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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin D biosynthetic process
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Accession:GO:0042368 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D anabolism;   vitamin D biosynthesis;   vitamin D formation;   vitamin D synthesis
 narrow_synonym: calciferol biosynthesis;   calciferol biosynthetic process;   cholecalciferol biosynthesis;   cholecalciferol biosynthetic process;   ergocalciferol biosynthesis;   ergocalciferol biosynthetic process


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vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr11:14,877,440...14,892,443
Ensembl chr11:14,877,440...14,892,231 		JBrowse link
calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IDA
IEA
IBA		 (PMID:15465040) UniProt
GO_Central		 PMID:15465040 GO_REF:0000033 GO_REF:0000117 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA
IBA
IDA		 (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400) Ensembl
UniProt
GO_Central
BHF-UCL		 PMID:9415400 PMID:15795327 PMID:16549446 PMID:17023519 PMID:22862690 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in IDA (PMID:15465040), (PMID:18511070) UniProt PMID:15465040 PMID:18511070 NCBI chr11:14,877,440...14,892,443
Ensembl chr11:14,877,440...14,892,231 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor involved_in IC (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in IC (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IDA (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IDA (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740 		JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IDA (PMID:9282826) BHF-UCL PMID:9282826 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G TNF tumor necrosis factor involved_in IDA (PMID:1690216) BHF-UCL PMID:1690216 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organic substance biosynthetic process 9224
          organic hydroxy compound biosynthetic process 280
            vitamin D biosynthetic process 10
              calcitriol biosynthetic process from calciol 4
              negative regulation of vitamin D biosynthetic process + 4
              positive regulation of vitamin D biosynthetic process 2
              regulation of vitamin D biosynthetic process + 6
              vitamin D3 biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      primary metabolic process 10695
        lipid metabolic process 1530
          steroid metabolic process 375
            steroid biosynthetic process 211
              vitamin D biosynthetic process 10
                calcitriol biosynthetic process from calciol 4
                negative regulation of vitamin D biosynthetic process + 4
                positive regulation of vitamin D biosynthetic process 2
                regulation of vitamin D biosynthetic process + 6
                vitamin D3 biosynthetic process 0
paths to the root