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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin D metabolic process
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Accession:GO:0042359 term browser browse the term
Definition:The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D metabolism
 narrow_synonym: calciferol metabolic process;   calciferol metabolism;   cholecalciferol metabolic process;   cholecalciferol metabolism;   ergocalciferol metabolic process;   ergocalciferol metabolism

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vitamin D metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf23 fibroblast growth factor 23 ISO RGD PMID:15531762 RGD:1598934 NCBI chrNW_004936606:4,555,034...4,561,961
Ensembl chrNW_004936606:4,555,034...4,561,961 		JBrowse link
G Gc GC vitamin D binding protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15225763) Ensembl
MGI		 PMID:15225763 GO_REF:0000107 NCBI chrNW_004936598:3,220,029...3,256,091
Ensembl chrNW_004936598:3,219,991...3,261,629 		JBrowse link
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15225763) RGD
MGI
Ensembl		 PMID:1991512 PMID:15225763 GO_REF:0000107 RGD:1298844 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185 		JBrowse link
G LOC101972957 vitamin D 25-hydroxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12867411) Ensembl
MGI		 PMID:12867411 GO_REF:0000107 NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302 		JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10052453) Ensembl
MGI		 PMID:10052453 GO_REF:0000107 NCBI chrNW_004936469:10,245,001...10,438,933
Ensembl chrNW_004936469:10,244,881...10,438,935 		JBrowse link
calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101963150 sterol 26-hydroxylase, mitochondrial involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004936569:1,213,700...1,250,181
Ensembl chrNW_004936569:1,213,573...1,250,589 		JBrowse link
G LOC101972957 vitamin D 25-hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:3,881,630...3,897,613
Ensembl chrNW_004936528:3,881,087...3,900,302 		JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:4,456,498...4,462,436
Ensembl chrNW_004936514:4,456,484...4,462,987 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936590:3,813,916...3,817,642
Ensembl chrNW_004936590:3,813,888...3,817,642 		JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
vitamin D catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf23 fibroblast growth factor 23 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:4,555,034...4,561,961
Ensembl chrNW_004936606:4,555,034...4,561,961 		JBrowse link
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185 		JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104 		JBrowse link
vitamin D3 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:28798354) MGI PMID:28798354 NCBI chrNW_004937067:194,375...246,607 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259513) Ensembl
MGI		 PMID:24259513 GO_REF:0000107 NCBI chrNW_004936710:1,760,365...1,815,269
Ensembl chrNW_004936710:1,760,089...1,815,508 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (PMID:24259513) MGI PMID:24259513 NCBI chrNW_004936597:1,388,394...1,397,731
Ensembl chrNW_004936597:1,385,624...1,397,758 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      organic substance metabolic process 9204
        organic hydroxy compound metabolic process 521
          vitamin D metabolic process 14
            vitamin D biosynthetic process + 7
            vitamin D catabolic process + 3
            vitamin D2 metabolic process 0
            vitamin D3 metabolic process + 6
            vitamin D4 metabolic process 0
            vitamin D5 metabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      small molecule metabolic process 1637
        vitamin metabolic process 92
          fat-soluble vitamin metabolic process 36
            vitamin D metabolic process 14
              vitamin D biosynthetic process + 7
              vitamin D catabolic process + 3
              vitamin D2 metabolic process 0
              vitamin D3 metabolic process + 6
              vitamin D4 metabolic process 0
              vitamin D5 metabolic process 0
paths to the root