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ONTOLOGY REPORT - ANNOTATIONS

Term:heme metabolic process
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Accession:GO:0042168 term browser browse the term
Definition:The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
Synonyms:exact_synonym: haem metabolic process;   haem metabolism;   heme metabolism

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heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 (LAN blood group) involved_in ISO (PMID:33007128) UniProt PMID:33007128 NCBI chrNW_004955453:14,215,104...14,222,338
Ensembl chrNW_004955453:14,215,408...14,222,172 		JBrowse link
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO (PMID:16183037) MGI PMID:16183037 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
G Hpx hemopexin acts_upstream_of_or_within ISO (PMID:18556779) MGI PMID:18556779 NCBI chrNW_004955414:22,158,654...22,169,133
Ensembl chrNW_004955414:22,156,819...22,169,631 		JBrowse link
G Slc48a1 solute carrier family 48 member 1 involved_in ISO (PMID:31571584) MGI PMID:31571584 NCBI chrNW_004955500:6,675,631...6,691,942
Ensembl chrNW_004955500:6,679,908...6,691,942 		JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within ISO (PMID:11134514) MGI PMID:11134514 NCBI chrNW_004955464:13,226,271...13,228,908
Ensembl chrNW_004955464:13,221,551...13,229,253 		JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in ISO (PMID:5393940)
(PMID:14050799)		 MGI PMID:5393940 PMID:14050799 NCBI chrNW_004955419:14,093,010...14,104,376
Ensembl chrNW_004955419:14,093,010...14,104,545 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in ISO (PMID:33307066) MGI PMID:33307066 NCBI chrNW_004955532:3,810,469...3,823,456
Ensembl chrNW_004955532:3,810,464...3,823,456 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in ISO (PMID:8407975) MGI PMID:8407975 NCBI chrNW_004955427:152,397...163,570
Ensembl chrNW_004955427:152,894...164,030 		JBrowse link
G Fech ferrochelatase involved_in ISO (PMID:15677551) MGI PMID:15677551 NCBI chrNW_004955402:41,902,868...41,938,099
Ensembl chrNW_004955402:41,902,868...41,938,174 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in ISO (PMID:8563760) MGI PMID:8563760 NCBI chrNW_004955412:20,192,519...20,202,635
Ensembl chrNW_004955412:20,192,522...20,202,635 		JBrowse link
G LOC102017801 cytochrome c oxidase assembly protein COX15 homolog involved_in ISO (PMID:12474143) HGNC-UCL PMID:12474143 NCBI chrNW_004955507:5,600,605...5,617,556
Ensembl chrNW_004955507:5,600,605...5,617,556 		JBrowse link
G LOC102022268 protoheme IX farnesyltransferase, mitochondrial involved_in
acts_upstream_of_or_within		 ISO (PMID:12928484)
(PMID:16782876)
(PMID:16103131)		 HGNC-UCL
MGI		 PMID:12928484 PMID:16103131 PMID:16782876 NCBI chrNW_004955467:3,294,200...3,415,778
Ensembl chrNW_004955467:3,292,018...3,415,778 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO (PMID:3346226) MGI PMID:3346226 NCBI chrNW_004955468:12,930,387...12,934,437
Ensembl chrNW_004955468:12,930,495...12,934,437 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in ISO (PMID:17360334) MGI PMID:17360334 NCBI chrNW_004955464:13,226,271...13,228,908
Ensembl chrNW_004955464:13,221,551...13,229,253 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO (PMID:16532394) MGI PMID:16532394 NCBI chrNW_004955477:3,673,583...3,707,761
Ensembl chrNW_004955477:3,673,532...3,707,760 		JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 (LAN blood group) NOT|involved_in ISO (PMID:22655043) UniProt PMID:22655043 NCBI chrNW_004955453:14,215,104...14,222,338
Ensembl chrNW_004955453:14,215,408...14,222,172 		JBrowse link
G Alad aminolevulinate dehydratase involved_in ISO (PMID:14050799)
(PMID:5393940)		 MGI PMID:5393940 PMID:14050799 NCBI chrNW_004955419:14,093,010...14,104,376
Ensembl chrNW_004955419:14,093,010...14,104,545 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in ISO (PMID:33307066) MGI PMID:33307066 NCBI chrNW_004955532:3,810,469...3,823,456
Ensembl chrNW_004955532:3,810,464...3,823,456 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in ISO (PMID:8407975) MGI PMID:8407975 NCBI chrNW_004955427:152,397...163,570
