Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of natural killer cell mediated cytotoxicity
go back to main search page
Accession:GO:0042269 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
Synonyms:exact_synonym: regulation of NK cell mediated cell death;   regulation of NK cell mediated cell killing;   regulation of natural killer cell mediated cell death;   regulation of natural killer cell mediated cell killing
 related_synonym: regulation of NK cell mediated cytolysis;   regulation of NK cell mediated cytotoxicity;   regulation of natural killer cell mediated cytolysis


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
 
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,953,372...1,983,765 JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) UniProt PMID:23408620 MGI:5491117 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G Clec12b C-type lectin domain family 12 member B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936902:520,825...528,181 JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:18835194 RGD:11568650 NCBI chrNW_004936538:7,581,453...7,609,543 JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:9021955 RGD:9685777 NCBI chrNW_004936694:2,051,362...2,053,812 JBrowse link
G Igf2 insulin like growth factor 2 ISO RGD PMID:9021955 RGD:9685777 NCBI chrNW_004936816:972,902...981,232 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC101955362 natural killer cells antigen CD94 involved_in ISO (PMID:9486650) UniProt PMID:9486650 NCBI chrNW_004936902:302,811...309,379 JBrowse link
G Sh2d1b SH2 domain containing 1B acts_upstream_of_or_within ISO (MGI:3639618|PMID:16127454) MGI PMID:16127454 MGI:3639618 NCBI chrNW_004936831:604,308...635,459 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G LOC101954488 CEA cell adhesion molecule 1 involved_in ISO (PMID:23696226)
(MGI:5512785|PMID:23696226)
UniProt PMID:23696226 MGI:5512785 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G LOC101976242 NKG2-D type II integral membrane protein ISO RGD PMID:12782717 RGD:1299590 NCBI chrNW_004936902:216,495...229,150 JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:21,983,248...22,063,133 JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chrNW_004936867:478,625...485,905 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:377,359...389,121 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:21,983,248...22,063,133 JBrowse link
G Cadm1 cell adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:569,739...883,738 JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:12486241), (PMID:17307798) UniProt PMID:12486241 PMID:17307798 NCBI chrNW_004936867:478,625...485,905 JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
HGNC-UCL
UniProt
PMID:15811952 MGI:3689781 NCBI chrNW_004936542:7,402,879...7,411,510 JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:2204066) UniProt PMID:2204066 NCBI chrNW_004936519:6,166,060...6,180,652 JBrowse link
G Il18rap interleukin 18 receptor accessory protein acts_upstream_of_or_within ISO (MGI:3578455|PMID:15843532) MGI PMID:15843532 MGI:3578455 NCBI chrNW_004936713:1,087,884...1,115,512 JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3028812|PMID:14764669) MGI
Ensembl
PMID:14764669 GO_REF:0000107 MGI:3028812 NCBI chrNW_004936662:1,689,879...1,696,883 JBrowse link
G Lag3 lymphocyte activating 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:80003|PMID:8602528) MGI
Ensembl
PMID:8602528 GO_REF:0000107 MGI:80003 NCBI chrNW_004936709:1,041,519...1,048,630 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:377,359...389,121 JBrowse link
G LOC101954516 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3655409|PMID:9841920) MGI
Ensembl
PMID:9841920 GO_REF:0000107 MGI:3655409 NCBI chrNW_004936490:17,022,268...17,043,751 JBrowse link
G LOC101955362 natural killer cells antigen CD94 involved_in ISO (PMID:9754572) UniProt PMID:9754572 NCBI chrNW_004936902:302,811...309,379 JBrowse link
G LOC101976242 NKG2-D type II integral membrane protein involved_in ISO (PMID:15294961) UniProt PMID:15294961 NCBI chrNW_004936902:216,495...229,150 JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chrNW_004936727:1,921,452...1,924,395 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,470,910...1,498,986 JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chrNW_004936706:1,356,690...1,369,547 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:2,152,231...2,222,260 JBrowse link
G Sh2d1a SH2 domain containing 1A acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3639618|PMID:16127454)
(MGI:4355255|PMID:19648922)
MGI
Ensembl
PMID:16127454 PMID:19648922 GO_REF:0000107 MGI:3639618 MGI:4355255 NCBI chrNW_004936479:6,258,953...6,281,552 JBrowse link
G Sh2d1b SH2 domain containing 1B acts_upstream_of_or_within ISO (MGI:4355255|PMID:19648922)
(MGI:4839659|PMID:20962259)
MGI PMID:19648922 PMID:20962259 MGI:4355255 MGI:4839659 NCBI chrNW_004936831:604,308...635,459 JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:16920955) UniProt PMID:16920955 NCBI chrNW_004936740:155,268...165,536 JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4839659|PMID:20962259) MGI
Ensembl
PMID:20962259 GO_REF:0000107 MGI:4839659 NCBI chrNW_004936588:4,058,312...4,107,330 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
HGNC-UCL
UniProt
PMID:15811952 MGI:3689781 NCBI chrNW_004936542:7,402,879...7,411,510 JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:7903063) UniProt PMID:7903063 NCBI chrNW_004936519:6,166,060...6,180,652 JBrowse link
G Il12b interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936515:4,056,214...4,066,121 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,470,910...1,498,986 JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chrNW_004936706:1,356,690...1,369,547 JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tap1 transporter 1, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chrNW_004936476:25,899,514...25,907,690 JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chrNW_004936476:25,913,699...25,923,419 JBrowse link
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm1 cell adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:569,739...883,738 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,470,910...1,498,986 JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chrNW_004936706:1,356,690...1,369,547 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15040
    regulation of biological process 10217
      regulation of cellular process 9652
        regulation of cell killing 82
          regulation of leukocyte mediated cytotoxicity 62
            regulation of natural killer cell mediated cytotoxicity 33
              negative regulation of natural killer cell mediated cytotoxicity + 13
              positive regulation of natural killer cell mediated cytotoxicity + 21
              regulation of natural killer cell degranulation + 4
              regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 8
Path 2
Term Annotations click to browse term
  biological_process 15040
    response to stimulus 8032
      response to biotic stimulus 1307
        response to external biotic stimulus 1265
          response to other organism 1261
            defense response to other organism 829
              innate immune response 556
                natural killer cell mediated immunity 53
                  regulation of natural killer cell mediated immunity 36
                    regulation of natural killer cell mediated cytotoxicity 33
                      negative regulation of natural killer cell mediated cytotoxicity + 13
                      positive regulation of natural killer cell mediated cytotoxicity + 21
                      regulation of natural killer cell degranulation + 4
                      regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 8
paths to the root