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ONTOLOGY REPORT - ANNOTATIONS


Term:vitamin D biosynthetic process
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Accession:GO:0042368 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D anabolism;   vitamin D biosynthesis;   vitamin D formation;   vitamin D synthesis
 narrow_synonym: calciferol biosynthesis;   calciferol biosynthetic process;   cholecalciferol biosynthesis;   cholecalciferol biosynthetic process;   ergocalciferol biosynthesis;   ergocalciferol biosynthetic process


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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102004889 sterol 26-hydroxylase, mitochondrial involved_in ISO (PMID:15465040) UniProt PMID:15465040 NCBI chrNW_004955453:14,601,495...14,647,383
Ensembl chrNW_004955453:14,601,444...14,647,366
JBrowse link
G LOC102011841 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in ISO (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
(MGI:3590419|PMID:15972816)
BHF-UCL
UniProt
PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 More... MGI:3590419 NCBI chrNW_004955458:5,472,404...5,477,001
Ensembl chrNW_004955458:5,472,404...5,477,001
JBrowse link
G LOC102024786 vitamin D 25-hydroxylase involved_in ISO (PMID:15465040), (PMID:18511070) UniProt PMID:15465040 PMID:18511070 NCBI chrNW_004955414:29,929,130...29,948,151
Ensembl chrNW_004955414:29,928,644...29,948,484
JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) BHF-UCL PMID:15947108 NCBI chrNW_004955423:2,024,084...2,032,530
Ensembl chrNW_004955423:2,022,417...2,033,149
JBrowse link
G LOC102011841 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chrNW_004955458:5,472,404...5,477,001
Ensembl chrNW_004955458:5,472,404...5,477,001
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chrNW_004955496:5,842,734...5,950,995
Ensembl chrNW_004955496:5,842,600...5,927,885
JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) BHF-UCL PMID:19502595 NCBI chrNW_004955445:8,232,084...8,237,893
Ensembl chrNW_004955445:8,231,924...8,237,996
JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) BHF-UCL PMID:18485278 PMID:19502595 NCBI chrNW_004955454:8,759,860...8,763,603
Ensembl chrNW_004955454:8,758,636...8,764,427
JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:9282826) BHF-UCL PMID:9282826 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:1690216) BHF-UCL PMID:1690216 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11982
    metabolic process 7566
      organic substance metabolic process 7296
        organic substance biosynthetic process 3826
          organic hydroxy compound biosynthetic process 176
            vitamin D biosynthetic process 9
              calcitriol biosynthetic process from calciol 3
              negative regulation of vitamin D biosynthetic process + 5
              positive regulation of vitamin D biosynthetic process 2
              regulation of vitamin D biosynthetic process + 7
              vitamin D3 biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 11982
    metabolic process 7566
      primary metabolic process 6686
        lipid metabolic process 942
          steroid metabolic process 220
            steroid biosynthetic process 117
              vitamin D biosynthetic process 9
                calcitriol biosynthetic process from calciol 3
                negative regulation of vitamin D biosynthetic process + 5
                positive regulation of vitamin D biosynthetic process 2
                regulation of vitamin D biosynthetic process + 7
                vitamin D3 biosynthetic process 0
paths to the root