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ONTOLOGY REPORT - ANNOTATIONS


Term:neutrophil activation
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Accession:GO:0042119 term browser browse the term
Definition:The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.



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neutrophil activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO
ISS
(PMID:22879591)
GO_REF:0000024
RGD
UniProt
PMID:22879591 GO_REF:0000024 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Camp cathelicidin antimicrobial peptide involved_in ISO (PMID:22879591) RGD PMID:22879591 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 involved_in ISO (PMID:10488085) RGD PMID:10488085 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctsg cathepsin G involved_in ISO (PMID:22879591) RGD PMID:22879591 NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 involved_in IEA
ISO
GO_REF:0000107
(PMID:8399143)
Ensembl
RGD
PMID:8399143 GO_REF:0000107 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 involved_in ISO (PMID:10878382) RGD PMID:10878382 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS
(PMID:15155775)
GO_REF:0000024
RGD
UniProt
PMID:15155775 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fcar Fc alpha receptor involved_in ISO (PMID:25339672) RGD PMID:25339672 NCBI chr 1:69,626,458...69,660,558 JBrowse link
G Fcgr3a Fc gamma receptor IIIa involved_in ISO (MGI:3772527|PMID:18097064) RGD PMID:18097064 MGI:3772527 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Il15 interleukin 15 involved_in ISO
IBA
ISS
(PMID:15123770)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:15123770 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3578455|PMID:15843532)
Ensembl
RGD
PMID:15843532 GO_REF:0000107 MGI:3578455 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18rap interleukin 18 receptor accessory protein acts_upstream_of_or_within ISO MGI:3579137 (MGI:3578455|PMID:15843532) RGD PMID:15843532 MGI:3578455 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
JBrowse link
G Kmt2e lysine methyltransferase 2E involved_in ISO (MGI:3834766|PMID:18854576) RGD PMID:18854576 MGI:3834766 NCBI chr 4:11,657,811...11,727,373
Ensembl chr 4:11,658,979...11,727,373
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA
(PMID:10770950)
GO_REF:0000107
RGD
Ensembl
PMID:10770950 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (MGI:3830743|PMID:19155512) RGD PMID:19155512 MGI:3830743 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
JBrowse link
negative regulation of neutrophil activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:17588661) RGD PMID:17588661 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Grn granulin precursor involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12526812)
Ensembl
UniProt
RGD
PMID:12526812 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
negative regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:88141 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:107771 (MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:4366690 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6381024|PMID:30911105) RGD PMID:30911105 MGI:6381024 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
neutrophil activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase1 deoxyribonuclease 1 involved_in ISS
ISO
PMID:29191910
(MGI:6094744|PMID:29191910)
RGD PMID:29191910 PMID:29191910 MGI:6094744, RGD:13464261 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 involved_in ISS
ISO
PMID:29191910
(MGI:6094744|PMID:29191910)
RGD PMID:29191910 PMID:29191910 MGI:6094744, RGD:13464261 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317
JBrowse link
G Fcer1g Fc epsilon receptor Ig involved_in IBA
ISO
PMID:21873635
(MGI:3693026|PMID:17086186)
RGD PMID:17086186 PMID:21873635 MGI:3693026, RGD:13792537 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:104696 (MGI:6478086|PMID:22419116) RGD PMID:22419116 MGI:6478086 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108005 (MGI:6478086|PMID:22419116)
Ensembl
RGD
PMID:22419116 GO_REF:0000107 MGI:6478086 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:3693026|PMID:17086186)
GO_REF:0000024
PMID:21873635
Ensembl
RGD
UniProt
PMID:17086186 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3693026, RGD:13792537 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in IBA
ISO
PMID:21873635
(MGI:3693026|PMID:17086186)
RGD PMID:17086186 PMID:21873635 MGI:3693026, RGD:13792537 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa3 annexin A3 involved_in ISO (PMID:9550422) RGD PMID:9550422 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Myo1f myosin IF acts_upstream_of_or_within ISO MGI:3664779 (MGI:3664353|PMID:17023661) RGD PMID:17023661 MGI:3664353 NCBI chr 7:14,363,340...14,413,911
Ensembl chr 7:14,363,350...14,413,911
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing NOT|involved_in ISO (MGI:6103777|PMID:28779020) RGD PMID:28779020 MGI:6103777 NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868
JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (MGI:5460953|PMID:23042080) RGD PMID:23042080 MGI:5460953 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164
JBrowse link
G Stxbp2 syntaxin binding protein 2 involved_in ISO
IEA
(PMID:18588921)
GO_REF:0000107
RGD
Ensembl
PMID:18588921 GO_REF:0000107 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in ISO (PMID:18588921) RGD PMID:18588921 NCBI chr 2:196,442,738...196,485,733
Ensembl chr 2:196,442,634...196,485,671
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in IDA
ISO
PMID:14993220
(PMID:16677249)
RGD PMID:16677249 PMID:14993220 RGD:8553828 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 NOT|involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
positive regulation of neutrophil activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il16 interleukin 16 acts_upstream_of_or_within ISO (MGI:6414686|PMID:30089723) RGD PMID:30089723 MGI:6414686 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Plpp6 phospholipid phosphatase 6 involved_in ISO
ISS
(PMID:23568778)
GO_REF:0000024
RGD
UniProt
PMID:23568778 GO_REF:0000024 NCBI chr 1:226,679,100...226,681,952
Ensembl chr 1:226,679,100...226,681,949
JBrowse link
G Tnf tumor necrosis factor IMP rat protein with human cells RGD PMID:8283134 RGD:14995443 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in IBA
ISO
PMID:21873635
UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407)
RGD PMID:21193407 PMID:21873635 RGD:13792537 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G LOC681077 similar to testis expressed gene 101 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:80,308,234...80,312,967
Ensembl chr 1:80,308,643...80,312,222
JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:2829894 RGD:10041060 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G RGD1564380 similar to BC049730 protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:80,273,019...80,278,238
Ensembl chr 1:80,273,019...80,278,219
JBrowse link
G RGD1565655 similar to BC049730 protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:80,323,188...80,328,311
Ensembl chr 1:80,323,863...80,328,311
JBrowse link
regulation of neutrophil activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g2a phospholipase A2 group IIA involved_in ISS
ISO
GO_REF:0000024
(PMID:25082876)
UniProt
RGD
PMID:25082876 GO_REF:0000024 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pram1 PML-RARA regulated adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3579812 (MGI:3525750|PMID:15572693) RGD PMID:15572693 MGI:3525750 NCBI chr 7:14,428,548...14,438,081 JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4414596|PMID:19797524)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19797524 GO_REF:0000024 GO_REF:0000107 MGI:4414596 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    immune system process 2829
      leukocyte activation 1079
        myeloid leukocyte activation 267
          granulocyte activation 55
            neutrophil activation 49
              negative regulation of neutrophil activation + 5
              neutrophil activation involved in immune response + 27
              positive regulation of neutrophil activation + 10
              regulation of neutrophil activation + 18
Path 2
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cell activation 1223
        leukocyte activation 1079
          myeloid leukocyte activation 267
            granulocyte activation 55
              neutrophil activation 49
                negative regulation of neutrophil activation + 5
                neutrophil activation involved in immune response + 27
                positive regulation of neutrophil activation + 10
                regulation of neutrophil activation + 18
paths to the root