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ONTOLOGY REPORT - ANNOTATIONS


Term:dopamine metabolic process
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Accession:GO:0042417 term browser browse the term
Definition:The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
Synonyms:exact_synonym: dopamine metabolism



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dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856098|MGI:1856466 (MGI:50550|PMID:1752214), (MGI:65000|PMID:8174230) RGD PMID:1752214 PMID:8174230 MGI:50550 MGI:65000 MGI:71923 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Comt catechol-O-methyltransferase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5510279|PMID:23863468)
MGI:2178542|MGI:4830700 (MGI:4830461|PMID:19930170)
RGD PMID:19930170 PMID:23863468 PMID:21873635 MGI:4830461 MGI:5510279, RGD:13792537 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:10945868 RGD:1599723 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Ddc dopa decarboxylase TAS RGD PMID:7567987 RGD:727686 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO (MGI:68905|PMID:7925842) RGD PMID:7925842 MGI:68905 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1928285 (MGI:2384280|PMID:11160454)
Ensembl
RGD
PMID:11160454 GO_REF:0000107 MGI:2384280 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within ISO MGI:1857299 (MGI:1321418|PMID:9886073), (MGI:65825|PMID:7509865), (MGI:65928|PMID:1432691) RGD PMID:1432691 PMID:7509865 PMID:9886073 MGI:1321418 MGI:65825 MGI:65928 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Lrtomt leucine rich transmembrane and O-methyltransferase domain containing involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:156,266,655...156,268,704
Ensembl chr 1:156,266,655...156,268,704
JBrowse link
G Myo5a myosin VA IMP RGD PMID:29217155 RGD:42721980 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 acts_upstream_of_or_within ISO MGI:3527173 (MGI:6150107|PMID:28327638) RGD PMID:28327638 MGI:6150107 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Npr1 natriuretic peptide receptor 1 IMP RGD PMID:15544851 RGD:1580153 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 acts_upstream_of_or_within ISO MGI:2429971 (MGI:3529728|PMID:12385813) RGD PMID:12385813 MGI:3529728 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
ISO MGI:2678247 (MGI:2675710|PMID:12915482)
MGI:3055212 (MGI:3525458|PMID:15684050)
RGD PMID:12915482 PMID:15684050 MGI:2675710 MGI:3525458 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (MGI:5904876|PMID:28507136) RGD PMID:28507136 MGI:5904876 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:1889011 (MGI:3057254|PMID:15465911) RGD PMID:15465911 MGI:3057254 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sncaip synuclein, alpha interacting protein involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:14506261)
ParkinsonsUK-UCL
RGD
PMID:14506261 GO_REF:0000024 NCBI chr18:46,205,846...46,343,932
Ensembl chr18:46,207,152...46,343,929
JBrowse link
G Sncb synuclein, beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1277151 (MGI:3057254|PMID:15465911)
Ensembl
RGD
PMID:15465911 GO_REF:0000107 MGI:3057254 NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012
JBrowse link
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:3722569 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678
JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:20097214 RGD:6903884 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:20097214 RGD:6903884 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP RGD PMID:12438507 RGD:704388 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:19818757 RGD:5143981 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dao D-amino-acid oxidase involved_in ISO
IEA
(PMID:17303072)
GO_REF:0000107
RGD
Ensembl
PMID:17303072 GO_REF:0000107 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Ddc dopa decarboxylase involved_in IDA
IEA
GO_REF:0000041 UniProt PMID:12703659 GO_REF:0000041, RGD:4139893 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) RGD PMID:16338639 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO MGI:3027995 (MGI:3046856|PMID:15218106) RGD PMID:15218106 MGI:3046856 NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2429971 (MGI:1203924|PMID:9608532), (MGI:3767764|PMID:16782508)
Ensembl
RGD
PMID:9608532 PMID:16782508 GO_REF:0000107 MGI:1203924 MGI:3767764 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO MGI:2386303 (MGI:2386819|PMID:9520487) RGD PMID:9520487 MGI:2386819 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:1888382 (MGI:1352916|PMID:10707987) RGD PMID:10707987 MGI:1352916 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3622848|PMID:16257223)
UniProt
RGD
PMID:16257223 GO_REF:0000024 MGI:3622848 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in
IDA
ISO
IMP
IBA
MGI:1860450 (MGI:2386819|PMID:9520487), (MGI:72094|PMID:7715703), (MGI:77787|PMID:7592982)
PMID:11943812
PMID:21873635
RGD PMID:7592982 PMID:7715703 PMID:9520487 PMID:2427363 PMID:11943812 More... MGI:2386819 MGI:72094 MGI:77787, RGD:1580046, RGD:5129111, RGD:13792537, RGD:5130972 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
dopamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO (MGI:2386819|PMID:9520487) RGD PMID:9520487 MGI:2386819 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
ISS
(PMID:3443096), (PMID:7961964)
(MGI:5787847|PMID:27148966), (MGI:72180|PMID:7715704)
MGI:1857556 (MGI:1332340|PMID:10051631)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:3443096 PMID:7715704 PMID:7961964 PMID:10051631 PMID:27148966 More... GO_REF:0000024 GO_REF:0000107 MGI:1332340 MGI:5787847 MGI:72180, RGD:13792537 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Maoa monoamine oxidase A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2386819|PMID:9520487)
Ensembl
RGD
PMID:9520487 GO_REF:0000107 MGI:2386819 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:21,075,124...21,165,348
Ensembl chr 1:21,075,122...21,161,779
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,724,693...69,733,188
Ensembl chr 4:69,724,239...69,733,299
JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO MGI:2386303 (MGI:2386819|PMID:9520487) RGD PMID:9520487 MGI:2386819 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
negative regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15190105 RGD:2289786 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:17018023 RGD:1625003 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:3814938|PMID:18981141) RGD PMID:18981141 MGI:3814938 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Snca synuclein alpha involved_in IMP PMID:11943812 BHF-UCL PMID:11943812 RGD:5129111 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19703902)
GO_REF:0000107
ParkinsonsUK-UCL
RGD
Ensembl
PMID:19703902 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (MGI:5694519|PMID:26203154) RGD PMID:26203154 MGI:5694519 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618
JBrowse link
positive regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:11239920 RGD:10047061 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO MGI:3027995 (MGI:3046856|PMID:15218106) RGD PMID:15218106 MGI:3046856 NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in ISO (PMID:8643611) RGD PMID:8643611 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Maob monoamine oxidase B IMP RGD PMID:12175458 RGD:2316765 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Npy neuropeptide Y IDA RGD PMID:19579268 RGD:10448966 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3618656|PMID:11282258) RGD PMID:11282258 MGI:3618656 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857158 (MGI:2136539|PMID:11438590)
Ensembl
RGD
PMID:11438590 GO_REF:0000107 MGI:2136539 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd4 dopamine receptor D4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2178631 (MGI:1097029|PMID:9323127)
Ensembl
RGD
PMID:9323127 GO_REF:0000107 MGI:1097029 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A involved_in ISS
ISO
GO_REF:0000024
(MGI:1927024|PMID:11080193)
UniProt
RGD
PMID:11080193 GO_REF:0000024 MGI:1927024 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2671567|PMID:12915123)
Ensembl
RGD
PMID:12915123 GO_REF:0000107 MGI:2671567 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Pde1b phosphodiesterase 1B acts_upstream_of_or_within ISO MGI:3604470 (MGI:3769297|PMID:17559891) RGD PMID:17559891 MGI:3769297 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing acts_upstream_of_or_within ISO MGI:5006973 (MGI:5466578|PMID:22214848) RGD PMID:22214848 MGI:5466578 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:22314364) RGD PMID:22314364 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO MGI:2386303 (MGI:2386819|PMID:9520487), (MGI:894559|PMID:9247269) RGD PMID:9247269 PMID:9520487 MGI:2386819 MGI:894559 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Tacr3 tachykinin receptor 3 IDA RGD PMID:8574643 RGD:2305963 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      cellular metabolic process 10718
        cellular nitrogen compound metabolic process 6561
          cellular amine metabolic process 117
            cellular biogenic amine metabolic process 104
              catecholamine metabolic process 62
                dopamine metabolic process 46
                  dopamine biosynthetic process + 16
                  dopamine catabolic process 6
                  negative regulation of dopamine metabolic process + 4
                  positive regulation of dopamine metabolic process + 8
                  regulation of dopamine metabolic process + 22
Path 2
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      organic substance metabolic process 11338
        organonitrogen compound metabolic process 6803
          amine metabolic process 125
            cellular amine metabolic process 117
              cellular biogenic amine metabolic process 104
                catecholamine metabolic process 62
                  dopamine metabolic process 46
                    dopamine biosynthetic process + 16
                    dopamine catabolic process 6
                    negative regulation of dopamine metabolic process + 4
                    positive regulation of dopamine metabolic process + 8
                    regulation of dopamine metabolic process + 22
paths to the root