Ensembl chrNW_004955427:152,894...164,030 		JBrowse link
G Fech ferrochelatase involved_in ISO (PMID:15677551) MGI PMID:15677551 NCBI chrNW_004955402:41,902,868...41,938,099
Ensembl chrNW_004955402:41,902,868...41,938,174 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in ISO (PMID:8563760) MGI PMID:8563760 NCBI chrNW_004955412:20,192,519...20,202,635
Ensembl chrNW_004955412:20,192,522...20,202,635 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO (PMID:3346226) MGI PMID:3346226 NCBI chrNW_004955468:12,930,387...12,934,437
Ensembl chrNW_004955468:12,930,495...12,934,437 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in ISO (PMID:17360334) MGI PMID:17360334 NCBI chrNW_004955464:13,226,271...13,228,908
Ensembl chrNW_004955464:13,221,551...13,229,253 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO (PMID:16532394) MGI PMID:16532394 NCBI chrNW_004955477:3,673,583...3,707,761
Ensembl chrNW_004955477:3,673,532...3,707,760 		JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (MGI:5648801|PMID:24421385) UniProt PMID:24421385 MGI:5648801 NCBI chrNW_004955492:8,532,240...8,573,211
Ensembl chrNW_004955492:8,532,240...8,577,041 		JBrowse link
G Alad aminolevulinate dehydratase acts_upstream_of_or_within
involved_in		 ISO (PMID:14050799), (PMID:4959158), (PMID:4981581)
(PMID:11032836)		 RGD
MGI
UniProt		 PMID:1764448 PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799 RGD:1599020 NCBI chrNW_004955419:14,093,010...14,104,376
Ensembl chrNW_004955419:14,093,010...14,104,545 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISO (MGI:3694153|PMID:9446639) UniProt PMID:9446639 MGI:3694153 NCBI chrNW_004955475:2,362,368...2,382,680
Ensembl chrNW_004955475:2,362,118...2,377,864 		JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:23135403)
(MGI:5447588|PMID:23135403)		 UniProt PMID:23135403 MGI:5447588 NCBI chrNW_004955452:7,372,917...7,375,072
Ensembl chrNW_004955452:7,373,001...7,375,856 		JBrowse link
G Cpox coproporphyrinogen oxidase acts_upstream_of_or_within ISO (PMID:8407975) RGD
MGI		 PMID:3955059 PMID:8407975 RGD:1600961 NCBI chrNW_004955427:152,397...163,570
Ensembl chrNW_004955427:152,894...164,030 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within
involved_in		 ISO (PMID:8611576)
(PMID:15496139), (PMID:16503645)
(PMID:16306232)
(PMID:9989256)
(PMID:27599036)		 RGD
MGI
UniProt		 PMID:3955059 PMID:8611576 PMID:9989256 PMID:15496139 PMID:16306232 More... RGD:1600961 NCBI chrNW_004955402:41,902,868...41,938,099
Ensembl chrNW_004955402:41,902,868...41,938,174 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in ISO (PMID:18936296) UniProt PMID:18936296 NCBI chrNW_004955412:20,192,519...20,202,635
Ensembl chrNW_004955412:20,192,522...20,202,635 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO (PMID:10617683) MGI PMID:10617683 NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 involved_in ISO (PMID:27599036) UniProt PMID:27599036 NCBI chrNW_004955534:698,895...706,586
Ensembl chrNW_004955534:698,734...706,946 		JBrowse link
G Ppox protoporphyrinogen oxidase acts_upstream_of_or_within
involved_in		 ISO (PMID:3346226)
(PMID:7713909)		 RGD
MGI
UniProt		 PMID:3346226 PMID:3955059 PMID:7713909 RGD:1600961 NCBI chrNW_004955468:12,930,387...12,934,437
Ensembl chrNW_004955468:12,930,495...12,934,437 		JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within ISO (PMID:17360334) MGI PMID:17360334 NCBI chrNW_004955464:13,226,271...13,228,908
Ensembl chrNW_004955464:13,221,551...13,229,253 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO (PMID:3805019) UniProt PMID:3805019 NCBI chrNW_004955477:3,673,583...3,707,761
Ensembl chrNW_004955477:3,673,532...3,707,760 		JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blvra biliverdin reductase A involved_in ISO (PMID:10858451) UniProt PMID:10858451 NCBI chrNW_004955460:129,077...167,345
Ensembl chrNW_004955460:125,854...167,506 		JBrowse link
G Blvrb biliverdin reductase B involved_in ISO (PMID:10858451), (PMID:7929092) UniProt PMID:7929092 PMID:10858451 NCBI chrNW_004955578:813,834...834,675
Ensembl chrNW_004955578:813,480...838,151 		JBrowse link
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:31571584)
(PMID:17915953)		 RGD
MGI
