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ONTOLOGY REPORT - ANNOTATIONS

Term:meiotic DNA double-strand break formation
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Accession:GO:0042138 term browser browse the term
Definition:The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.

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meiotic DNA double-strand break formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC119332.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:219,864,113...219,898,243 JBrowse link
G Hormad1 HORMA domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4868505|PMID:21079677), (MGI:5009722|PMID:21478856)		 UniProt
RGD		 PMID:21079677 PMID:21478856 GO_REF:0000024 MGI:4868505 MGI:5009722 NCBI chr 2:197,681,820...197,720,197
Ensembl chr 2:197,682,000...197,719,254 		JBrowse link
G Iho1 interactor of HORMAD1 1 involved_in IBA
ISO		 PMID:21873635
(MGI:5822944|PMID:27723721)		 RGD PMID:27723721, PMID:21873635 MGI:5822944, RGD:13792537 NCBI chr 8:117,182,484...117,215,390
Ensembl chr 8:117,183,343...117,211,170 		JBrowse link
G Mei4 meiotic double-stranded break formation protein 4 involved_in IBA
ISO		 PMID:21873635
(MGI:4457793|PMID:20551173)		 RGD PMID:20551173, PMID:21873635 MGI:4457793, RGD:13792537 NCBI chr 8:89,369,417...89,556,942
Ensembl chr 8:89,369,417...89,556,942 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G RGD1563323 similar to hypothetical protein FLJ22531 involved_in ISO (MGI:5752405|PMID:26917764) RGD PMID:26917764 MGI:5752405 NCBI chr 1:219,864,108...219,952,143 JBrowse link
G Spo11 SPO11, initiator of meiotic double stranded breaks involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:170,991,573...171,008,226
Ensembl chr 3:170,994,038...171,013,185 		JBrowse link
meiotic DNA double-strand break formation involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd31 ankyrin repeat domain 31 involved_in ISO (MGI:6316415|PMID:31003867), (MGI:6316551|PMID:31000436) RGD PMID:31000436 PMID:31003867 MGI:6316415 MGI:6316551 NCBI chr 2:27,571,129...27,743,668 JBrowse link
positive regulation of meiotic DNA double-strand break formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd31 ankyrin repeat domain 31 involved_in ISO (MGI:6316415|PMID:31003867), (MGI:6316551|PMID:31000436) RGD PMID:31000436 PMID:31003867 MGI:6316415 MGI:6316551 NCBI chr 2:27,571,129...27,743,668 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    reproductive process 1800
      meiotic cell cycle process 229
        meiosis I cell cycle process 138
          meiotic DNA double-strand break formation 8
            meiotic DNA double-strand break formation involved in meiotic gene conversion 0
            meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
            negative regulation of meiotic DNA double-strand break formation + 0
            positive regulation of meiotic DNA double-strand break formation + 1
            regulation of meiotic DNA double-strand break formation + 1
Path 2
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      cellular metabolic process 10838
        cellular aromatic compound metabolic process 5627
          nucleobase-containing compound metabolic process 5410
            nucleic acid metabolic process 4921
              nucleic acid phosphodiester bond hydrolysis 266
                meiotic DNA double-strand break formation 8
                  meiotic DNA double-strand break formation involved in meiotic gene conversion 0
                  meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
                  negative regulation of meiotic DNA double-strand break formation + 0
                  positive regulation of meiotic DNA double-strand break formation + 1
                  regulation of meiotic DNA double-strand break formation + 1
paths to the root