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ONTOLOGY REPORT - ANNOTATIONS


Term:norepinephrine metabolic process
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Accession:GO:0042415 term browser browse the term
Definition:The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol metabolic process;   levarterenol metabolism;   noradrenaline metabolic process;   noradrenaline metabolism;   norepinephrine metabolism


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norepinephrine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B ISO RGD PMID:10424772 RGD:8548769 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G Atp7a ATPase copper transporting alpha ISO (MGI:MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:MGI:53851, MGI:MGI:71923 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO (MGI:MGI:1313089|PMID:9808618) MGI PMID:9808618 MGI:MGI:1313089 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Ly6e lymphocyte antigen 6 family member E ISO (MGI:MGI:2157257|PMID:11784869) MGI PMID:11784869 MGI:MGI:2157257 NCBI chrNW_004936470:8,879,217...8,880,777 JBrowse link
G Pnmt phenylethanolamine N-methyltransferase ISO RGD PMID:3945626 RGD:5130757 NCBI chrNW_004936490:14,858,682...14,861,614 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (MGI:MGI:3047192|PMID:15249681) MGI PMID:15249681 MGI:MGI:3047192 NCBI chrNW_004936489:12,118,538...12,913,664 JBrowse link
G Rnf180 ring finger protein 180 ISO (MGI:MGI:5505713|PMID:23926250) MGI PMID:23926250 MGI:MGI:5505713 NCBI chrNW_004936480:4,809,103...4,834,977 JBrowse link
G Rtl4 retrotransposon Gag like 4 ISO (MGI:MGI:5749620|PMID:26402067) MGI PMID:26402067 MGI:MGI:5749620 NCBI chrNW_004936499:2,901,534...2,904,565 JBrowse link
G Spr sepiapterin reductase ISO (MGI:MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:MGI:3722569 NCBI chrNW_004936491:16,693,940...16,699,040 JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO (MGI:MGI:53801|PMID:4405722)
(MGI:MGI:53940|PMID:4858102)
MGI PMID:4405722, PMID:4858102 MGI:MGI:53801, MGI:MGI:53940 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Dbh dopamine beta-hydroxylase ISO (MGI:MGI:5787847|PMID:27148966), (MGI:MGI:72180|PMID:7715704)
(MGI:MGI:1203930|PMID:9603211), (MGI:MGI:1332340|PMID:10051631)
(PMID:27148966)
UniProtKB
MGI
RGD
PMID:7715704, PMID:9603211, PMID:10051631, PMID:10573542, PMID:27148966 MGI:MGI:1203930, MGI:MGI:1332340, MGI:MGI:5787847, MGI:MGI:72180, RGD:1625403 NCBI chrNW_004936669:3,302,014...3,326,233 JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chrNW_004936508:5,855,748...5,938,879 JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:MGI:1859081|PMID:10835639) MGI PMID:10835639 MGI:MGI:1859081 NCBI chrNW_004936484:6,780,692...6,800,883 JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3772428|PMID:18094025) UniProtKB PMID:18094025 MGI:MGI:3772428 NCBI chrNW_004936485:66,889...69,792 JBrowse link
G Kl klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chrNW_004936472:27,604,681...27,649,613 JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chrNW_004936794:478,651...486,887 JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 ISO (MGI:MGI:4413411|PMID:19008477) BHF-UCL PMID:19008477 MGI:MGI:4413411 NCBI chrNW_004936516:4,692,926...4,695,625 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    metabolic process 7668
      nitrogen compound metabolic process 6472
        organonitrogen compound metabolic process 4497
          catecholamine metabolic process 50
            norepinephrine metabolic process 15
              norepinephrine biosynthetic process + 8
              norepinephrine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 11998
    metabolic process 7668
      cellular metabolic process 7073
        cellular aromatic compound metabolic process 3755
          phenol-containing compound metabolic process 102
            catechol-containing compound metabolic process 50
              catecholamine metabolic process 50
                norepinephrine metabolic process 15
                  norepinephrine biosynthetic process + 8
                  norepinephrine catabolic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.