BHF-UCL		 PMID:15226268 PMID:17915953 PMID:31571584 RGD:1547877 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in ISO (PMID:5393940)
(PMID:14050799)		 MGI PMID:5393940 PMID:14050799 NCBI chrNW_004955419:14,093,010...14,104,376
Ensembl chrNW_004955419:14,093,010...14,104,545 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in ISO (PMID:33307066) MGI PMID:33307066 NCBI chrNW_004955532:3,810,469...3,823,456
Ensembl chrNW_004955532:3,810,464...3,823,456 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in ISO (PMID:8407975) MGI PMID:8407975 NCBI chrNW_004955427:152,397...163,570
Ensembl chrNW_004955427:152,894...164,030 		JBrowse link
G Fech ferrochelatase involved_in ISO (PMID:15677551) MGI PMID:15677551 NCBI chrNW_004955402:41,902,868...41,938,099
Ensembl chrNW_004955402:41,902,868...41,938,174 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in ISO (PMID:8563760) MGI PMID:8563760 NCBI chrNW_004955412:20,192,519...20,202,635
Ensembl chrNW_004955412:20,192,522...20,202,635 		JBrowse link
G LOC102022268 protoheme IX farnesyltransferase, mitochondrial involved_in ISO (PMID:12928484) MGI PMID:12928484 NCBI chrNW_004955467:3,294,200...3,415,778
Ensembl chrNW_004955467:3,292,018...3,415,778 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO (PMID:3346226) MGI PMID:3346226 NCBI chrNW_004955468:12,930,387...12,934,437
Ensembl chrNW_004955468:12,930,495...12,934,437 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in ISO (PMID:17360334) MGI PMID:17360334 NCBI chrNW_004955464:13,226,271...13,228,908
Ensembl chrNW_004955464:13,221,551...13,229,253 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO (PMID:16532394) MGI PMID:16532394 NCBI chrNW_004955477:3,673,583...3,707,761
Ensembl chrNW_004955477:3,673,532...3,707,760 		JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 involved_in ISO (PMID:17915953) BHF-UCL PMID:17915953 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISO (PMID:30765471)
(MGI:6695684|PMID:30765471)		 UniProt PMID:30765471 MGI:6695684 NCBI chrNW_004955562:1,079,884...1,220,806
Ensembl chrNW_004955562:1,077,198...1,221,061 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO (MGI:6450351|PMID:28495915) ARUK-UCL PMID:28495915 MGI:6450351 NCBI chrNW_004955537:3,520,516...3,549,492
Ensembl chrNW_004955537:3,520,516...3,550,022 		JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase ISO RGD PMID:3814086 RGD:4145128 NCBI chrNW_004955427:152,397...163,570
Ensembl chrNW_004955427:152,894...164,030 		JBrowse link
G Ireb2 iron responsive element binding protein 2 acts_upstream_of_or_within ISO (PMID:15831703) MGI PMID:15831703 NCBI chrNW_004955450:852,554...898,908
Ensembl chrNW_004955450:852,554...900,011 		JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing involved_in ISO (MGI:6282940|PMID:28802827) UniProt PMID:28802827 MGI:6282940 NCBI chrNW_004955455:1,076,113...1,090,346
Ensembl chrNW_004955455:1,075,652...1,083,102 		JBrowse link
G Tmem14c transmembrane protein 14C acts_upstream_of_or_within ISO (PMID:25157825) MGI PMID:25157825 NCBI chrNW_004955465:3,621,652...3,628,355
Ensembl chrNW_004955465:3,621,652...3,628,355 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      pigment metabolic process 56
        heme metabolic process 26
          heme B metabolic process + 9
          heme C metabolic process + 0
          heme O metabolic process + 9
          heme a metabolic process + 10
          heme biosynthetic process + 21
          heme catabolic process + 3
          heme oxidation 1
          siroheme metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      organic substance metabolic process 7146
        organic cyclic compound metabolic process 4092
          tetrapyrrole metabolic process 42
            porphyrin-containing compound metabolic process 32
              heme metabolic process 26
                heme B metabolic process + 9
                heme C metabolic process + 0
                heme O metabolic process + 9
                heme a metabolic process + 10
                heme biosynthetic process + 21
                heme catabolic process + 3
                heme oxidation 1
                siroheme metabolic process + 0
paths to the root