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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin K metabolic process
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Accession:GO:0042373 term browser browse the term
Definition:The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
Synonyms:exact_synonym: vitamin K metabolism
 broad_synonym: naphthoquinone metabolic process;   naphthoquinone metabolism


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vitamin K metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC135050.2 novel protein, VKORC1 and PRSS53 readthrough involved_in IEA InterPro GO_REF:0000002 Ensembl chr16:31,083,439...31,094,956 JBrowse link
G AIFM2 AIF family member 2 involved_in IDA (PMID:35922516) UniProt PMID:35922516 NCBI chr10:70,112,271...70,132,825
Ensembl chr10:70,098,223...70,132,934 		JBrowse link
G CBR1 carbonyl reductase 1 involved_in IDA (PMID:18449627) UniProt PMID:18449627 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G GGCX gamma-glutamyl carboxylase involved_in IDA (PMID:17073445) UniProt PMID:17073445 NCBI chr 2:85,544,720...85,561,493
Ensembl chr 2:85,544,720...85,561,532 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in IDA
IEA		 (PMID:8999809) UniProt
Ensembl		 PMID:8999809 GO_REF:0000107 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G UBIAD1 UbiA prenyltransferase domain containing 1 involved_in TAS Reactome Reactome:R-HSA-6806664 NCBI chr 1:11,273,198...11,299,574
Ensembl chr 1:11,273,198...11,296,049 		JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA		 (PMID:15879509)
(PMID:16270630), (PMID:33154105)		 InterPro
MGI
GO_Central
UniProt
Ensembl		 PMID:15879509 PMID:16270630 PMID:33154105 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980 		JBrowse link
G VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 involved_in IEA
IBA
TAS
IDA		 (PMID:21367861) Ensembl
GO_Central
Reactome
UniProt
InterPro		 PMID:21367861 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 Reactome:R-HSA-6806664 NCBI chr 7:65,865,772...65,959,558
Ensembl chr 7:65,873,074...65,959,563 		JBrowse link
phylloquinone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR1 carbonyl reductase 1 ISO menadione catabolism RGD PMID:16359670 RGD:2316273 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CBR3 carbonyl reductase 3 involved_in ISO
IEA		 menadione catabolism RGD
Ensembl		 PMID:18983987 GO_REF:0000107 RGD:2316293 NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562 		JBrowse link
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in IDA
IBA
IEA		 (PMID:24138531) UniProt
GO_Central		 PMID:24138531 GO_REF:0000033 GO_REF:0000041 NCBI chr19:15,912,377...15,934,867
Ensembl chr19:15,912,367...15,934,867 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:15,673,087...15,697,174
Ensembl chr19:15,673,018...15,697,174 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IEA
IDA		 (PMID:24138531) UniProt PMID:24138531 GO_REF:0000041 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077 		JBrowse link
vitamin K biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBIAD1 UbiA prenyltransferase domain containing 1 involved_in IDA
IBA
IMP		 (PMID:20953171)
(PMID:23169578)		 UniProt
GO_Central		 PMID:20953171 PMID:23169578 GO_REF:0000033 NCBI chr 1:11,273,198...11,299,574
Ensembl chr 1:11,273,198...11,296,049 		JBrowse link
vitamin K catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in IDA (PMID:24138531) UniProt PMID:24138531 NCBI chr19:15,912,377...15,934,867
Ensembl chr19:15,912,367...15,934,867 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IDA (PMID:19297519), (PMID:24138531) UniProt PMID:19297519 PMID:24138531 NCBI chr19:15,878,023...15,898,074
Ensembl chr19:15,878,023...15,898,077 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19789
    cellular process 18958
      metabolic process 13083
        ketone metabolic process 258
          vitamin K metabolic process 12
            phylloquinone metabolic process + 5
            vitamin K biosynthetic process + 1
            vitamin K catabolic process + 5
Path 2
Term Annotations click to browse term
  biological_process 19789
    cellular process 18958
      metabolic process 13083
        small molecule metabolic process 1990
          vitamin metabolic process 132
            fat-soluble vitamin metabolic process 54
              vitamin K metabolic process 12
                phylloquinone metabolic process + 5
                vitamin K biosynthetic process + 1
                vitamin K catabolic process + 5
paths to the root