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ONTOLOGY REPORT - ANNOTATIONS

Term:vitamin D metabolic process
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Accession:GO:0042359 term browser browse the term
Definition:The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
Synonyms:exact_synonym: vitamin D metabolism
 narrow_synonym: calciferol metabolic process;   calciferol metabolism;   cholecalciferol metabolic process;   cholecalciferol metabolism;   ergocalciferol metabolic process;   ergocalciferol metabolism
 xref: Reactome:R-HSA-196791 "Vitamin D (calciferol) metabolism"


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vitamin D metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in ISO (PMID:15546903) BHF-UCL PMID:15546903 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15225763) RGD
MGI
Ensembl		 PMID:1991512 PMID:15225763 GO_REF:0000107 RGD:1298844 NCBI chr20:50,500,103...50,520,487
Ensembl chr20:51,721,685...51,742,716 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:9371776 GO_REF:0000107 RGD:69372 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12867411) Ensembl
MGI		 PMID:12867411 GO_REF:0000107 NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in ISO (PMID:15546903) BHF-UCL PMID:15546903 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G FGF23 fibroblast growth factor 23 ISO RGD PMID:15531762 RGD:1598934 NCBI chr12:4,479,116...4,488,797
Ensembl chr12:4,400,802...4,412,000 		JBrowse link
G GC GC vitamin D binding protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15225763) Ensembl
MGI		 PMID:15225763 GO_REF:0000107 NCBI chr 4:52,431,196...52,473,762
Ensembl chr 4:58,729,236...58,792,073 		JBrowse link
G LRP2 LDL receptor related protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10052453) Ensembl
MGI		 PMID:10052453 GO_REF:0000107 NCBI chr2B:56,407,871...56,640,471
Ensembl chr2B:173,873,767...174,103,697 		JBrowse link
calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in ISO (PMID:16549446) BHF-UCL PMID:16549446 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) BHF-UCL PMID:15947108 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) BHF-UCL PMID:15243130 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:46,321,075...46,328,865
Ensembl chr20:47,384,818...47,390,733 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904 		JBrowse link
positive regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
vitamin D catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,500,103...50,520,487
Ensembl chr20:51,721,685...51,742,716 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G FGF23 fibroblast growth factor 23 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:4,479,116...4,488,797
Ensembl chr12:4,400,802...4,412,000 		JBrowse link
vitamin D3 metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:28798354) MGI PMID:28798354 NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259513) Ensembl
MGI		 PMID:24259513 GO_REF:0000107 NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 acts_upstream_of_or_within ISO (PMID:24259513) MGI PMID:24259513 NCBI chr 5:172,386,443...172,400,271
Ensembl chr 5:179,454,995...179,467,605 		JBrowse link
G LOC100975751 UDP-glucuronosyltransferase 1A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:120,900,855...121,028,232
Ensembl chr2B:239,755,364...239,900,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19447
    cellular process 19000
      metabolic process 12941
        primary metabolic process 11364
          lipid metabolic process 1310
            steroid metabolic process 310
              vitamin D metabolic process 19
                vitamin D biosynthetic process + 10
                vitamin D catabolic process + 4
                vitamin D2 metabolic process 0
                vitamin D3 metabolic process + 8
                vitamin D4 metabolic process 0
                vitamin D5 metabolic process 0
paths to the root