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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin K metabolic process
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Accession:GO:0042373 term browser browse the term
Definition:The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
Synonyms:exact_synonym: vitamin K metabolism
 broad_synonym: naphthoquinone metabolic process;   naphthoquinone metabolism

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vitamin K metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM2 AIF family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:61,174,125...61,197,848
Ensembl chr 9:61,182,826...61,195,769 		JBrowse link
G CBR1 carbonyl reductase 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 2:80,096,955...80,102,721 JBrowse link
G GGCX gamma-glutamyl carboxylase involved_in ISO (PMID:17073445) UniProt PMID:17073445 NCBI chr14:21,593,202...21,605,800
Ensembl chr14:21,593,088...21,604,885 		JBrowse link
G LOC103218526 carbonyl reductase [NADPH] 1 involved_in ISO (PMID:18449627) UniProt PMID:18449627 NCBI chr 2:80,096,743...80,099,982 JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:57,676,547...57,695,434
Ensembl chr 5:57,675,981...57,716,599 		JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15879509) InterPro
TreeGrafter
MGI		 PMID:15879509 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:27,778,553...27,782,639
Ensembl chr 5:27,776,416...27,782,640 		JBrowse link
G VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 involved_in ISO (MGI:5559651|PMID:23928358)
(PMID:21367861)		 UniProt PMID:21367861 PMID:23928358 MGI:5559651 RGD:8553362 NCBI chr28:1,535,346...1,617,484 JBrowse link
G VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 Ensembl chr28:1,535,329...1,706,948 JBrowse link
phylloquinone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR3 carbonyl reductase 3 ISO menadione catabolism RGD PMID:18983987 RGD:2316293 NCBI chr 2:80,158,842...80,164,208
Ensembl chr 2:80,158,806...80,164,248 		JBrowse link
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,460,588...14,482,294
Ensembl chr 6:14,426,592...14,481,523 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,295,911...14,317,353
Ensembl chr 6:14,296,417...14,317,289 		JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,241,352...14,260,799
Ensembl chr 6:14,241,409...14,263,494 		JBrowse link
G CYP4F57 cytochrome P450 family 4 subfamily F member 57 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,266,404...14,289,290
Ensembl chr 6:14,267,401...14,288,474 		JBrowse link
G CYP4F8 cytochrome P450 family 4 subfamily F member 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,211,899...14,229,793
Ensembl chr 6:14,215,337...14,229,509 		JBrowse link
G LOC103234089 cytochrome P450 4F2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:14,426,588...14,447,276 JBrowse link
vitamin K biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBIAD1 UbiA prenyltransferase domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:120,499,210...120,512,759
Ensembl chr20:120,496,075...120,512,748 		JBrowse link
vitamin K catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in ISO (PMID:24138531) UniProt PMID:24138531 NCBI chr 6:14,460,588...14,482,294
Ensembl chr 6:14,426,592...14,481,523 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17106
    cellular process 16633
      metabolic process 11190
        ketone metabolic process 239
          vitamin K metabolic process 16
            phylloquinone metabolic process + 7
            vitamin K biosynthetic process + 1
            vitamin K catabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 17106
    cellular process 16633
      metabolic process 11190
        small molecule metabolic process 1706
          vitamin metabolic process 99
            fat-soluble vitamin metabolic process 47
              vitamin K metabolic process 16
                phylloquinone metabolic process + 7
                vitamin K biosynthetic process + 1
                vitamin K catabolic process + 7
paths to the root