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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of natural killer cell mediated cytotoxicity
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Accession:GO:0042269 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.
Synonyms:exact_synonym: regulation of NK cell mediated cell death;   regulation of NK cell mediated cell killing;   regulation of natural killer cell mediated cell death;   regulation of natural killer cell mediated cell killing
 related_synonym: regulation of NK cell mediated cytolysis;   regulation of NK cell mediated cytotoxicity;   regulation of natural killer cell mediated cytolysis


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regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lep leptin involved_in ISO (PMID:12504075) UniProt PMID:12504075 NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
JBrowse link
G Pik3r6 phosphoinositide-3-kinase regulatory subunit 6 involved_in ISO (PMID:11062502) CACAO PMID:11062502 NCBI chrNW_004955467:8,104,242...8,157,637
Ensembl chrNW_004955467:8,104,906...8,157,144
JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) UniProt PMID:23408620 MGI:5491117 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in ISO (PMID:18604210) UniProt PMID:18604210 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G Clec12b C-type lectin domain family 12 member B involved_in ISO (PMID:17562706) UniProt PMID:17562706 NCBI chrNW_004955413:7,842,994...7,852,685
Ensembl chrNW_004955413:7,842,931...7,852,828
JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:18835194 RGD:11568650 NCBI chrNW_004955481:1,705,595...1,748,363
Ensembl chrNW_004955481:1,705,520...1,734,859
JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:9021955 RGD:9685777 NCBI chrNW_004955442:15,280,753...15,283,405
Ensembl chrNW_004955442:15,281,419...15,283,266
JBrowse link
G Igf2 insulin like growth factor 2 ISO RGD PMID:9021955 RGD:9685777 NCBI chrNW_004955422:13,880,525...13,907,963
Ensembl chrNW_004955422:13,880,471...13,888,566
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) UniProt PMID:23408620 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Sh2d1b SH2 domain containing 1B acts_upstream_of_or_within ISO (MGI:3639618|PMID:16127454) MGI PMID:16127454 MGI:3639618 NCBI chrNW_004955462:13,909,266...13,934,239
Ensembl chrNW_004955462:13,909,258...13,931,526
JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO (PMID:23696226)
(MGI:5512785|PMID:23696226)
UniProt PMID:23696226 MGI:5512785 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320
JBrowse link
G LOC102005691 NKG2-D type II integral membrane protein ISO RGD PMID:12782717 RGD:1299590 NCBI chrNW_004955413:7,489,158...7,503,014
Ensembl chrNW_004955413:7,489,127...7,504,956
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955484:4,430,461...4,511,368
Ensembl chrNW_004955484:4,430,461...4,510,497
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chrNW_004955568:365,700...372,149 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379
JBrowse link
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955484:4,430,461...4,511,368
Ensembl chrNW_004955484:4,430,461...4,510,497
JBrowse link
G Cadm1 cell adhesion molecule 1 involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
UniProt PMID:15811952 MGI:3689781 NCBI chrNW_004955412:16,673,401...17,005,082
Ensembl chrNW_004955412:16,669,099...17,005,014
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:12486241), (PMID:17307798) UniProt PMID:12486241 PMID:17307798 NCBI chrNW_004955568:365,700...372,149 JBrowse link
G Cd226 CD226 molecule involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chrNW_004955402:53,408,861...53,560,896
Ensembl chrNW_004955402:53,473,131...53,560,924
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
HGNC-UCL
UniProt
PMID:15811952 MGI:3689781 NCBI chrNW_004955412:23,676,171...23,706,250
Ensembl chrNW_004955412:23,675,906...23,709,262
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:2204066) UniProt PMID:2204066 NCBI chrNW_004955448:10,611,131...10,617,911 JBrowse link
G Il18rap interleukin 18 receptor accessory protein acts_upstream_of_or_within ISO (MGI:3578455|PMID:15843532) MGI PMID:15843532 MGI:3578455 NCBI chrNW_004955470:7,894,900...7,923,653
Ensembl chrNW_004955470:7,893,329...7,923,744
JBrowse link
G Il21 interleukin 21 involved_in
acts_upstream_of_or_within
ISO (PMID:18005035)
(MGI:3028812|PMID:14764669)
CACAO
MGI
PMID:14764669 PMID:18005035 MGI:3028812 NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492
JBrowse link
G Lag3 lymphocyte activating 3 acts_upstream_of_or_within ISO (MGI:80003|PMID:8602528) MGI PMID:8602528 MGI:80003 NCBI chrNW_004955413:4,379,529...4,385,456
Ensembl chrNW_004955413:4,378,972...4,385,909
JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379
JBrowse link
