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ONTOLOGY REPORT - ANNOTATIONS

Term:thyroid hormone metabolic process
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Accession:GO:0042403 term browser browse the term
Definition:The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
Synonyms:exact_synonym: thyroid hormone metabolism


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thyroid hormone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRYM crystallin mu involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:17264173) Ensembl
MGI
GO_Central		 PMID:17264173 GO_REF:0000033 GO_REF:0000107 NCBI chr16:21,258,521...21,303,062
Ensembl chr16:21,238,874...21,303,083 		JBrowse link
G DIO1 iodothyronine deiodinase 1 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086 		JBrowse link
G DIO2 iodothyronine deiodinase 2 involved_in ISO
IBA
IEA
IDA		 (PMID:19651899) RGD
GO_Central
TreeGrafter
Ensembl
UniProt		 PMID:15550511 PMID:19651899 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1626436 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757 		JBrowse link
G DIO3 iodothyronine deiodinase 3 involved_in TAS
IEA
IBA
IGI		 (PMID:26305885) Reactome
TreeGrafter
GO_Central
ARUK-UCL		 PMID:26305885 GO_REF:0000033 GO_REF:0000118 Reactome:R-HSA-350864 NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452 		JBrowse link
G DUOX2 dual oxidase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17440044) Ensembl
MGI		 PMID:17440044 GO_REF:0000107 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172 		JBrowse link
G GCNT4 glucosaminyl (N-acetyl) transferase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19349303) Ensembl
MGI		 PMID:19349303 GO_REF:0000107 NCBI chr 5:75,016,969...75,054,060
Ensembl chr 5:75,025,346...75,052,558 		JBrowse link
G IYD iodotyrosine deiodinase involved_in IDA
IEA
IBA		 (PMID:25395621) UniProt
TreeGrafter
GO_Central		 PMID:25395621 GO_REF:0000033 GO_REF:0000118 NCBI chr 6:150,369,012...150,405,969
Ensembl chr 6:150,368,892...150,405,969 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 acts_upstream_of_or_within ISO MGI MGI:85368 NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345 		JBrowse link
G RELN reelin acts_upstream_of_or_within ISO MGI MGI:85368 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658 		JBrowse link
G SLC16A2 solute carrier family 16 member 2 acts_upstream_of IGI (PMID:26305885) ARUK-UCL PMID:26305885 NCBI chr  X:74,421,493...74,533,916
Ensembl chr  X:74,421,493...74,533,917 		JBrowse link
G SLCO4A1 solute carrier organic anion transporter family member 4A1 ISO RGD PMID:11316767 RGD:727314 NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785 		JBrowse link
G SULT1B1 sulfotransferase family 1B member 1 involved_in IDA
IEA		 (PMID:9443824), (PMID:9463486) UniProt
Ensembl		 PMID:9443824 PMID:9463486 GO_REF:0000107 NCBI chr 4:69,721,167...69,760,620
Ensembl chr 4:69,721,167...69,787,961 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 involved_in IDA (PMID:10199779) UniProt PMID:10199779 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G TG thyroglobulin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:3803305) Ensembl
MGI		 PMID:3803305 GO_REF:0000107 NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903 		JBrowse link
positive regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNS cystinosin, lysosomal cystine transporter involved_in ISO
IEA		 RGD
Ensembl		 PMID:35695380 GO_REF:0000107 RGD:155630629 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103 		JBrowse link
G GATA3 GATA binding protein 3 involved_in IMP (PMID:19248180), (PMID:19723756) UniProt PMID:19248180 PMID:19723756 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G HPN hepsin involved_in ISS UniProt GO_REF:0000024 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573 		JBrowse link
G PAX8 paired box 8 involved_in IEA
IMP		 (PMID:15356023) Ensembl
UniProt		 PMID:15356023 GO_REF:0000107 NCBI chr 2:113,215,997...113,278,921
Ensembl chr 2:113,215,997...113,278,921 		JBrowse link
G SLCO1C1 solute carrier organic anion transporter family member 1C1 involved_in IMP (PMID:18566113) ARUK-UCL PMID:18566113 NCBI chr12:20,695,332...20,753,386
Ensembl chr12:20,695,332...20,753,386 		JBrowse link
regulation of thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOXA1 dual oxidase maturation factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22301785) Ensembl
MGI		 PMID:22301785 GO_REF:0000107 NCBI chr15:45,117,366...45,129,879
Ensembl chr15:45,117,366...45,129,938 		JBrowse link
G DUOXA2 dual oxidase maturation factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22301785) Ensembl
MGI		 PMID:22301785 GO_REF:0000107 NCBI chr15:45,114,326...45,118,421
