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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin K metabolic process
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Accession:GO:0042373 term browser browse the term
Definition:The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.
Synonyms:exact_synonym: vitamin K metabolism
 broad_synonym: naphthoquinone metabolic process;   naphthoquinone metabolism


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vitamin K metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM2 AIF family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:66,529,411...66,621,122
Ensembl chr10:69,114,194...69,135,267 		JBrowse link
G CBR1 carbonyl reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:22,440,726...22,443,950
Ensembl chr21:35,800,177...35,803,458 		JBrowse link
G GGCX gamma-glutamyl carboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:85,599,227...85,612,274
Ensembl chr2A:87,152,111...87,164,567 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15879509) InterPro
TreeGrafter
MGI
Ensembl		 PMID:15879509 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr16:23,871,756...23,876,599
Ensembl chr16:31,459,560...31,464,897 		JBrowse link
G VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 involved_in ISO (PMID:21367861)
PMID:23928358
(MGI:5559651|PMID:23928358)		 UniProt PMID:21367861 PMID:23928358 MGI:5559651 RGD:8553362 NCBI chr 7:60,111,428...60,196,412 JBrowse link
phylloquinone catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBR3 carbonyl reductase 3 ISO menadione catabolism RGD PMID:18983987 RGD:2316293 NCBI chr21:22,505,647...22,516,938
Ensembl chr21:35,865,374...35,876,717 		JBrowse link
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:15,403,595...15,422,428
Ensembl chr19:16,383,898...16,402,720 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:15,195,240...15,216,325
Ensembl chr19:16,178,495...16,199,477 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:15,367,328...15,388,139
Ensembl chr19:16,349,577...16,368,520 		JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:15,162,886...15,182,334
Ensembl chr19:16,146,664...16,165,869 		JBrowse link
G CYP4F8 cytochrome P450 family 4 subfamily F member 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:15,134,029...15,150,378
Ensembl chr19:16,118,830...16,133,182 		JBrowse link
G LOC100967757 cytochrome P450 4F12-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:15,276,790...15,298,497 JBrowse link
vitamin K biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBIAD1 UbiA prenyltransferase domain containing 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:10,039,415...10,161,005
Ensembl chr 1:11,260,412...11,281,381 		JBrowse link
vitamin K catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:15,403,595...15,422,428
Ensembl chr19:16,383,898...16,402,720 		JBrowse link
G CYP4F2 cytochrome P450 family 4 subfamily F member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:15,367,328...15,388,139
Ensembl chr19:16,349,577...16,368,520 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16786
    cellular process 16372
      metabolic process 11065
        ketone metabolic process 227
          vitamin K metabolic process 14
            phylloquinone metabolic process + 7
            vitamin K biosynthetic process + 1
            vitamin K catabolic process + 7
Path 2
Term Annotations click to browse term
  biological_process 16786
    cellular process 16372
      metabolic process 11065
        small molecule metabolic process 1682
          vitamin metabolic process 99
            fat-soluble vitamin metabolic process 45
              vitamin K metabolic process 14
                phylloquinone metabolic process + 7
                vitamin K biosynthetic process + 1
                vitamin K catabolic process + 7
paths to the root