940|PMID:4858102) RGD PMID:4405722, PMID:4858102 MGI:MGI:53801, MGI:MGI:53940 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Dbh dopamine beta-hydroxylase TAS
IBA
ISO
ISS
IEA
IMP
PMID:21873635
MGI:MGI:1857556 (MGI:MGI:1203930|PMID:9603211), (MGI:MGI:1332340|PMID:10051631), (MGI:MGI:5787847|PMID:27148966), (MGI:MGI:72180|PMID:7715704)
GO_REF:0000024
(PMID:27148966)
GO_REF:0000041
RGD
UniProt
PMID:7715704, PMID:9603211, PMID:10051631, PMID:27148966, PMID:11914591, PMID:21873635, PMID:10573542 GO_REF:0000024, GO_REF:0000041, MGI:MGI:1203930, MGI:MGI:1332340, MGI:MGI:5787847, MGI:MGI:72180, RGD:727567, RGD:13792537, RGD:1625403 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Gata3 GATA binding protein 3 ISO
ISS
MGI:MGI:2153826 (MGI:MGI:1859081|PMID:10835639)
GO_REF:0000024
RGD
UniProt
PMID:10835639 GO_REF:0000024, MGI:MGI:1859081 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3772428|PMID:18094025) RGD PMID:18094025 MGI:MGI:3772428 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:22,124,498...22,206,565
Ensembl chr 1:22,124,495...22,206,505
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,117,477...69,125,972
Ensembl chr 4:69,117,477...69,125,972
JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
(MGI:MGI:4413411|PMID:19008477)
GO_REF:0000107
RGD
Ensembl
PMID:19008477 GO_REF:0000107, MGI:MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      biosynthetic process 6217
        organic substance biosynthetic process 6115
          organonitrogen compound biosynthetic process 2029
            catecholamine biosynthetic process 27
              norepinephrine biosynthetic process 10
                positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular aromatic compound metabolic process 5708
          phenol-containing compound metabolic process 123
            catechol-containing compound metabolic process 59
              catecholamine metabolic process 59
                norepinephrine metabolic process 17
                  norepinephrine biosynthetic process 10
                    positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.