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ONTOLOGY REPORT - ANNOTATIONS


Term:vitamin D biosynthetic process
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Accession:GO:0042368 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D anabolism;   vitamin D biosynthesis;   vitamin D formation;   vitamin D synthesis
 narrow_synonym: calciferol biosynthesis;   calciferol biosynthetic process;   cholecalciferol biosynthesis;   cholecalciferol biosynthetic process;   ergocalciferol biosynthesis;   ergocalciferol biosynthetic process



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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in ISO (PMID:15465040) UniProt PMID:15465040 NCBI chr37:25,366,475...25,401,978
Ensembl chr37:25,366,472...25,401,509
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
(MGI:3590419|PMID:15972816)
BHF-UCL
UniProt
PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 More... MGI:3590419 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:37,553,883...37,579,744
Ensembl chr21:37,552,732...37,606,725
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:56,473,032...56,484,422
Ensembl chr 6:56,256,305...56,484,422
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAI1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) BHF-UCL PMID:19502595 NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653
JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13874
    metabolic process 8976
      organic substance metabolic process 8624
        organic substance biosynthetic process 4459
          organic hydroxy compound biosynthetic process 198
            vitamin D biosynthetic process 9
              calcitriol biosynthetic process from calciol 3
              negative regulation of vitamin D biosynthetic process + 5
              positive regulation of vitamin D biosynthetic process 2
              regulation of vitamin D biosynthetic process + 7
              vitamin D3 biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 13874
    metabolic process 8976
      primary metabolic process 7894
        lipid metabolic process 1096
          steroid metabolic process 256
            steroid biosynthetic process 133
              vitamin D biosynthetic process 9
                calcitriol biosynthetic process from calciol 3
                negative regulation of vitamin D biosynthetic process + 5
                positive regulation of vitamin D biosynthetic process 2
                regulation of vitamin D biosynthetic process + 7
                vitamin D3 biosynthetic process 0
paths to the root