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ONTOLOGY REPORT - ANNOTATIONS

Term:meiotic DNA double-strand break formation
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Accession:GO:0042138 term browser browse the term
Definition:The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


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meiotic DNA double-strand break formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hormad1 HORMA domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4868505|PMID:21079677), (MGI:5009722|PMID:21478856)		 UniProt
RGD		 PMID:21079677 PMID:21478856 GO_REF:0000024 MGI:4868505 MGI:5009722 NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383 		JBrowse link
G Iho1 interactor of HORMAD1 1 involved_in ISO
IBA		 (MGI:5822944|PMID:27723721)
GO_REF:0000033
(PMID:27723721)		 RGD
GO_Central		 PMID:27723721 GO_REF:0000033 MGI:5822944 NCBI chr 8:109,091,134...109,126,386
Ensembl chr 8:109,092,758...109,125,434 		JBrowse link
G Mei4 meiotic double-stranded break formation protein 4 involved_in ISO
IBA		 (MGI:4457793|PMID:20551173)
GO_REF:0000033		 RGD
GO_Central		 PMID:20551173 GO_REF:0000033 MGI:4457793 NCBI chr 8:82,765,661...82,939,649
Ensembl chr 8:82,765,661...82,939,649 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Rec114 REC114 meiotic recombination protein involved_in ISO (MGI:6279435|PMID:30569039)
(PMID:30569039)		 RGD PMID:30569039 MGI:6279435 NCBI chr 8:59,063,352...59,221,439
Ensembl chr 8:59,063,352...59,149,887 		JBrowse link
G Spo11 SPO11 initiator of meiotic double strand breaks involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:161,755,299...161,770,930
Ensembl chr 3:161,757,519...161,770,925 		JBrowse link
G Top6bl TOP6B like initiator of meiotic double strand breaks involved_in ISO
IBA		 (MGI:5752405|PMID:26917764)
GO_REF:0000033		 RGD
GO_Central		 PMID:26917764 GO_REF:0000033 MGI:5752405 NCBI chr 1:201,902,564...201,989,945 JBrowse link
meiotic DNA double-strand break formation involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd31 ankyrin repeat domain 31 involved_in ISO (MGI:6316415|PMID:31003867), (MGI:6316551|PMID:31000436)
(PMID:31000436), (PMID:31003867)		 RGD PMID:31000436 PMID:31003867 MGI:6316415 MGI:6316551 NCBI chr 2:28,079,187...28,241,722
Ensembl chr 2:28,092,882...28,241,719 		JBrowse link
positive regulation of meiotic DNA double-strand break formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd31 ankyrin repeat domain 31 involved_in ISO (MGI:6316415|PMID:31003867), (MGI:6316551|PMID:31000436)
(PMID:31000436), (PMID:31003867)		 RGD PMID:31000436 PMID:31003867 MGI:6316415 MGI:6316551 NCBI chr 2:28,079,187...28,241,722
Ensembl chr 2:28,092,882...28,241,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20133
    reproductive process 1939
      meiotic cell cycle process 250
        meiosis I cell cycle process 147
          meiotic DNA double-strand break formation 8
            meiotic DNA double-strand break formation involved in meiotic gene conversion 0
            meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
            negative regulation of meiotic DNA double-strand break formation + 0
            positive regulation of meiotic DNA double-strand break formation + 1
            regulation of meiotic DNA double-strand break formation + 1
Path 2
Term Annotations click to browse term
  biological_process 20133
    cellular process 19325
      metabolic process 12307
        primary metabolic process 10934
          nucleobase-containing compound metabolic process 5743
            nucleic acid metabolic process 5151
              DNA metabolic process 961
                meiotic DNA double-strand break formation 8
                  meiotic DNA double-strand break formation involved in meiotic gene conversion 0
                  meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + 1
                  negative regulation of meiotic DNA double-strand break formation + 0
                  positive regulation of meiotic DNA double-strand break formation + 1
                  regulation of meiotic DNA double-strand break formation + 1
paths to the root