G LOC102005691 NKG2-D type II integral membrane protein involved_in ISO (PMID:15294961) UniProt PMID:15294961 NCBI chrNW_004955413:7,489,158...7,503,014
Ensembl chrNW_004955413:7,489,127...7,504,956
JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chrNW_004955437:130,360...134,751 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link
G Raet1e retinoic acid early transcript 1E involved_in ISO (PMID:18544572) UniProt PMID:18544572 NCBI chrNW_004955439:11,413,978...11,420,902 JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (PMID:19933860) UniProt PMID:19933860 NCBI chrNW_004955416:5,494,030...5,561,608
Ensembl chrNW_004955416:5,494,030...5,561,614
JBrowse link
G Sh2d1a SH2 domain containing 1A acts_upstream_of_or_within ISO (MGI:3639618|PMID:16127454)
(MGI:4355255|PMID:19648922)
MGI PMID:16127454 PMID:19648922 MGI:3639618 MGI:4355255 NCBI chrNW_004955473:10,345,407...10,370,535
Ensembl chrNW_004955473:10,346,943...10,370,575
JBrowse link
G Sh2d1b SH2 domain containing 1B acts_upstream_of_or_within ISO (MGI:4355255|PMID:19648922)
(MGI:4839659|PMID:20962259)
MGI PMID:19648922 PMID:20962259 MGI:4355255 MGI:4839659 NCBI chrNW_004955462:13,909,266...13,934,239
Ensembl chrNW_004955462:13,909,258...13,931,526
JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:16920955) UniProt PMID:16920955 NCBI chrNW_004955468:12,233,629...12,264,502 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (MGI:3655409|PMID:9841920) MGI PMID:9841920 MGI:3655409 NCBI chrNW_004955451:16,305,363...16,319,219 JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO (MGI:3655409|PMID:9841920) MGI PMID:9841920 MGI:3655409 NCBI chrNW_004955451:16,253,645...16,295,337 JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (MGI:4839659|PMID:20962259) MGI PMID:20962259 MGI:4839659 NCBI chrNW_004955495:2,697,508...2,755,468
Ensembl chrNW_004955495:2,695,730...2,755,824
JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd226 CD226 molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chrNW_004955402:53,408,861...53,560,896
Ensembl chrNW_004955402:53,473,131...53,560,924
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
HGNC-UCL
UniProt
PMID:15811952 MGI:3689781 NCBI chrNW_004955412:23,676,171...23,706,250
Ensembl chrNW_004955412:23,675,906...23,709,262
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:7903063) UniProt PMID:7903063 NCBI chrNW_004955448:10,611,131...10,617,911 JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:7903063) UniProt PMID:7903063 NCBI chrNW_004955408:13,302,506...13,316,300
Ensembl chrNW_004955408:13,304,219...13,312,620
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tap1 transporter 1, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chrNW_004955437:1,504,549...1,511,110
Ensembl chrNW_004955437:1,504,947...1,511,097
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:8120379 RGD:2312378 NCBI chrNW_004955437:1,480,217...1,499,032
Ensembl chrNW_004955437:1,477,341...1,498,575
JBrowse link
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm1 cell adhesion molecule 1 involved_in ISO (PMID:15811952)
(MGI:3689781|PMID:15811952)
UniProt PMID:15811952 MGI:3689781 NCBI chrNW_004955412:16,673,401...17,005,082
Ensembl chrNW_004955412:16,669,099...17,005,014
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chrNW_004955555:1,959,702...1,985,679 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12272
    regulation of biological process 8566
      regulation of cellular process 8067
        regulation of cell killing 83
          regulation of leukocyte mediated cytotoxicity 62
            regulation of natural killer cell mediated cytotoxicity 34
              negative regulation of natural killer cell mediated cytotoxicity + 12
              positive regulation of natural killer cell mediated cytotoxicity + 22
              regulation of natural killer cell degranulation + 4
              regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 8
Path 2
Term Annotations click to browse term
  biological_process 12272
    response to stimulus 6645
      response to biotic stimulus 1206
        response to external biotic stimulus 1164
          response to other organism 1161
            defense response to other organism 739
              innate immune response 499
                natural killer cell mediated immunity 54
                  regulation of natural killer cell mediated immunity 37
                    regulation of natural killer cell mediated cytotoxicity 34
                      negative regulation of natural killer cell mediated cytotoxicity + 12
                      positive regulation of natural killer cell mediated cytotoxicity + 22
                      regulation of natural killer cell degranulation + 4
                      regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 8
paths to the root