Ensembl chr15:45,114,326...45,118,421 		JBrowse link
thyroid hormone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DIO2 iodothyronine deiodinase 2 acts_upstream_of_or_within ISO (PMID:11731615) MGI PMID:11731615 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757 		JBrowse link
G DIO3 iodothyronine deiodinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20203194), (PMID:25002520)
(PMID:16410833)		 Ensembl
MGI		 PMID:16410833 PMID:20203194 PMID:25002520 GO_REF:0000107 NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452 		JBrowse link
thyroid hormone generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGA glycoprotein hormones, alpha polypeptide involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:12114718) Ensembl
MGI
GO_Central
TreeGrafter		 PMID:12114718 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:87,085,498...87,095,106
Ensembl chr 6:87,085,498...87,095,106 		JBrowse link
G CPQ carboxypeptidase Q involved_in IEA
IBA
ISS		 Ensembl
GO_Central
TreeGrafter
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:96,645,242...97,143,501
Ensembl chr 8:96,645,242...97,149,654 		JBrowse link
G CTSB cathepsin B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CTSK cathepsin K involved_in IEA
IDA		 (PMID:11082042) Ensembl
UniProt		 PMID:11082042 GO_REF:0000107 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CTSL cathepsin L involved_in ISO (MGI:2664014|PMID:12782676) UniProt PMID:12782676 MGI:2664014 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469 		JBrowse link
G DIO1 iodothyronine deiodinase 1 involved_in TAS (PMID:1400883) PINC PMID:1400883 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086 		JBrowse link
G DIO2 iodothyronine deiodinase 2 involved_in ISO
IEA
TAS		 (PMID:8755651), (PMID:9837913) RGD
Ensembl
PINC		 PMID:8755651 PMID:9837913 PMID:15550511 GO_REF:0000107 RGD:1626436 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757 		JBrowse link
G DUOX1 dual oxidase 1 involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000041 Reactome:R-HSA-209968 NCBI chr15:45,129,994...45,165,574
Ensembl chr15:45,129,933...45,165,576 		JBrowse link
G DUOX2 dual oxidase 2 involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000041 Reactome:R-HSA-209968 NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172 		JBrowse link
G FOXE1 forkhead box E1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:9697704) UniProt
MGI
Ensembl		 PMID:9697704 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:97,853,226...97,856,717
Ensembl chr 9:97,853,226...97,856,717 		JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10882104) Ensembl
MGI		 PMID:10882104 GO_REF:0000107 NCBI chr17:39,404,285...39,451,263
Ensembl chr17:39,404,285...39,451,272 		JBrowse link
G SLC16A10 solute carrier family 16 member 10 involved_in
acts_upstream_of_or_within_negative_effect		 IEA
ISO		 (PMID:24248460) Ensembl
MGI		 PMID:24248460 GO_REF:0000107 NCBI chr 6:111,087,503...111,231,194
Ensembl chr 6:111,087,503...111,231,194 		JBrowse link
G SLC16A2 solute carrier family 16 member 2 involved_in
acts_upstream_of_or_within_negative_effect		 IEA
ISO		 (PMID:24248460) Ensembl
MGI		 PMID:24248460 GO_REF:0000107 NCBI chr  X:74,421,493...74,533,916
Ensembl chr  X:74,421,493...74,533,917 		JBrowse link
G SLC26A7 solute carrier family 26 member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:91,209,496...91,398,155
Ensembl chr 8:91,209,494...91,398,155 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 involved_in TAS
IEA		 Reactome
InterPro		 GO_REF:0000002 Reactome:R-HSA-209968 NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174 		JBrowse link
G TG thyroglobulin involved_in ISO
IBA
IEA
ISS
IDA		 (PMID:32025030) RGD
GO_Central
TreeGrafter
UniProt
Ensembl		 PMID:3953233 PMID:32025030 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1600150 NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903 		JBrowse link
G TPO thyroid peroxidase involved_in IEA
TAS
NAS		 (PMID:1401057) InterPro
Reactome
UniProt		 PMID:1401057 GO_REF:0000002 GO_REF:0000041 Reactome:R-HSA-209968 NCBI chr 2:1,374,047...1,543,673
Ensembl chr 2:1,374,066...1,543,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      hormone metabolic process 271
        thyroid hormone metabolic process 33
          thyroid hormone catabolic process 2
          thyroid hormone generation + 24
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organic cyclic compound metabolic process 7069
          phenol-containing compound metabolic process 143
            thyroid hormone metabolic process 33
              thyroid hormone catabolic process 2
              thyroid hormone generation + 24
paths to the root